antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2024-69-9-10-71-85JCQLUNantibiotics-1188Research ArticleОБЗОРЫREVIEWSПрименение бактериоцинов, включая микроцины: настоящее и будущееApplication of Bacteriocins in Practice, Including Microcins: the Present and the FutureТеймуразовМ. Г.TeimurazovM. G.

Теймуразов Марат Георгиевич — к. б. н., старший научный сотрудник лаборатории антимикробных препаратов отдела молекулярной микробиологии

Оболенск 

Marat G. Teimurazov — Ph. D. in Biology, Senior Researcher of the Laboratory of Antimicrobial Drugs, Department of Molecular Microbiology

Obolensk 

marat_teimurazov@mail.ruКоваленкоИ. М.KovalenkoI. M.

Коваленко Илья Михайлович — младший научный сотрудник лаборатории антимикробных препаратов отдела молекулярной микробиологии

Оболенск 

Ilya M. Kovalenko — Junior Researcher of the Laboratory of Antimicrobial Drugs, Department of Molecular Microbiology

Obolensk 

https://orcid.org/0000-0002-2829-5117ХохловаО. Е.KhokhlovaO. E.

Хохлова Ольга Евгеньевна — д. б. н., доцент, главный научный сотрудник лаборатории антимикробных препаратов отдела молекулярной микробиологии

Оболенск 

Olga E. Khokhlova — D. Sc. in Biology, Associate Professor, Chief Researcher of the Laboratory of Antimicrobial Drugs, Department of Molecular Microbiology

Obolensk 

ФБУН Государственный научный центр прикладной микробиологии и биотехнологии РоспотребнадзораРоссияState Research Center for Applied Microbiology and Biotechnology of RospotrebnadzorRussian Federation202425102024699-107185Copyright © Теймуразов М.Г., Коваленко И.М., Хохлова О.Е., 20252025Теймуразов М.Г., Коваленко И.М., Хохлова О.Е.Teimurazov M.G., Kovalenko I.M., Khokhlova O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1188

В последние десятилетия бактериоцины активно изучают как антимикробные соединения. Бактериоцины, в основном, использовались в качестве пищевых консервантов, однако в настоящее время они вызывают повышенный интерес как потенциальные клинические антимикробные препараты и возможные иммуномодулирующие агенты. Инфекции, вызванные бактериями, устойчивыми к антибиотикам, были объявлены глобальной угрозой общественному здравоохранению. Бактериоцины представляют собой потенциальное решение этой всемирной угрозы благодаря их широкому или узкому спектру действия против бактерий, устойчивых к антибиотикам. В частности, несмотря на их роль как природных альтернатив химическим консервантам в обеспечении безопасности пищевых продуктов, низин остаётся единственным бактериоцином, одобренным регулирующими органами в качестве пищевого консерванта. В статье освещены данные о безопасности применения бактериоцинов и их возможной токсичности, что может представлять барьер для более широкого их использования в медицине и отраслях промышленности. В статье описаны последние тенденции в разработке препаратов на основе бактериоцинов, их эффективности, спектре антимикробной активности и механизмах воздействия на макроорганизмы.

In recent decades, bacteriocins have been actively studied as antimicrobial compounds. Bacteriocins have been primarily used to preserve food, but they are currently of increasing interest as potential clinical antimicrobial agents and possible immunomodulatory agents. Infections caused by antibiotic-resistant bacteria have been declared a global public health threat. Bacteriocins represent a potential solution to this worldwide threat due to their broad- or narrow-spectrum activity against antibiotic-resistant bacteria. In particular, despite their role as natural alternatives to chemical preservation in ensuring food safety, nisin remains the only bacteriocin approved by regulatory authorities for food preservation. The article highlights data on the safety of bacteriocins and their possible toxicity, which may become a barrier to their wider use in medicine and industry. The article describes the latest trends in the development of bacteriocin-based drugs, their effectiveness, spectrum of antimicrobial activity, and mechanisms of action on microorganisms.

антимикробные пептидыбактериоцинымикроцинымеханизм действияспектр антимикробной активностипрепаратыAntimicrobial peptidesbacteriocinsmicrocinsmechanism of actionspectrum of antimicrobial activitydrugsРабота проведена в рамках Отраслевой программы Роспотребнадзора НИР087 «Характеристика генетической структуры и получение микроцина L против антибиотикорезистентных грамотрицательных бактериальных патогенов».ReferencesMin K. H., Kim K. H., Ki M.-R., Pack S. P. Antimicrobial peptides and their biomedical applications: a review. Antibiotics. 2024; 13: 794. doi: 10.3390/antibiotics13090794.Min K. H., Kim K. H., Ki M.-R., Pack S. P. Antimicrobial peptides and their biomedical applications: a review. Antibiotics. 2024; 13: 794. doi: 10.3390/antibiotics13090794.Corrêa J. A. F., de Melo Nazareth T., da Rocha G. F., Luciano F. B. Bioactive antimicrobial peptides from food proteins: perspectives and challenges for controlling foodborne pathogens. 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The authors declare that there are no conflicts of interest present.