antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2023-68-7-8-78-82antibiotics-1066Research ArticleОБЗОРЫREVIEWSИзменение этиологической структуры и особенности выбора антибактериальной терапии при инфекционном эндокардите в педиатрической практикеChanges in the Etiological Structure and Specifics When Choosing Antibacterial Therapy Against Infective Endocarditis in Pediatric PracticeДаниловА. И.DanilovА. I.

Данилов Андрей Игоревич — к. м. н., доцент кафедры клинической фармакологии

ул. Крупской, 28, Смоленск, 214019

Andrey I. Danilov — Ph. D. in Medicine, Associate Professor of the Department of Clinical Pharmacology

28 Krupskoy st., Smolensk, 214019 

dr.danandr@yandex.ruЕвсеевА. В.EvseevА. V.

Евсеев Андрей Викторович — д. м. н., профессор, заведующий научно-исследовательским центром, заведующий кафедрой нормальной физиологии

Смоленск

Andrey V. Evseev — D. Sc. in Medicine, Professor, Head of the Research Center, Head of the Department of Normal Physiology

Smolensk

АвдееваТ. Г.AvdeevaТ. G.

Авдеева Татьяна Григорьевна — д. м. н., профессор кафедры поликлинической педиатрии

Смоленск

Tatyana G. Avdeeva — D. Sc. in Medicine, Professor of the Department of Outpatient Pediatrics

Smolensk

ЛегоньковаТ. И.LegonkovaТ. I.

Легонькова Татьяна Ивановна — д. м. н., профессор, заведующая кафедрой пропедевтики детских болезней и факультетской педиатрии

Смоленск

Tatyana I. Legonkova — D. Sc. in Medicine, Professor, Head of the Department of Propaedeutics of Childhood Diseases and Faculty Pediatrics

Smolensk

ЖарковаЛ. П.ZharkovaL. Р.

Жаркова Людмила Павловна — д. м. н., профессор кафедры клинической фармакологии

Смоленск

Lyudmila P. Zharkova — D. Sc. in Medicine, Professor, Department of clinical pharmacology

Smolensk

ФГБОУ ВО «Смоленский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSmolensk State Medical University of the Ministry of Health of the Russian FederationRussian Federation202326122023687-87882Copyright © Данилов А.И., Евсеев А.В., Авдеева Т.Г., Легонькова Т.И., Жаркова Л.П., 20232023Данилов А.И., Евсеев А.В., Авдеева Т.Г., Легонькова Т.И., Жаркова Л.П.Danilov А.I., Evseev А.V., Avdeeva Т.G., Legonkova Т.I., Zharkova L.Р.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1066

Инфекционный эндокардит у детей — редкое заболевание, но зачастую с крайне серьёзным прогнозом. Наиболее частым фактором риска инфекционного эндокардита у данной категории пациентов является наличие в анамнезе врожденного порока сердца. Вместе с тем, в последнее время среди предрасполагающих причин всё чаще отмечаются нарушение целостности периферического сосудистого русла за счёт проведения инвазивных диагностических и терапевтических медицинских процедур, а также тяжело протекающие соматические заболевания. В соответствии с разработанными рекомендациями, назначение антибактериальной терапии при инфекционном эндокардите должно основываться на этиотропной направленности. Учитывая указанные обстоятельства, в статье представлен обзор данных, отражающий вопросы этиологии и выбора антибактериальной терапии при инфекционном эндокардите в педиатрической практике.

Infective endocarditis in children is a rare disease, which often has an extremely serious prognosis. The most common risk factor for infective endocarditis in this category of patients is the history of congenital heart disease. At the same time, currently, the disruption of the integrity of the peripheral vascular bed is increasingly noted, among the predisposing causes, due to invasive diagnostic and therapeutic medical procedures, as well as severe somatic diseases. In accordance with the developed recommendations, the appointment of antibacterial therapy for infective endocarditis should be based on etiotropic orientation. Taking these circumstances into account, the article presents an overview of the data reflecting the issues of etiology and choice of antibacterial therapy for infective endocarditis in pediatric practice.

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The authors declare that there are no conflicts of interest present.