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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/0235-2990-2025-70-1-2-76-87</article-id><article-id custom-type="edn" pub-id-type="custom">PRHJIX</article-id><article-id custom-type="elpub" pub-id-type="custom">antibiotics-1226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Сенсорные системы для оценки восприимчивости бактерий к антибиотикам</article-title><trans-title-group xml:lang="en"><trans-title>Sensor Systems for Assessing Bacterial Susceptibility to Antibiotics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0541-0020</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гулий</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Guliy</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Ивановна Гулий, д. б. н., профессор, ведущийнаучный сотрудник</p><p>лаборатория биохимии</p><p>Саратов</p></bio><bio xml:lang="en"><p>Olga I. Guliy, D. Sc. in Biology, Professor, Leading researcher</p><p>Biochemistry Laboratory</p><p>Saratov</p></bio><email xlink:type="simple">guliy_olga@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0665-1846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караваева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karavaeva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Александровна Караваева, к. б. н., научный сотрудник</p><p>лаборатория биохимии</p><p>Саратов</p></bio><bio xml:lang="en"><p>Olga A. Karavaeva, Ph. D. in Biology, Researcher</p><p>Biochemistry Laboratory </p><p>Saratov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт биохимии и физиологии растений и микроорганизмов, ФИЦ «Саратовский научный центр РАН» (ИБФРМ РАН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochemistry and Physiology of Plants and Microorganisms — Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>09</day><month>06</month><year>2025</year></pub-date><volume>70</volume><issue>1-2</issue><fpage>76</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гулий О.И., Караваева О.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гулий О.И., Караваева О.А.</copyright-holder><copyright-holder xml:lang="en">Guliy O.I., Karavaeva O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/1226">https://www.antibiotics-chemotherapy.ru/jour/article/view/1226</self-uri><abstract><p>   Чрезмерное и порой неправильное использование антибиотиков приводит к появлению штаммов, обладающих множественной лекарственной устойчивостью. Устойчивые к антибиотикам патогены являются серьёзной проблемой здравоохранения в повседневной клинической практике, что влечёт за собой тяжёлые экономические последствия, вследствие увеличения затрат на лечение. Своевременное определение чувствительности к противомикробным препаратам при бактериальной инфекции обеспечивает точность назначения препаратов, сокращает время лечения и помогает свести к минимуму распространение инфекций, устойчивых к антибиотикам. Основная проблема при анализе антибиотикочувствительности бактерий заключается в том, что не существует достаточно быстрых диагностических тестов, которые позволили бы правильно назначить антибиотики на месте оказания медицинской помощи. С помощью традиционных методов для определения чувствительности бактерий к антибиотикам требуется минимум 24 ч. Поэтому актуальным является развитие экспресс-методов определения антибактериальной устойчивости, особенно с помощью биосенсорных систем. В работе проведён краткий анализ проблематики антибиотикочувствительности бактерий в мире и представлены основные механизмы её развития, а также описана перспективность сенсорных методов для оценки антибиотикорезистентности бактерий.</p></abstract><trans-abstract xml:lang="en"><p>   Excessive and sometimes inappropriate use of antibiotics leads to the emergence of multidrug-resistant (MDR) strains. Antibiotic-resistant pathogens are a major public health problem in routine clinical practice and have severe economic consequences due to increased treatment costs. Timely testing of antimicrobial susceptibility for bacterial infections ensures accurate prescribing, reduces treatment time, and helps minimize the spread of antibiotic-resistant infections. The main problem with antibiotic susceptibility testing is that there are not enough fast diagnostic tests to allow appropriateantibiotic prescribing at the point of care. Using traditional methods, determining the sensitivity of bacteria to antibiotics requires a minimum of 24 hours. Therefore, the development of express methods for determining antibacterial resistance, especially using biosensor systems, is relevant. The work provides a brief analysis of the problems of antibiotic sensitivity of bacteria in the world and presents the main mechanisms of its development, as well as describes the prospects of sensor methods for assessing the antibiotic resistance of bacteria.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>микроорганизмы</kwd><kwd>антибиотикочувствительность</kwd><kwd>сенсорные системы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>microorganisms</kwd><kwd>antibiotic sensitivity</kwd><kwd>sensory systems</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке Российского научного Фонда, проект № 24-24-00309</funding-statement><funding-statement xml:lang="en">The work was carried out with the financial support of the Russian Scientific Foundation, project No. 24-24-00309</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lee A. S., de Lencastre H., Garau J., Kluytmans J., Malhotra-Kumar S., Peschel A. et al. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 2018; 4 (1): 18033. doi: 10.1038/nrdp.2018.33.</mixed-citation><mixed-citation xml:lang="en">Lee A. S., de Lencastre H., Garau J., Kluytmans J., Malhotra-Kumar S., Peschel A. et al. