antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2024-69-5-6-63-71antibiotics-1148Research ArticleОБЗОРЫREVIEWSМеханизмы антифаговой защиты прокариотовMechanisms of Antiphage Defense in Prokaryoteshttps://orcid.org/0000-0001-8607-2395ДаудоваА. Д.DaudovaА. D.

Даудова Адиля Джигангировна — к. м. н., доцент кафедры микробиологии и вирусологии

Астрахань

Adilya D. Daudova — Ph. D. in Medicine, Associate Professor of the Department of Microbiology and Virology

Astrakhan

https://orcid.org/0000-0003-0428-2570ДеминаЮ. З.DeminaYu. Z.

Демина Юлия Заурбековна — старший преподаватель кафедры микробиологии и вирусологии

Астрахань

Yuliya Z. Demina — Senior lecturer of the Department of Microbiology and Virology

Astrakhan

https://orcid.org/0000-0003-0536-8149АбдрахмановаР. О.AbdrakhmanovaR. O.

Абдрахманова Радмила Охасовна — ассистент кафедры микробиологии и вирусологии

Астрахань

Radmila O. Abdrakhmanova — Assistant of the Department of Microbiology and Virology

Astrakhan

https://orcid.org/0009-0008-8578-7303БаеваГ. Р.BaevaG. R.

Баева Гюзель Ренатовна — младший научный сотрудник Научно-исследовательского центра

Астрахань

Guzel R. Baeva — Junior researcher

Astrakhan

https://orcid.org/0000-0003-0838-7353РубальскаяТ. С.RubalskaiaT. S.

Рубальская Татьяна Сергеевна — руководитель лаборатории прикладной иммунохимии

Москва

Tatiana S. Rubalskaia — Head of the Laboratory of Applied Immunochemistry

Moscow

https://orcid.org/0000-0003-2998-2864ЯсенявскаяА. Л.YasenyavskayaA. L.

Ясенявская Анна Леонидовна — к. м. н., доцент, руководитель Научно-исследовательского центра; доцент кафедры фармакогнозии, фармацевтической технологии и биотехнологии

Астрахань

Anna L. Yasenyavskaya — Ph. D. in Medicine, Associate Professor, Head of the Research Center, Associate Professor of the Department of Pharmacognosy, Pharmaceutical Technology, and Biotechnology

Astrakhan

https://orcid.org/0000-0002-2904-9276РубальскийО. В.RubalskyO. V.

Рубальский Олег Васильевич — д. м. н., профессор, заведующий кафедрой микробиологии и вирусологии

Астрахань

Oleg V. Rubalsky — D. Sc. in Medicine, Professor, Head of the Department of Microbiology and Virology

Astrakhan

https://orcid.org/0000-0001-5336-4455СамотруеваМ. А.SamotruevaM. A.

Самотруева Марина Александровна — д. м. н., профессор, заведующая кафедрой фармакогнозии, фармацевтической технологии и биотехнологии

Астрахань

Marina A. Samotrueva — D. Sc. in Medicine, Professor, Head of the Department of Pharmacognosy, Pharmaceutical Technology, and Biotechnology

Astrakhan

Астраханский государственный медицинский университетРоссияAstrakhan State Medical University of the Ministry of Health of RussiaRussian FederationФБУН «Московский научно-исследовательский институт эпидемиологии и микробиологии» им. Г. Н. Габричевского РоспотребнадзораРоссияG. N. Gabrichevsky Research Institute for Epidemiology and Microbiology of the Federal Service for the Oversight of Consumer Protection and WelfareRussian FederationАстраханский государственный медицинский университетРоссияAstrakhan State Medical University of the Ministry of Health of the Russian FederationRussian Federation202403102024695-66371Copyright © Даудова А.Д., Демина Ю.З., Абдрахманова Р.О., Баева Г.Р., Рубальская Т.С., Ясенявская А.Л., Рубальский О.В., Самотруева М.А., 20242024Даудова А.Д., Демина Ю.З., Абдрахманова Р.О., Баева Г.Р., Рубальская Т.С., Ясенявская А.Л., Рубальский О.В., Самотруева М.А.Daudova А.D., Demina Y.Z., Abdrakhmanova R.O., Baeva G.R., Rubalskaia T.S., Yasenyavskaya A.L., Rubalsky O.V., Samotrueva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1148

Глобализация проблемы формирования поли- и панрезистентных к известным противомикробным препаратам штаммов бактерий создаёт высокие риски в сфере здравоохранения. Угроза возвращения в «доантибиотическую» эру диктует необходимость поиска альтернативных путей антибактериальной терапии. Фаготерапия, основанная на использовании естественного, широко распространённого в окружающей среде, доступного антимикробного агента, снова становится актуальной. В статье освещены механизмы противовирусной защиты прокариотов на различных этапах взаимодействия вируса и клетки-мишени. Раскрытие секретов противостояния бактерий и вирусов, их коэволюции необходимо для повышения эффективности фаготерапии и разработки современных средств преодоления резистентности бактерий к антимикробным средствам.

The globalization of the problem of the formation of bacterial strains poly- and pan-resistant to known antimicrobial drugs creates high risks in the healthcare sector. The threat of a return to the «pre-antibiotic» era dictates the need to search for alternative forms of antibacterial therapy. Phage therapy, based on the use of a natural, widely distributed in the environment, accessible antimicrobial agent, is again becoming relevant. The article highlights the mechanisms of antiviral protection of prokaryotes at various stages of interaction between the virus and the target cell. Revealing the secrets of the confrontation between bacteria and viruses, their co-evolution is necessary to increase the effectiveness of phage therapy and develop modern means of overcoming bacterial resistance to antimicrobial agents.

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The authors declare that there are no conflicts of interest present.