antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2023-68-11-12-67-74antibiotics-1100Research ArticleОБЗОРЫREVIEWSУдлинение интервала QT при лечении лекарственно-устойчивого туберкулёзаQT-Interval Prolongation in the Treatment of Drug-Resistant Tuberculosishttps://orcid.org/0000-0003-3383-7723КукурикаА. В.KukurikaA. V.

Кукурика Анастасия Владимировна — специалист центра социально-значимых инфекций

Москва

Anastasiia V. Kukurika — specialist at the Center for Socially Significant Infections

Moscow

ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний»РоссияNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian Federation2023251220236811-126774Copyright © Кукурика А.В., 20242024Кукурика А.В.Kukurika A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1100

В обзоре проанализированы научные статьи, руководства и результаты клинических испытаний о влиянии фторхинолонов, бедаквилина, нитроимидазолов и клофазимина на удлинение интервала QT. Представлена значимость своевременного и регулярного мониторинга кардиотоксичности и важность продолжения клинических испытаний для открытия противотуберкулёзных препаратов с удовлетворительным профилем безопасности.

The review analyzes the research articles, guidelines, and clinical trial results on the effect of fluoroquinolones, bedaquiline, nitroimidazoles, and clofazimine on QTc prolongation. The importance of timely and regular monitoring of cardiotoxicity and the importance of continuing clinical trials for the discovery of anti-tuberculosis drugs with a satisfactory safety profile are presented.

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The authors declare that there are no conflicts of interest present.