antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2024-69-9-10-91-107NQMBCBantibiotics-1190Research ArticleОБЗОРЫREVIEWSКардиотоксичность противоопухолевых средствCardiotoxicity of Anticancer Drugshttps://orcid.org/0000-0002-8182-5084МайбородинИ. В.MaiborodinI.

Майбородин Игорь Валентинович — д. м. н., профессор, главный научный сотрудник лаборатории инвазивных медицинских технологий

Новосибирск 

Igor Maiborodin — D. Sc. in Medicine, Professor, Chief Researcher at the Laboratory of Invasive Medical Technologies, Center of New Medical Technologies

Novosibirsk 

imai@mail.ruhttps://orcid.org/0009-0008-1839-071XШумейкинаА. О.ShumeikinaA. O.

Шумейкина Анастасия Олеговна — аспирант по специальности «онкология»

Новосибирск 

Anastasia O. Shumeikina — Postgraduate Student in the Specialty «Oncology»

Novosibirsk 

https://orcid.org/0000-0002-5169-6373МайбородинаВ. И.MaiborodinaV. I.

Майбородина Виталина Игоревна — д. м. н., ведущий научный сотрудник лаборатории инвазивных медицинских технологий

Новосибирск 

Vitalina I. Maiborodina — D. Sc. in Medicine, Leading Researcher, Laboratory of Invasive Medical Technologies

Novosibirsk 

https://orcid.org/0000-0003-0687-0894КрасильниковС. Э.KrasilnikovS. E.

Красильников Сергей Эдуардович — д. м. н., профессор, главный научный сотрудник

Новосибирск 

Sergey E. Krasilnikov — D. Sc. in Medicine, Professor, Chief Researcher

Novosibirsk 

Федеральное государственное бюджетное учреждение науки «Институт химической биологии и фундаментальной медицины СО РАН»РоссияInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of The Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр фундаментальной и трансляционной медицины» Министерства науки и высшего образования Российской ФедерацииРоссияFederal Research Center for Fundamental and Translational Medicine of the Ministry of Science and Higher Education of the Russian FederationRussian Federation202425102024699-1091107Copyright © Майбородин И.В., Шумейкина А.О., Майбородина В.И., Красильников С.Э., 20252025Майбородин И.В., Шумейкина А.О., Майбородина В.И., Красильников С.Э.Maiborodin I., Shumeikina A.O., Maiborodina V.I., Krasilnikov S.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1190

С целью изучения последних данных по кардиотоксичности противоопухолевых препаратов проведён анализ литературы 2022 г. Многочисленность данных по патогенезу кардиотоксичности даже одного химиотерапевтического средства свидетельствует о многофакторности воздействия и об особенностях индивидуальной чувствительности каждого пациента к тому или иному препарату. В связи с многофакторностью патогенеза кардиотоксичности, клинические проявления этого осложнения также многочисленны, при этом следует учитывать, что онкологические пациенты ещё до развития опухоли могли страдать различными сердечно-сосудистыми заболеваниями, и что прогрессирование рака даже без терапевтического воздействия или до него может являться причиной неблагоприятных реакций со стороны сердца. Для выявления таких процессов необходимо наблюдение за кардиоонкологическими больными в динамике. При проведении консервативного лечения рака и развитии побочных эффектов полная отмена всех лекарственных средств невозможна, приходится продолжать терапию, проводить повторные её курсы, нередко в течение всей жизни пациента. В связи с этим необходимы методы уменьшения выраженности кардиотоксического эффекта, подавления неблагоприятного влияния на миокард противоопухолевых средств, по-прежнему остаются актуальными поиск и разработка эффективных методов профилактики и лечения кардиотоксичости препаратов для химиотерапии. Своевременное выявление, а значит и предупреждение, и уменьшение степени повреждающего воздействия, начинающегося кардиотоксического эффекта при использовании средств для химиотерапии рака возможно только при тесном сотрудничестве онкологов и кардиологов.

An analysis of the literature for 2022 was carried out in order to study the latest data on the cardiotoxicity of antitumor drugs. The abundance of data on the pathogenesis of cardiotoxicity of even a single chemotherapeutic agent indicates the multifactorial effect and the characteristics of the individual sensitivity of each patient to a particular drug. Due to the multifactorial nature of the pathogenesis of cardiotoxicity, the clinical manifestations of this complication are also numerous. It should be taken into account that oncological patients could have suffered from various cardiovascular diseases even before tumor development, and that cancer progression even without therapeutic intervention, or before it, can cause cardiac side effects. To identify such processes, it is necessary to monitor cardio-oncological patients in dynamics. When conducting conservative cancer treatment and in the event of the development of side effects, the complete cancellation of treatment is impossible, as it is necessary to continue the therapy, as well as repeat its courses, often throughout the patient's life. In this regard, methods are needed to reduce the severity of the cardiotoxic effect, as well as suppress the adverse effects of anticancer drugs on the myocardium, and the search and development of effective methods for the prevention and treatment of cardiotoxicity of chemotherapy drugs are still relevant. Timely detection, and hence, prevention, as well as reduction of the degree of damaging effects of the beginning cardiotoxic effect when using cancer chemotherapy agents is possible only with close cooperation between oncologists and cardiologists.

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The authors declare that there are no conflicts of interest present.