antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2024-69-9-10-108-132POUZCXantibiotics-1191Research ArticleОБЗОРЫREVIEWSАнализ проблемы антибиотикорезистентности в агропромышленном комплексеAnalysis of the Antibiotic Resistance Problem in the Agricultural Sectorhttps://orcid.org/0000-0002-2598-913XОлсуфьеваЕ. Н.OlsufyevaE. N.

Олсуфьева Евгения Николаевна — д. х. н., профессор, главный научный сотрудник Лаборатории химической трансформации антибиотиков

Scopus Author ID: 35595443300. WOS Research ID: B-1230-2017. РИНЦ Ausor ID: 57864

Москва 

Evgenia N. Olsufyeva — D. Sc. in Chemistry, Professor, Chief Researcher at the Laboratory of Chemical Transformation of Antibiotics

Scopus Author ID: 35595443300. WOS Research ID: B-1230-2017. РИНЦ Ausor ID: 57864

Moscow 

eolsufeva@list.ruhttps://orcid.org/0000-0003-2801-380XЯнковскаяВ. С.YankovskayaV. S.

Янковская Валентина Сергеевна — д. т. н., доцент кафедры управления качеством и товароведения продукции

ResearcherID: AAR-2725-2021. AuthorID: 562520. ScopusAuthor ID: 57195148578

Москва 

Valentina S. Yankovskaya — D. Sc. in Technical Sciences, Associate Professor of the Department of Quality Management and Commodity Science

ResearcherID: AAR-2725-2021. AuthorID: 562520. ScopusAuthor ID: 57195148578

Moscow 

ФГБНУ «Научно-исследовательский институт по изысканию новых антибиотиков им. Г. Ф. Гаузе» (ФГБНУ «НИИНА»)РоссияGause Institute of New AntibioticsRussian FederationФГБОУ ВО Российский государственный аграрный университет — МСХА им. К. А. Тимирязева (РГАУ-МСХА им. К. А. Тимирязева)РоссияRussian State Agrarian University — Moscow Timiryazev Agricultural AcademyRussian Federation202425102024699-10108132Copyright © Олсуфьева Е.Н., Янковская В.С., 20252025Олсуфьева Е.Н., Янковская В.С.Olsufyeva E.N., Yankovskaya V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1191

Устойчивость к противомикробным препаратам является одной из основных глобальных угроз общественному здравоохранению и развитию. Проблема антибиотикорезистентности возникла в результате широкого и бесконтрольного применения противомикробных препаратов в медицине и сельском хозяйстве. Противомикробные препараты, включая антибиотики, широко применяются в современном сельском хозяйстве для лечения животных, птиц и других домашних животных, а также в пищевой промышленности. Уже в начале эпохи открытия антибиотиков было обнаружено снижение чувствительности бактерий к некоторым классам антибиотиков, которое впоследствии в ряде случаев трансформировалась в множественную лекарственную устойчивость. Резистентность микроорганизмов зависит от структуры антибиотика и связана с механизмом его антибактериальной активности. В обзоре рассмотрены свойства критически важных с точки зрения проблемы устойчивости различных групп антибиотиков, предназначенных для лечения, профилактики и стимулирования роста сельскохозяйственных животных. Обсуждены также возможности применения в ветеринарии методов, альтернативных антибиотикотерапии.

Antimicrobial resistance is a major global threat to public health and development. The problem of antibiotic resistance arose as a result of widespread and uncontrolled use of antimicrobial drugs in medicine and agriculture. Antimicrobials, including antibiotics, are widely used in modern agriculture to treat animals, birds, and other domestic animals, as well as in the food industry. A decrease in the sensitivity of bacteria to certain classes of antibiotics was discovered as early as the very beginning of the antibiotic discovery era, which subsequently, in some cases, transformed into multidrug resistance. The resistance of microorganisms depends on the structure of the antibiotic and is associated with the mechanism of its antibacterial activity. The review examines the properties of various groups of antibiotics that are critically important in terms of the resistance problem, intended for the treatment, prevention, and growth stimulation of farm animals. The possibilities of using methods alternative to antibiotic therapy in veterinary medicine were also discussed.

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The authors declare that there are no conflicts of interest present.