antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2024-69-1-2-65-73CYIUUWantibiotics-1110Research ArticleОБЗОРЫREVIEWSВакцинопрофилактика инфекций и активность иммуновоспалительных ревматических заболеваний: pro et contraVaccinoprophylaxis of infections and activity of immuno-inflammatory rheumatic diseases: pro et contrahttps://orcid.org/0000-0001-7091-2054БеловБ. С.BelovB. S.

Белов Борис Сергеевич — д. м. н., заведующий лабораторией коморбидных инфекций и вакцинопрофилактики

Каширское шоссе, д. 34А, НИИ ревматологии им. В. А. Насоновой, г. Москва, 115522

ResearcherID: ABD-2219-2020. Scopus Author ID: 7004592537

Boris S. Belov — D. Sc. in Medicine, Head of the Laboratory of Comorbid Infections and Vaccine Prevention

 34A Kashirskoe highway, V. A. Nasonova Research Institute of Rheumatology, Moscow, 115522

ResearcherID: ABD-22192020. Scopus Author ID: 7004592537 

belovbor@yandex.ruhttps://orcid.org/0000-0003-4327-6720МуравьеваН. В.MuravyevaN. V.

Муравьева Наталья Валерьевна — к. м. н., старший научный сотрудник лаборатории коморбидных инфекций и вакцинопрофилактики

Москва

ResearcherID: AAF-4853-2021. Scopus Author ID: 57210263706 

Natalia V. Muravyeva — Ph. D. in Medicine, Senior Researcher at the Laboratory of Comorbid Infections and Vaccine Prevention

Moscow

ResearcherID: AAF-4853-2021. Scopus Author ID: 57210263706 

   

ФГБНУ НИИ ревматологии им. В. А. НасоновойРоссияV. A. Nasonova Research Institute of RheumatologyRussian Federation202416042024691-26573Copyright © Белов Б.С., Муравьева Н.В., 20242024Белов Б.С., Муравьева Н.В.Belov B.S., Muravyeva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1110

В современных условиях пациенты с иммуновоспалительными ревматическими заболеваниями (ИВРЗ) подвергаются значимому риску заболеваемости гриппом, пневмококковыми и герпес-вирусными инфекциями, а также COVID-19, в ряде случаев — с летальным исходом. Наиболее эффективным способом предупреждения инфекционных заболеваний и снижения смертности от них является вакцинопрофилактика, проведение которой рекомендуется в неактивной фазе ИВРЗ. Однако у ряда больных ИВРЗ имеет место рефрактерное течение болезни, и достижение ремиссии у них оказывается трудновыполнимой задачей, в связи с чем проблема вакцинации таких пациентов на фоне активного воспалительного процесса весьма актуальна. В обзоре проанализированы данные по применению вакцинопрофилактики вышеуказанных инфекций в активной фазе ИВРЗ. В подавляющем большинстве случаев вакцинопрофилактика была безопасной и не приводила к обострению ИВРЗ или развитию новых аутоиммунных феноменов.

 

In modern conditions, patients with immuno-inflammatory rheumatic diseases (IIRD) are at significant risk of influenza, pneumococcal and herpes viral infections, as well as COVID-19, in some cases fatal. The most effective way to prevent infectious diseases and reduce mortality from them is vaccination, which is recommended in the inactive phase of IIRD. However, a number of patients with IIRD have a refractory course of the disease, and achieving remission in them turns out to be a difficult task, and therefore the problem of vaccination of such patients against the background of an active inflammatory process is very relevant. The review analyzes data on the use of vaccine prophylaxis for the above infections in the active phase of IIRD. In the vast majority of cases, vaccination was safe and did not lead to an exacerbation of IIRD or the development of new autoimmune phenomena.

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The authors declare that there are no conflicts of interest present.