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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/0235-2990-2024-69-11-12-101-109</article-id><article-id custom-type="edn" pub-id-type="custom">BVSMZU</article-id><article-id custom-type="elpub" pub-id-type="custom">antibiotics-1212</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Биоразнообразие и антимикробный потенциал ацидофильных и ацидотолерантных актиномицетов</article-title><trans-title-group xml:lang="en"><trans-title>Biodiversity and Antimicrobial Potential of Acidophilic and Acidotolerant Actinomycetes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-6715-8166</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чумак</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chumak</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чумак Анастасия Владимировна — аспирант, инженер лаборатории таксономического изучения и коллекции культур микроорганизмов.</p><p>Москва</p></bio><bio xml:lang="en"><p>Anastasia V. Chumak — graduate student, engineer at the Department of Taxonomic Research and Culture Collection of Microorganisms.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0063-4922</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синёва</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sineva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синёва Ольга Николаевна — к. б. н., научный сотрудник лаборатории таксономического изучения и коллекции культур микроорганизмов.</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga N. Sineva — Ph. D. in Biology, Researcher at the Department of Taxonomic Research and Culture Collection of Microorganisms.</p><p>Moscow</p></bio><email xlink:type="simple">olga.sineva81@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБНУ «Научно-исследовательский институт по изысканию новых антибиотиков им. Г.Ф. Гаузе»<country>Россия</country></aff><aff xml:lang="en">Gause Institute of New Antibiotics<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2025</year></pub-date><volume>69</volume><issue>11-12</issue><fpage>101</fpage><lpage>109</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чумак А.В., Синёва О.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Чумак А.В., Синёва О.Н.</copyright-holder><copyright-holder xml:lang="en">Chumak A.V., Sineva O.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/1212">https://www.antibiotics-chemotherapy.ru/jour/article/view/1212</self-uri><abstract><p>Распространение антибиотикорезистентности патогенных микроорганизмов — одна из главных проблем современной медицины. В связи с особенностями метаболизма экстремофильных микроорганизмов, поиск продуцентов новых антимикробных соединений среди экстремофильных актиномицетов вполне обоснован. В обзоре рассмотрены ацидофильные и ацидотолерантные актиномицеты, которые являются неотъемлемой частью микробиомов кислых почв и, как показывают исследования, обладают высоким антимикробным потенциалом.</p></abstract><trans-abstract xml:lang="en"><p>The spread of antibiotic resistance in pathogenic microorganisms is one of the main problems of modern medicine. Given the unique metabolic properties of extremophilic microorganisms, the search for producers of new antimicrobial compounds among extremophilic actinomycetes is reasonably justified. The review examines acidophilic and acidotolerant actinomycetes, which are an integral part of the microbiomes of acidic soils and, as studies show, have high antimicrobial potential.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ацидофильные актиномицеты</kwd><kwd>биоразнообразие</kwd><kwd>антимикробный потенциал</kwd><kwd>вторичные метаболиты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acidophilic actinomycetes</kwd><kwd>biodiversity</kwd><kwd>antimicrobial potential</kwd><kwd>secondary metabolites</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Работа выполнена в рамках государственного задания ФГБНУ «Научно-исследовательский институт по изысканию новых антибиотиков им. Г. Ф. Гаузе»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barka E. A., Vatsa P., Sanchez L., Gaveau-Vaillant N., Jacquard C., Klenk H.-P. 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