antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-100Research ArticleОБЗОРЫREVIEWSЭкзополисахариды морских бактерий: перспективы применения в медицинеExopolysaccharides of Marine Bacteria: Prospects for Use in MedicineБеседноваН. Н.BesednovaN. N.noemail@neicon.ruСмолинаТ. П.SmolinaT. P.noemail@neicon.ruАндрюковБ. Г.AndryukovB. G.noemail@neicon.ruКузнецоваТ. А.KuznetsovaT. A.noemail@neicon.ruМихайловВ. В.MikhailovV. V.noemail@neicon.ruЗвягинцеваТ. Н.ZvyagintsevaT. N.noemail@neicon.ruНаучно-исследовательский институт эпидемиологии и микробиологии им. Г. П. СомоваРоссияSomov Institute of Epidemiology and MicrobiologyRussian FederationТихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАНРоссияG. B. Elyakov Pacific Institute of Bioorganic ChemistryRussian Federation201806052020637-86778Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/100

В обзоре представлены основные направления биомедицинских исследований, посвящённых экзополисахаридам (ЭПС), полученным из различных видов морских бактерий. ЭПС - высокомолекулярные полимеры, состоящие из остатков сахаров и отличающиеся большим разнообразием структуры, что обусловливает их уникальные биологические свойства. Приведены многочисленные данные, касающиеся антиоксидантной, иммуномодулирующей и противоопухолевой активности ЭПС. Особое внимание обращается на противовирусное, антибактериальное и ингибирующее действие ЭПС на формирование биоплёнок. С учётом широкого спектра фармакологической активности и низкой токсичности эти соединения привлекают к себе внимание в качестве потенциального источника лекарственных субстанций.

The review presents the main directions of biomedical research on exopolysaccharides (EPS) obtained from various species of marine bacteria. EPS are high molecular weight polymers consisting of sugar residues; they are characterized by a large variety of structures, which causes unique biological properties. Numerous data on antioxidant, immunomodulatory, and antitumor activity of EPS are presented. Particular attention is drawn to the antiviral, antibacterial, and inhibitory effect of EPS on the formation of biofilms. Taking into account the wide spectrum of pharmacological activity and low toxicity, these compounds have attracted attention as a potential source of medicinal substances.

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The authors declare that there are no conflicts of interest present.