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 2018; 4 (1): 18033. doi: 10.1038/nrdp.2018.33.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang F., Cheng W. The mechanism of macterial resistance and potential bacteriostatic strategies. Antibiotics. 2022; 11 (9): 1215. doi: 10.3390/antibiotics11091215.</mixed-citation><mixed-citation xml:lang="en">Zhang F., Cheng W. The mechanism of macterial resistance and potential bacteriostatic strategies. Antibiotics. 2022; 11 (9): 1215. doi: 10.3390/antibiotics11091215.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Roope L. S. J., Smith R. D., Pouwels K. B., Buchanan J., Abel L., Eibich P. et al. The challenge of antimicrobial resistance: What economics can contribute. Science. 2019; 364 (6435): eaau4679. doi: 10.1126/science.aau4679.</mixed-citation><mixed-citation xml:lang="en">Roope L. S. J., Smith R. D., Pouwels K. B., Buchanan J., Abel L., Eibich P. et al. The challenge of antimicrobial resistance: What economics can contribute. Science. 2019; 364 (6435): eaau4679. doi: 10.1126/science.aau4679.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Theuretzbacher U., Gottwalt S., Beyer P., Butler M., Czaplewski L., Lienhardt C. et al. Analysis of the clinical antibacterial and antituberculosis pipeline. Lancet Infect. Dis. 2019; 19 (2): e40-e50. doi: 10.1016/s1473-3099(18)30513-9.</mixed-citation><mixed-citation xml:lang="en">Theuretzbacher U., Gottwalt S., Beyer P., Butler M., Czaplewski L., Lienhardt C. et al. Analysis of the clinical antibacterial and antituberculosis pipeline. Lancet Infect. Dis. 2019; 19 (2): e40-e50. doi: 10.1016/s1473-3099(18)30513-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Antibiotic Resistance Threats in the United States, 2019; Antimicrobial Resistance. Tackling the Burden in the European Union, 2019. U.S. Department of Health and Human Services, CDC; 2019. Atlanta, GA. Available from: www.cdc.gov/DrugResistance/Biggest-Threats.html. doi: 10.15620/cdc:82532.</mixed-citation><mixed-citation xml:lang="en">Antibiotic Resistance Threats in the United States, 2019; Antimicrobial Resistance. Tackling the Burden in the European Union, 2019. U.S. Department of Health and Human Services, CDC; 2019. Atlanta, GA. Available from: www.cdc.gov/DrugResistance/Biggest-Threats.html. doi: 10.15620/cdc:82532.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rossen J. W.A., Tedim A. P., Murray A. K. The novel coronavirus COVID-19 outbreak: global implications for antimicrobial resistance. Front Microbiol. 2020; 1: 1020. doi: 10.3389/fmicb.2020.01020.</mixed-citation><mixed-citation xml:lang="en">Rossen J. W.A., Tedim A. P., Murray A. K. The novel coronavirus COVID-19 outbreak: global implications for antimicrobial resistance. Front Microbiol. 2020; 1: 1020. doi: 10.3389/fmicb.2020.01020.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rehman S. A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic. J Infect Public Health. 2023; 16 (4): 611-617. doi: 10.1016/j.jiph.2023.02.021.</mixed-citation><mixed-citation xml:lang="en">Rehman S. A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic. J Infect Public Health. 2023; 16 (4): 611-617. doi: 10.1016/j.jiph.2023.02.021.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">De Oliveira D. M. P., Forde B. M., Kidd T. J., Harris P. N. A., Schembri M. A., Beatson S. A. et al. Antimicrobial Resistance in ESKAPE Pathogens. Clin Microbiol Rev. 2020; 33 (3): e00181-19. doi: 10.1128/cmr.00181-19.</mixed-citation><mixed-citation xml:lang="en">De Oliveira D. M. P., Forde B. M., Kidd T. J., Harris P. N. A., Schembri M. A., Beatson S. A. et al. Antimicrobial Resistance in ESKAPE Pathogens. Clin Microbiol Rev. 2020; 33 (3): e00181-19. doi: 10.1128/cmr.00181-19.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Central Asian and European Surveillance of Antimicrobial Resistance (CAESAR). World Health Organization Regional Office for Europe. 2016. Available from: http://www.euro.who.int/en/health-topics/disease-prevention/antimicrobial-resistance/publications/2016/central-asian-and-eastern-european-surveillance-of-antimicrobial-resistance.-annual-report-2016.</mixed-citation><mixed-citation xml:lang="en">Central Asian and European Surveillance of Antimicrobial Resistance (CAESAR). World Health Organization Regional Office for Europe. 2016. Available from: http://www.euro.who.int/en/health-topics/disease-prevention/antimicrobial-resistance/publications/2016/central-asian-and-eastern-european-surveillance-of-antimicrobial-resistance.-annual-report-2016.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez Martín D., Wrande M., Sandegren L., Zardán Gómez de la Torre T. Naked-eye detection of antibiotic resistance gene sul1 based on aggregation of magnetic nanoparticles and DNA amplification products. Biosensors and Bioelectronics: X. 2022; 12: 12100277. doi: 10.1016/j.biosx.2022.100277.</mixed-citation><mixed-citation xml:lang="en">Sánchez Martín D., Wrande M., Sandegren L., Zardán Gómez de la Torre T. Naked-eye detection of antibiotic resistance gene sul1 based on aggregation of magnetic nanoparticles and DNA amplification products. Biosensors and Bioelectronics: X. 2022; 12: 12100277. doi: 10.1016/j.biosx.2022.100277.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Leung E., Weil D. E., Raviglione M., Nakatani H. The WHO policy package to combat antimicrobial resistance. Bull World Health Organ. 2011; 89 (5): 390–392. doi: 10.2471/blt.11.088435.</mixed-citation><mixed-citation xml:lang="en">Leung E., Weil D. E., Raviglione M., Nakatani H. The WHO policy package to combat antimicrobial resistance. Bull World Health Organ. 2011; 89 (5): 390–392. doi: 10.2471/blt.11.088435.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Aslam B., Wang W., Arshad M. I., Khurshid M., Muzammil S., Rasool M. H. et al. Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist. 2018; 11: 1645–1658. doi: 10.2147/idr.s173867.</mixed-citation><mixed-citation xml:lang="en">Aslam B., Wang W., Arshad M. I., Khurshid M., Muzammil S., Rasool M. H. et al. Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist. 2018; 11: 1645–1658. doi: 10.2147/idr.s173867.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Coates A., Hu Y., Bax R., Page C. The future challenges facing the development of new antimicrobial drugs. Nat Rev Drug Discov. 2002; 1 (11): 895-910. doi: 10.1038/nrd940.</mixed-citation><mixed-citation xml:lang="en">Coates A., Hu Y., Bax R., Page C. The future challenges facing the development of new antimicrobial drugs. Nat Rev Drug Discov. 2002; 1 (11): 895-910. doi: 10.1038/nrd940.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">O’Connell K. M., Hodgkinson J. T., Sore H. F., Welch M., Salmond G. P., Spring D. R. Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials. Angewandte Chemie International Edition. 2013; 52 (41): 10706-10733. doi: 10.1002/anie.201209979.</mixed-citation><mixed-citation xml:lang="en">O’Connell K. M., Hodgkinson J. T., Sore H. F., Welch M., Salmond G. P., Spring D. R. Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials. Angewandte Chemie International Edition. 2013; 52 (41): 10706-10733. doi: 10.1002/anie.201209979.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Alekshun M., Levy S. Molecular mechanisms of antibactial multidrug resistance. Cell. 2007; 128 (6): 1037-1050. doi: 10.1016/j.cell.2007.03.004.</mixed-citation><mixed-citation xml:lang="en">Alekshun M., Levy S. Molecular mechanisms of antibactial multidrug resistance. Cell. 2007; 128 (6): 1037-1050. doi: 10.1016/j.cell.2007.03.004.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Al Marjani M. F., Mohammed R. K., Ahmed Z. O., Mohialden Y. M. Artificial intelligence and the silent pandemic of antimicrobial resistance: A comprehensive exploration. Journal La Multiapp. 2024; 5 (1): 25-37. doi: 10.37899/journallamultiapp.v5i1.952.</mixed-citation><mixed-citation xml:lang="en">Al Marjani M. F., Mohammed R. K., Ahmed Z. O., Mohialden Y. M. Artificial intelligence and the silent pandemic of antimicrobial resistance: A comprehensive exploration. Journal La Multiapp. 2024; 5 (1): 25-37. doi: 10.37899/journallamultiapp.v5i1.952.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Medernach R. L., Logan L. K. The growing threat of antibiotic resistance in children//Infect Dis Clin North Am. 2018; 32 (1): 1-17. doi: 10.1016/j.idc.2017.11.001.</mixed-citation><mixed-citation xml:lang="en">Medernach R. L., Logan L. K. The growing threat of antibiotic resistance in children//Infect Dis Clin North Am. 2018; 32 (1): 1-17. doi: 10.1016/j.idc.2017.11.001.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Partridge S. R., Kwong S. M., Firth N., Jensen S. O. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Rev. 2018; 31 (4): 1-61. doi: 10.1128/cmr.00088-17.</mixed-citation><mixed-citation xml:lang="en">Partridge S. R., Kwong S. M., Firth N., Jensen S. O. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Rev. 2018; 31 (4): 1-61. doi: 10.1128/cmr.00088-17.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Aminov R. I. Horizontal gene exchange in environmental microbiota. Front Microbiol. 2011; 2: 158. doi: 10.3389/fmicb.2011.00158.</mixed-citation><mixed-citation xml:lang="en">Aminov R. I. Horizontal gene exchange in environmental microbiota. Front Microbiol. 2011; 2: 158. doi: 10.3389/fmicb.2011.00158.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cisneros-Mayoral S., Graña-Miraglia L., Pérez-Morales D., Peña-Miller R., Fuentes-Hernández A. Evolutionary history and strength of selection determine the rate of antibiotic resistance adaptation. Mol Biol Evol. 2022; 39 (9): msac185. doi: 10.1093/molbev/msac185.</mixed-citation><mixed-citation xml:lang="en">Cisneros-Mayoral S., Graña-Miraglia L., Pérez-Morales D., Peña-Miller R., Fuentes-Hernández A. Evolutionary history and strength of selection determine the rate of antibiotic resistance adaptation. Mol Biol Evol. 2022; 39 (9): msac185. doi: 10.1093/molbev/msac185.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kummerer K. Resistance in the environment. J Antimicrob Chemother. 2004; 54 (2): 311-320. doi: 10.1093/jac/dkh325.</mixed-citation><mixed-citation xml:lang="en">Kummerer K. Resistance in the environment. J Antimicrob Chemother. 2004; 54 (2): 311-320. doi: 10.1093/jac/dkh325.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Acar J. F., Moulin G. Antimicrobial resistance: a complex issue. Rev Sci Tech. 2012; 31 (1): 23–31. doi: 10.20506/rst.31.1.2098.</mixed-citation><mixed-citation xml:lang="en">Acar J. F., Moulin G. Antimicrobial resistance: a complex issue. Rev Sci Tech. 2012; 31 (1): 23–31. doi: 10.20506/rst.31.1.2098.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Andrews J. M. Determination of minimum inhibitory concentrations. Journal of antimicrobial Chemotherapy. 2001; 48: 5-16. doi: 10.1093/jac/48.suppl_1.5.</mixed-citation><mixed-citation xml:lang="en">Andrews J. M. Determination of minimum inhibitory concentrations. Journal of antimicrobial Chemotherapy. 2001; 48: 5-16. doi: 10.1093/jac/48.suppl_1.5.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Puttaswamy S., Gupta S. K., Regunath H., Smith L. P., Sengupta S. A comprehensive review of the present and future antibiotic susceptibility testing (AST) systems. Archives of Clinical Microbiology. 2018; 9 (03): 83. doi: 10.4172/1989-8436.100083.</mixed-citation><mixed-citation xml:lang="en">Puttaswamy S., Gupta S. K., Regunath H., Smith L. P., Sengupta S. A comprehensive review of the present and future antibiotic susceptibility testing (AST) systems. Archives of Clinical Microbiology. 