antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2023-68-5-6-33-38antibiotics-1047Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИExperimental ResearchИзучение токсического проявления этопозида при сопутствующем воздействии ацетилсалициловой кислотой в качестве протектора на примере мышей линии C57Bl/6JStudy of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Linehttps://orcid.org/0000-0003-3902-298XАнтосюкО. Н.AntosyukO. N.

к. б. н., доцент

ул. Мира, д. 19, Уральский федеральный университет им. первго Президента России Б. Н. Ельцина, г. Екатеринбург,  620002

Ph. D. in Biology, Associate Professor

19 Mira st,, Ural Federal University named after the first President of Russia B. N.Yeltsin, Yekaterinburg, 620002 

antosuk-olga@mail.ruГорскаяГ. А.GorskayaA. V.

студентка

student

https://orcid.org/0000-0002-0623-0363ПетровскийД. В.PetrovskiiD. V.

к.б.н., главный эксперт, Институт систематики и экологии СО РАН; ФИИ Институт цитологии и генетики СО РАН

Ph. D. in Biology, chief expert  Institute of Systematics and Ecology of Animals of the Siberian Branch of the Russian Academy of Sciences

ДубатоловаТ. Д.DubatolovaT. D.

научный сотрудник, ФИИ Институт цитологии и генетики СО РАН

Researcher

ФГАОУ ВО «Уральский федеральный университет им. первого Президента России Б. Н. Ельцина»РоссияUral Federal University named after the first President of Russia B. N. YeltsinRussian FederationФГБУН «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН); ФГБУН Институт систематики и экологии животных Сибирского отделения Российской академии наук (ИСиЭЖ СО РАН)РоссияFederal Research Center «Institute of Cytology and Genetics» of the Siberian Branch of the Russian Academy of Sciences; Institute of Systematics and Ecology of Animals of the Siberian Branch of the Russian Academy of SciencesRussian FederationФГБУН Институт молекулярной и клеточной биологии Сибирского отделения Российской академии наук (ИМКБ СО РАН)РоссияInstitute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of SciencesRussian Federation202323102023685-63338Copyright © Антосюк О.Н., Горская Г.А., Петровский Д.В., Дубатолова Т.Д., 20232023Антосюк О.Н., Горская Г.А., Петровский Д.В., Дубатолова Т.Д.Antosyuk O.N., Gorskaya A.V., Petrovskii D.V., Dubatolova T.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1047

В работе приводятся результаты оценки генетической и цитогенетической токсичности этопозида и результаты оценки способности аспирина проявлять протекторные свойства против токсичности этопозида на мышах линии C57Bl/6J. Оценка цитогенетической активности и протекторности проводилась с использованием анализа хромосомных аберраций в метафазных пластинках. Тестировали этопозид в концентрации 15 и 3 мг/кг и аспирин в концентрации 25 мг/кг массы животного. Результаты метафазного анализа показали, что этопозид в обеих концентрациях обладает цитогенетической токсичностью, а аспирин проявляет протекторные свойства против токсичности этопозида в концентрации 15 мг/кг. Результаты хромосомного анализа в отношении протекторности аспирина против этопозида в концентрации 3 мг/кг неоднозначны и требуют дальнейших экспериментов.

The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out using the chromosome aberration analysis in metaphase cells. Etoposide was tested at a concentration of 15 and 3 mg/kg and aspirin — at a concentration of 25 mg/kg of the animal. The results of metaphase analysis showed that etoposide exhibits cytogenetic toxicity in both doses, and aspirin exhibits protective properties against the toxicity of etoposide at a concentration of 15 mg/kg. The results of chromosome analysis regarding the protective properties of aspirin against etoposide at a concentration of 3 mg/kg are ambiguous and require further experiments.

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The authors declare that there are no conflicts of interest present.