2018; 9 (03): 83. doi: 10.4172/1989-8436.100083.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">MacGowan A. P., Wise R. Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests. J Antimicrob Chemother. 2001; 48: 17-28. doi: 10.1093/jac/48.suppl_1.17.</mixed-citation><mixed-citation xml:lang="en">MacGowan A. P., Wise R. Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests. J Antimicrob Chemother. 2001; 48: 17-28. doi: 10.1093/jac/48.suppl_1.17.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Marschal M., Bachmaier J., Autenrieth I., Oberhettinger P., Willmann M., Peter S. et al. Evaluation of the accelerate Pheno™ system for fast identification and antimicrobial susceptibility testing from positive blood culture in gram-negative bloodstream infection. J Clin Microbiol. 2017; 55 (7): 2116-2126. doi: 10.1128/jcm.00181-17.</mixed-citation><mixed-citation xml:lang="en">Marschal M., Bachmaier J., Autenrieth I., Oberhettinger P., Willmann M., Peter S. et al. Evaluation of the accelerate Pheno™ system for fast identification and antimicrobial susceptibility testing from positive blood culture in gram-negative bloodstream infection. J Clin Microbiol. 2017; 55 (7): 2116-2126. doi: 10.1128/jcm.00181-17.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Riediker S., Diserens J. M., Stadler R. H. Analysis of β-lactam antibiotics in incurred raw milk by rapid test methods and liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Agric Food Chem. 2001; 49 (9): 4171–4176. doi: 10.1021/jf010057k.</mixed-citation><mixed-citation xml:lang="en">Riediker S., Diserens J. M., Stadler R. H. Analysis of β-lactam antibiotics in incurred raw milk by rapid test methods and liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Agric Food Chem. 2001; 49 (9): 4171–4176. doi: 10.1021/jf010057k.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Reynoso E. C., Laschi S., Palchetti I., Torres E. Advances in antimicrobial resistance monitoring using sensors and biosensors : a review. Chemosensors. 2021; 9 (8): 232. doi: 10.3390/chemosensors9080232.</mixed-citation><mixed-citation xml:lang="en">Reynoso E. C., Laschi S., Palchetti I., Torres E. Advances in antimicrobial resistance monitoring using sensors and biosensors : a review. Chemosensors. 2021; 9 (8): 232. doi: 10.3390/chemosensors9080232.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Guliy O. I., Zaitsev B. D., Borodina I. A. New approach for determination of antimicrobial susceptibility to antibiotics by an acoustic sensor. App Microbiol Biotechnol. 2020; 104 (3): 1283–1290. doi: 10.1007/s00253-019-10295-2.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Zaitsev B. D., Borodina I. A. New approach for determination of antimicrobial susceptibility to antibiotics by an acoustic sensor. App Microbiol Biotechnol. 2020; 104 (3): 1283–1290. doi: 10.1007/s00253-019-10295-2.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Guliy O. I., Zaitsev B. D., Borodina I. A. Electroacoustic biosensor systems for evaluating antibiotic action on microbial cells. Sensors (Basel). 2023; 23 (14): 6292. doi: 10.3390/s23146292.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Zaitsev B. D., Borodina I. A. Electroacoustic biosensor systems for evaluating antibiotic action on microbial cells. Sensors (Basel). 2023; 23 (14): 6292. doi: 10.3390/s23146292.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Vasala A., Hytönen V. P., Laitinen O. H. Modern tools for rapid diagnostics of antimicrobial resistance. Front Cell Infect Microbiol. 2020; 10: 308. doi: 10.3389/fcimb.2020.00308.</mixed-citation><mixed-citation xml:lang="en">Vasala A., Hytönen V. P., Laitinen O. H. Modern tools for rapid diagnostics of antimicrobial resistance. Front Cell Infect Microbiol. 2020; 10: 308. doi: 10.3389/fcimb.2020.00308.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pujol-Vila F., Villa R., Alvarez M. Nanomechanical sensors as a tool for bacteria detection and antibiotic susceptibility testing. Front Mech Eng. 2020; 6: 44. doi: 10.3389/fmech.2020.00044.</mixed-citation><mixed-citation xml:lang="en">Pujol-Vila F., Villa R., Alvarez M. Nanomechanical sensors as a tool for bacteria detection and antibiotic susceptibility testing. Front Mech Eng. 2020; 6: 44. doi: 10.3389/fmech.2020.00044.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Guliy O. I., Zaitsev B. D., Borodina I. A. Antibiotics and analytical methods used for their determination. In: Maurya P. K., Chandra P. Elsevier Ltd. editors. Nanobioanalytical approaches to medical diagnostics: Woodhead Publishing; 2022; Chapter 5; 143–177. ISBN 978-0-323-85147-3. doi: 10.1016/B978-0-323-85147-3.00004-9.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Zaitsev B. D., Borodina I. A. Antibiotics and analytical methods used for their determination. In: Maurya P. K., Chandra P. Elsevier Ltd. editors. Nanobioanalytical approaches to medical diagnostics: Woodhead Publishing; 2022; Chapter 5; 143–177. ISBN 978-0-323-85147-3. doi: 10.1016/B978-0-323-85147-3.00004-9.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Domingo-Roca R., Lasserre P., Riordan L., Macdonald A. R., Dobrea A., Duncan K. R. et al. Rapid assessment of antibiotic susceptibility using a fully 3D-printed impedance-based biosensor. Biosensors and Bioelectronics: X. 2023; 13: 100308. doi: 10.1016/j.biosx.2023.100308.</mixed-citation><mixed-citation xml:lang="en">Domingo-Roca R., Lasserre P., Riordan L., Macdonald A. R., Dobrea A., Duncan K. R. et al. Rapid assessment of antibiotic susceptibility using a fully 3D-printed impedance-based biosensor. Biosensors and Bioelectronics: X. 2023; 13: 100308. doi: 10.1016/j.biosx.2023.100308.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Qiu W., Nagl S. Automated miniaturized digital microfluidic antimicrobial susceptibility test using a chip-integrated optical oxygen sensor. ACS Sens. 2021; 6 (3): 1147–1156. doi: 10.1021/acssensors.0c02399.</mixed-citation><mixed-citation xml:lang="en">Qiu W., Nagl S. Automated miniaturized digital microfluidic antimicrobial susceptibility test using a chip-integrated optical oxygen sensor. ACS Sens. 2021; 6 (3): 1147–1156. doi: 10.1021/acssensors.0c02399.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Guliy O. I., Bunin V. D. Electrooptical analysis as sensing system for detection and diagnostics bacterial cells. In Chandra P., Pandey L. M. editors. Biointerface engineering: prospects in medical diagnostics and drug delivery: Springer, Singapore; 2020. Chapter 11. p. 233–254. ISBN 978-981-15-4789-8. doi: 10.1007/978-981-15-4790-4_11.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Bunin V. D. Electrooptical analysis as sensing system for detection and diagnostics bacterial cells. In Chandra P., Pandey L. M. editors. Biointerface engineering: prospects in medical diagnostics and drug delivery: Springer, Singapore; 2020. Chapter 11. p. 233–254. ISBN 978-981-15-4789-8. doi: 10.1007/978-981-15-4790-4_11.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Conteduca D., Brunetti G., Dell’Olio F., Armenise M. N., Krauss T. F., Ciminelli C. Monitoring of individual bacteria using electro-photonic traps. Biomed Opt Express. 2019; 10 (7): 3463-3471. doi: 10.1364/boe.10.003463.</mixed-citation><mixed-citation xml:lang="en">Conteduca D., Brunetti G., Dell’Olio F., Armenise M. N., Krauss T. F., Ciminelli C. Monitoring of individual bacteria using electro-photonic traps. Biomed Opt Express. 2019; 10 (7): 3463-3471. doi: 10.1364/boe.10.003463.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gfeller K. Y., Nugaeva N., Hegner M. Rapid biosensor for detection of antibiotic-selective growth of Escherichia coli. Appl Environ Microbiol. 2005; 71 (5): 2626-2631. doi: 10.1128/aem.71.5.2626-2631.2005.</mixed-citation><mixed-citation xml:lang="en">Gfeller K. Y., Nugaeva N., Hegner M. Rapid biosensor for detection of antibiotic-selective growth of Escherichia coli. Appl Environ Microbiol. 2005; 71 (5): 2626-2631. doi: 10.1128/aem.71.5.2626-2631.2005.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bennett I., Pyne A. L. B., McKendry R. A. Cantilever sensors for rapid optical antimicrobial sensitivity testing. ACS Sensors. 2020; 5 (10): 3133−3139. doi: 10.1021/acssensors.0c01216.</mixed-citation><mixed-citation xml:lang="en">Bennett I., Pyne A. L. B., McKendry R. A. Cantilever sensors for rapid optical antimicrobial sensitivity testing. ACS Sensors. 2020; 5 (10): 3133−3139. doi: 10.1021/acssensors.0c01216.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Longo G., Alonso-Sarduy L., Rio L. M., Bizzini A., Trampuz A., Notz J. et al. Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors. Nat Nanotechnol. 2013; 8 (7): 522-526. doi: 10.1038/nnano.2013.120.</mixed-citation><mixed-citation xml:lang="en">Longo G., Alonso-Sarduy L., Rio L. M., Bizzini A., Trampuz A., Notz J. et al. Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors. Nat Nanotechnol. 2013; 8 (7): 522-526. doi: 10.1038/nnano.2013.120.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Villalba M. I., Stupar P., Chomicki W., Bertacchi M., Dietler G. et al. Nanomotion detection method for testing antibiotic resistance and susceptibility of slow-growing bacteria. Small. 2017; 14 (4). doi: 10.1002/smll.201702671.</mixed-citation><mixed-citation xml:lang="en">Villalba M. I., Stupar P., Chomicki W., Bertacchi M., Dietler G. et al. Nanomotion detection method for testing antibiotic resistance and susceptibility of slow-growing bacteria. Small. 2017; 14 (4). doi: 10.1002/smll.201702671.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Etayash H., Khan M. F., Kaur K., Thundat T. Microfluidic cantilever detects bacteria and measures their susceptibility to antibiotics in small confined volumes. Nat Commun. 2016; 7 (1): 12947. doi: 10.1038/ncomms12947.</mixed-citation><mixed-citation xml:lang="en">Etayash H., Khan M. F., Kaur K., Thundat T. Microfluidic cantilever detects bacteria and measures their susceptibility to antibiotics in small confined volumes. Nat Commun. 2016; 7 (1): 12947. doi: 10.1038/ncomms12947.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Pitruzzello G., Thorpe S., Johnson S., Evans A., Gadelha H., Krauss T. F. Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli. Lab Chip 2019; 19 (8): 1417−1426. doi: 10.1039/c8lc01397g.</mixed-citation><mixed-citation xml:lang="en">Pitruzzello G., Thorpe S., Johnson S., Evans A., Gadelha H., Krauss T. F. Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli. Lab Chip 2019; 19 (8): 1417−1426. doi: 10.1039/c8lc01397g.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Boedicker J. Q., Li L., Kline T. R., Ismagilov R. F. Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip. 2008; 8 (8): 1265−1272. doi: 10.1039/b804911d.</mixed-citation><mixed-citation xml:lang="en">Boedicker J. Q., Li L., Kline T. R., Ismagilov R. F. Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip. 2008; 8 (8): 1265−1272. doi: 10.1039/b804911d.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Baltekin Ö., Boucharin A., Tano E., Andersson D. I., Elf J. Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging. Proc Natl Acad Sci USA. 2017; 114 (34): 9170-9175. doi: 10.1073/pnas.1708558114.</mixed-citation><mixed-citation xml:lang="en">Baltekin Ö., Boucharin A., Tano E., Andersson D. I., Elf J. Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging. Proc Natl Acad Sci USA. 2017; 114 (34): 9170-9175. doi: 10.1073/pnas.1708558114.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Choi J., Yoo J., Lee M., Kim E. G., Lee J. S., Lee S. et al. A rapid antimicrobial susceptibility test based on single-cell morphological analysis. Sci Transl Med. 2014; 6 (267); 267-174. doi: 10.1126/scitranslmed.3009650.</mixed-citation><mixed-citation xml:lang="en">Choi J., Yoo J., Lee M., Kim E. G., Lee J. S., Lee S. et al. A rapid antimicrobial susceptibility test based on single-cell morphological analysis. Sci Transl Med. 2014; 6 (267); 267-174. doi: 10.1126/scitranslmed.3009650.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Syal K., Iriya R., Yang Y., Yu H., Wang S., Haydel S. E. et al. Antimicrobial susceptibility test with plasmonic imaging and tracking of single bacterial motions on nanometer scale. ACS Nano. 2016; 10 (1): 845−852. doi: 10.1021/acsnano.5b05944.</mixed-citation><mixed-citation xml:lang="en">Syal K., Iriya R., Yang Y., Yu H., Wang S., Haydel S. E. et al. Antimicrobial susceptibility test with plasmonic imaging and tracking of single bacterial motions on nanometer scale. ACS Nano. 2016; 10 (1): 845−852. doi: 10.1021/acsnano.5b05944.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yu H., Jing W., Iriya R., Yang Y., Syal K., Mo M. et al. Phenotypic antimicrobial susceptibility testing with deep learning video microscopy. Anal Chem. 2018; 90 (10): 6314−6322. doi: 10.1021/acs.analchem.8b01128.</mixed-citation><mixed-citation xml:lang="en">Yu H., Jing W., Iriya R., Yang Y., Syal K., Mo M. et al. Phenotypic antimicrobial susceptibility testing with deep learning video microscopy. Anal Chem. 2018; 90 (10): 6314−6322. doi: 10.1021/acs.analchem.8b01128.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Stupar P., Opota O., Longo G., Prod’hom G., Dietler G., Greub G. et al. Nanomechanical sensor applied to blood culture pellets: a fast approach to determine the antibiotic susceptibility against agents of bloodstream infections. Clin Microbiol Infect. 2017; 23 (6): 400-405. doi: 10.1016/j.cmi.2016.12.028.</mixed-citation><mixed-citation xml:lang="en">Stupar P., Opota O., Longo G., Prod’hom G., Dietler G., Greub G. et al. Nanomechanical sensor applied to blood culture pellets: a fast approach to determine the antibiotic susceptibility against agents of bloodstream infections. Clin Microbiol Infect. 2017; 23 (6): 400-405. doi: 10.1016/j.cmi.2016.12.028.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Toosky M. N., Grunwald J. T., Pala D., Shen B., Zhao W., D'Agostini C. et al. A rapid, point-of-care antibiotic susceptibility test for urinary tract infections. J Med Microbiol. 2020; 69 (1): 52-62. doi: 10.1099/jmm.0.001119.</mixed-citation><mixed-citation xml:lang="en">Toosky M. N., Grunwald J. T., Pala D., Shen B., Zhao W., D'Agostini C. et al. A rapid, point-of-care antibiotic susceptibility test for urinary tract infections. J Med Microbiol. 2020; 69 (1): 52-62. doi: 10.1099/jmm.0.001119.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Aghayee S., Benadiba C., Notz J., Kasas S., Dietler G., Longo G. Combination of fluorescence microscopy and nanomotion detection to characterize bacteria. J Mol Recognit. 2013; 26 (11): 590-595. doi: 10.1002/jmr.2306.</mixed-citation><mixed-citation xml:lang="en">Aghayee S., Benadiba C., Notz J., Kasas S., Dietler G., Longo G. Combination of fluorescence microscopy and nanomotion detection to characterize bacteria. J Mol Recognit. 2013; 26 (11): 590-595. doi: 10.1002/jmr.2306.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Bermingham C. R., Murillo I., Payot A. D. J., Balram K. C., Kloucek M. B., Hanna S. et al. Imaging of sub-cellular fluctuations provides a rapid way to observe bacterial viability and response to antibiotics. BioRxiv. 2018: 460139. doi: 10.1101/460139.</mixed-citation><mixed-citation xml:lang="en">Bermingham C. R., Murillo I., Payot A. D. J., Balram K. C., Kloucek M. B., Hanna S. et al. Imaging of sub-cellular fluctuations provides a rapid way to observe bacterial viability and response to antibiotics. BioRxiv. 2018: 460139. doi: 10.1101/460139.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson W. L., France D. C., Rentz N. S., Cordell W. T., Walls F. L. Sensing bacterial vibrations and early response to antibiotics with phase noise of a resonant crystal. Sci Rep. 2017. 7 (1): 12138. doi: 10.1038/s41598-017-12063-6.</mixed-citation><mixed-citation xml:lang="en">Johnson W. L., France D. C., Rentz N. S., Cordell W. T., Walls F. L. Sensing bacterial vibrations and early response to antibiotics with phase noise of a resonant crystal. Sci Rep. 2017. 7 (1): 12138. doi: 10.1038/s41598-017-12063-6.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Jain M. C., Nadaraja A. V., Narang R., Zarifi M. H. Rapid and real-time monitoring of bacterial growth against antibiotics in solid growth medium using a contactless planar microwave resonator sensor. Sci Rep. 2021; 11 (1): 14775. doi: 10.1038/s41598-021-94139-y.</mixed-citation><mixed-citation xml:lang="en">Jain M. C., Nadaraja A. V., Narang R., Zarifi M. H. Rapid and real-time monitoring of bacterial growth against antibiotics in solid growth medium using a contactless planar microwave resonator sensor. Sci Rep. 2021; 11 (1): 14775. doi: 10.1038/s41598-021-94139-y.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Narang R., Mohammadi S., Ashani M. M., Sadabadi H., Hejazi H., Hossein Z. M. Sensitive, real-time and non-Intrusive detection of concentration and growth of pathogenic bacteria using microfuidic-microwave ring resonator biosensor. Sci Rep. 2018; 8 (1): 15807. doi: 10.1038/s41598-018-34001-w.</mixed-citation><mixed-citation xml:lang="en">Narang R., Mohammadi S., Ashani M. M., Sadabadi H., Hejazi H., Hossein Z. M. Sensitive, real-time and non-Intrusive detection of concentration and growth of pathogenic bacteria using microfuidic-microwave ring resonator biosensor. Sci Rep. 2018; 8 (1): 15807. doi: 10.1038/s41598-018-34001-w.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Гулий О. И., Зайцев Б. Д., Караваева О. А., Ловцова Л. Г., Мехта С. К., Бородина И. А. Экспресс-анализ чувствительности бактерий к бета-лактамным антибиотикам с помощью резонатора с поперечным электрическим полем. Антибиотики и химиотер. 2019; 64 (1-2): 3-8. doi: 10.24411/0235W2990W2019W10001.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Zaitsev B. D., Karavaeva O. A., Lovtsova L. G., Mehta S. K., Borodina I. A. STAT analysis of the sensitivity of bacteria to beta-lactam antibiotics using a resonator with a transverse electric field. Antibiot Khimioter = Antibiotics and Chemotherapy. 2019; 64 (1-2): 3-8. doi: 10.24411/0235W2990W2019W10001. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Гулий О. И., Зайцев Б. Д., Алсовэйди А. К.М., Караваева О. А., Семёнов А. П., Бородина И. А. Экспресс-анализ воздействия аминогликозидов на бактерии с помощью сенсорной системы на основе пьезоэлектрического резонатора с поперечным электрическим полем. Антибиотики и химиотер. 2023; 68 (1–2): 4–10. doi: 10.37489/0235-2990-2023-68-1-2-4-10.</mixed-citation><mixed-citation xml:lang="en">Guliy О. I., Zaitsev B. D., Alsowaidi A. К. М., Karavaeva О. А., Semyonov A. P., Borodina I. A. Rapid analysis of the effect of aminoglycosides on bacteria by using a sensor system based on a piezoelectric resonator with a lateral electric field. Antibiotiki i Khimioter = Antibiotics and Chemotherapy. 2023; 68: 1–2: 4–10. doi: 10.37489/0235-2990-2023-68-1-2-4-10. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Dina N. E., Tahir M. A., Bajwa S. Z., Amin I., Valev V. K., Zhang L. SERS-based antibiotic susceptibility testing: Towards point-of-care clinical diagnosis. Biosens Bioelectron. 2023; 1: 219: 114843. doi: 10.1016/j.bios.2022.114843.</mixed-citation><mixed-citation xml:lang="en">Dina N. E., Tahir M. A., Bajwa S. Z., Amin I., Valev V. K., Zhang L. SERS-based antibiotic susceptibility testing: Towards point-of-care clinical diagnosis. Biosens Bioelectron. 2023; 1: 219: 114843. doi: 10.1016/j.bios.2022.114843.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Романова Ю. М., Гинцбург А. Л. Бактериальные биоплёнки как естественная форма существования бактерий в окружающей среде и организме хозяина. Журнал микробиологии, эпидемиологии и иммунобиологии. 2011; 3: 99-109.</mixed-citation><mixed-citation xml:lang="en">Romanova Jyu. M., Gintsburg A. L. Bakterial'nye bioplenki kak estestvennaya forma sushchestvovaniya bakterij v okruzhajyushchej srede i organizme khozyaina. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2011; 3: 99-109. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Dincer S., Masume Uslu F., Delik A. Antibiotic resistance in biofilm. Bacterial Biofilms. doi: 10.5772/intechopen.92388.</mixed-citation><mixed-citation xml:lang="en">Dincer S., Masume Uslu F., Delik A. Antibiotic resistance in biofilm. Bacterial Biofilms. doi: 10.5772/intechopen.92388.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Bagge N., Ciofu O., Skovgaard L. T., Høiby N. Rapid development in vitro and in vivo of resistance to ceftazidime in biofilmgrowing Pseudomonas aeruginosa due to chromosomal betalactamase. APMIS. 2000; 108: 589–600. doi: 10.1034/j.1600-0463.2000.d01-102.x.</mixed-citation><mixed-citation xml:lang="en">Bagge N., Ciofu O., Skovgaard L. T., Høiby N. Rapid development in vitro and in vivo of resistance to ceftazidime in biofilmgrowing Pseudomonas aeruginosa due to chromosomal betalactamase. APMIS. 2000; 108: 589–600. doi: 10.1034/j.1600-0463.2000.d01-102.x.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Thieme L., Hartung A., Tramm K., Klinger-Strobel M., Jandt K. D., Makarewicz O. et al. MBEC Versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology. Biological Procedures Online. 2019; 21 (1): 18. doi: 10.1186/s12575-019-0106-0.</mixed-citation><mixed-citation xml:lang="en">Thieme L., Hartung A., Tramm K., Klinger-Strobel M., Jandt K. D., Makarewicz O. et al. MBEC Versus MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology. Biological Procedures Online. 2019; 21 (1): 18. doi: 10.1186/s12575-019-0106-0.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Rafaque Z., Abid N., Liaquat N., Afridi P., Siddique S., Masood S. In-vitro investigation of antibiotics efficacy against uropathogenic Escherichia coli biofilms and antibiotic induced biofilm formation at subminimum inhibitory concentration of ciprofloxacin Infect Drug Resist. 2020; 13: 2801–2810. doi: 10.2147/idr.s258355.</mixed-citation><mixed-citation xml:lang="en">Rafaque Z., Abid N., Liaquat N., Afridi P., Siddique S., Masood S. In-vitro investigation of antibiotics efficacy against uropathogenic Escherichia coli biofilms and antibiotic induced biofilm formation at subminimum inhibitory concentration of ciprofloxacin Infect Drug Resist. 2020; 13: 2801–2810. doi: 10.2147/idr.s258355.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Macia M. D., Rojo-Molinero E., Oliver A. Antimicrobial susceptibility testing in biofilm-growing bacteria. Clin Microbiol Infect. 2014; 20 (10): 981-990. doi: 10.1111/1469-0691.12651.</mixed-citation><mixed-citation xml:lang="en">Macia M. D., Rojo-Molinero E., Oliver A. Antimicrobial susceptibility testing in biofilm-growing bacteria. Clin Microbiol Infect. 2014; 20 (10): 981-990. doi: 10.1111/1469-0691.12651.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Dall G. F., Tsang S. J., Gwynne P. J., MacKenzie S. P., Simpson A., Breusch S. J. et al. Unexpected synergistic and antagonistic antibiotic activity against Staphylococcus biofilms. J Antimicrob Chemother. 2018; 73 (7): 1830–1840. doi: 10.1093/jac/dky087.</mixed-citation><mixed-citation xml:lang="en">Dall G. F., Tsang S. J., Gwynne P. J., MacKenzie S. P., Simpson A., Breusch S. J. et al. Unexpected synergistic and antagonistic antibiotic activity against Staphylococcus biofilms. J Antimicrob Chemother. 2018; 73 (7): 1830–1840. doi: 10.1093/jac/dky087.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Cruz C. D., Shah S., Tammela P. Defining conditions for biofilm inhibition and eradication assays for gram-positive clinical reference strains. BMC Microbiology. 2018; 18 (1): 173. doi: 10.1186/s12866-018-1321-6.</mixed-citation><mixed-citation xml:lang="en">Cruz C. D., Shah S., Tammela P. Defining conditions for biofilm inhibition and eradication assays for gram-positive clinical reference strains. BMC Microbiology. 2018; 18 (1): 173. doi: 10.1186/s12866-018-1321-6.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Magana M., Sereti C., Ioannidis A., Mitchell C. A., Ball A. R., Magiorkinis E. et al. Options and limitations in clinical investigation of bacterial biofilms. Clin Microbiol Rev. 2018; 31 (3): e00084-16. doi: 10.1128/CMR.00084-16.</mixed-citation><mixed-citation xml:lang="en">Magana M., Sereti C., Ioannidis A., Mitchell C. A., Ball A. R., Magiorkinis E. et al. Options and limitations in clinical investigation of bacterial biofilms. Clin Microbiol Rev. 2018; 31 (3): e00084-16. doi: 10.1128/CMR.00084-16.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Kim Y. W., Meyer M. T., Berkovich A., Subramanian S., Iliadis A. A., Bentley W. E. et al. A surface acoustic wave biofilm sensor integrated with a treatment method based on the bioelectric effect. Sensors and Actuators A: Physical. 2016; 238: 140–149. doi: 10.1016/j.sna.2015.12.001.</mixed-citation><mixed-citation xml:lang="en">Kim Y. W., Meyer M. T., Berkovich A., Subramanian S., Iliadis A. A., Bentley W. E. et al. A surface acoustic wave biofilm sensor integrated with a treatment method based on the bioelectric effect. Sensors and Actuators A: Physical. 2016; 238: 140–149. doi: 10.1016/j.sna.2015.12.001.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Piasecki T., Guła G., Waszczuk K., Drulis-Kawa Z., Gotszalk T. Quartz tuning fork as in-situ sensor of bacterial biofilm. Procedia Engineering. 2014; 87: 369–372. doi: 10.1016/j.proeng.2014.11.740.</mixed-citation><mixed-citation xml:lang="en">Piasecki T., Guła G., Waszczuk K., Drulis-Kawa Z., Gotszalk T. Quartz tuning fork as in-situ sensor of bacterial biofilm. Procedia Engineering. 2014; 87: 369–372. doi: 10.1016/j.proeng.2014.11.740.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Yeor‑Davidi E., Zverzhinetsky M., Krivitsky V., Patolsky F. Real‑time monitoring of bacterial biofilms metabolic activity by a redox‑reactive nano-sensors array. J Nanobiotechnol. 2020; 18 (1): 81. doi: 10.1186/s12951-020-00637-y.</mixed-citation><mixed-citation xml:lang="en">Yeor‑Davidi E., Zverzhinetsky M., Krivitsky V., Patolsky F. Real‑time monitoring of bacterial biofilms metabolic activity by a redox‑reactive nano-sensors array. J Nanobiotechnol. 2020; 18 (1): 81. doi: 10.1186/s12951-020-00637-y.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Guliy O. I., Evstigneeva S. S., Shirokov A. A., Bunin V. D. Sensor system for analysis of biofilm sensitivity to ampicillin. Appl Microbiol Biotechnol. 2024; 108: 172. doi: 10.1007/s00253-023-12831-7.</mixed-citation><mixed-citation xml:lang="en">Guliy O. I., Evstigneeva S. S., Shirokov A. A., Bunin V. D. Sensor system for analysis of biofilm sensitivity to ampicillin. Appl Microbiol Biotechnol. 2024; 108: 172. doi: 10.1007/s00253-023-12831-7.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Blanco-Cabra N., López-Martíne M. J., Arévalo-Jaimes B. V., Martin-Gómez M. T., Samitier J., Torrents E. A new BiofilmChip device for testing biofilm formation and antibiotic susceptibility. NPJ Biofilms Microbiomes. 2021; 7 (1): 62. doi: 10.1038/s41522-021-00236-1.</mixed-citation><mixed-citation xml:lang="en">Blanco-Cabra N., López-Martíne M. J., Arévalo-Jaimes B. V., Martin-Gómez M. T., Samitier J., Torrents E. A new BiofilmChip device for testing biofilm formation and antibiotic susceptibility. NPJ Biofilms Microbiomes. 2021; 7 (1): 62. doi: 10.1038/s41522-021-00236-1.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Catalano A., Iacopetta D., Ceramella J., Scumaci D., Giuzio F., Saturnino C. et al. Multidrug resistance (MDR): a widespread phenomenon in pharmacological therapies. Molecules. 2022; 27 (3): 616. doi: 10.3390/molecules27030616.</mixed-citation><mixed-citation xml:lang="en">Catalano A., Iacopetta D., Ceramella J., Scumaci D., Giuzio F., Saturnino C. et al. Multidrug resistance (MDR): a widespread phenomenon in pharmacological therapies. Molecules. 2022; 27 (3): 616. doi: 10.3390/molecules27030616.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Ding P., Gao Y., Wang J., Xiang H., Zhang C., Wang L. et al Progress and challenges of multidrug resistance proteins in diseases. Am J Cancer Res. 2022; 12 (10): 4483–4501.</mixed-citation><mixed-citation xml:lang="en">Ding P., Gao Y., Wang J., Xiang H., Zhang C., Wang L. et al Progress and challenges of multidrug resistance proteins in diseases. Am J Cancer Res. 2022; 12 (10): 4483–4501.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Antimicrobial resistance: a manual for developing national action plans. Publications of the World Health Organization: 2016. 2016. ISBN 978-92-4-154953-0. Available from: web site (www.who.int).</mixed-citation><mixed-citation xml:lang="en">Antimicrobial resistance: a manual for developing national action plans. Publications of the World Health Organization: 2016. 2016. ISBN 978-92-4-154953-0. Available from: web site (www.who.int).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
