antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2025-70-1-2-100-112UVGNHEantibiotics-1228Research ArticleОБЗОРЫREVIEWSК проблеме безопасности вакцинопрофилактики COVID-19 у ревматологических пациентов: итоги и перспективыOn the Safety of COVID-19 Vaccine Prophylaxis in Rheumato- logical Patients: Results and Prospectshttps://orcid.org/0000-0001-7091-2054БеловБ. С.BelovB. S.

Борис Сергеевич Белов, д. м. н., заведующий лабораторией

лаборатория коморбидных инфекций и вакцинопрофилактики

Москва

ResearcherID: ABD-2219-2020; Scopus Author ID: 7004592537

Boris S. Belov, D. Sc. in Medicine, Head of the Laboratory

Laboratory of Comorbid Infections and Vaccine Prevention

Moscow

ResearcherID: ABD-2219-2020; Scopus Author ID: 7004592537

belovbor@yandex.ruhttps://orcid.org/0000-0003-4327-6720МуравьеваН. В.MuravyevaN. V.

Наталья Валерьевна Муравьева, к. м. н., старший научный сотрудник

лаборатория коморбидных инфекций и вакцинопрофилактики

Москва

ResearcherID: AAF-4853-2021; Scopus Author ID: 57210263706

Natalia V. Muravyeva, Ph. D. in Medicine, Senior Researcher

Laboratory of Comorbid Infections and Vaccine Prevention

Moscow

ResearcherID: AAF-4853-2021; Scopus Author ID: 57210263706

https://orcid.org/0009-0008-4988-9935ПерепечаеваО. Б.PerepechaevaO. B.

Оксана Борисовна Перепечаева, клинический ординатор

Москва

Oksana B. Perepechaeva, Clinical Resident

Moscow

ФГБНУ НИИ ревматологии им. В. А. НасоновойРоссияV. A. Nasonova Research Institute of RheumatologyRussian Federation202509062025701-2100112Copyright © Белов Б.С., Муравьева Н.В., Перепечаева О.Б., 20252025Белов Б.С., Муравьева Н.В., Перепечаева О.Б.Belov B.S., Muravyeva N.V., Perepechaeva O.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1228

   Пандемия коронавирусной болезни 2019 (novel coronavirus disease, COVID-19) привлекла внимание медицинского сообщества к новым клиническим и фундаментальным проблемам иммунопатологии заболеваний человека. Несмотря на снятие режима международной чрезвычайной ситуации и объявление о завершении пандемии COVID-19, Всемирная организация здравоохранения подчеркнула необходимость дальнейшей поддержки научных исследований по совершенствованию вакцин, способствующих снижению интенсивности распространения вируса и имеющих перспективы широкого применения. В настоящем обзоре представлены результаты исследований последних лет по проблеме безопасности вакцинации против COVID-19 у больных ревматическими заболеваниями (РЗ). В целом частота обострения РЗ после вакцинации против COVID-19 представляется достаточно низкой (5–10 %) и не имеет статистически значимых ассоциаций с конкретной вакциной или проводимой противоревматической терапией. Обозначены перспективы применения моноклональных антител с целью доконтактной профилактики COVID-19 у больных РЗ.

   The coronavirus disease pandemic 2019 (novel coronavirus disease, COVID-19) has attracted the attention of the medical community to new clinical and fundamental problems of human disease immunopathology. Despite the lifting of the international emergency regime and the announcement of the end of the COVID-19 pandemic, the World Health Organization (WHO) stressed the need to continue supporting scientific research to improve vaccines that help reduce the spread of the virus and have prospects for widespread use. This review presents the results of recent studies on the safety of vaccination against COVID-19 in patients with rheumatic diseases (RD). In general, the frequency of exacerbation of RD after vaccination against COVID-19 seems to be quite low (5–10 %) and has no statistically significant associations with a specific vaccine or antirheumatic therapy. The prospects of using monoclonal antibodies for the purpose of pre-exposure prophylaxis of COVID-19 in patients with RD are outlined.

COVID-19ревматические заболеваниявакцинациянежелательные явлениябезопасностьмоноклональные антителадоконтактная профилактикаCOVID-19rheumatic diseasesvaccinationadverse eventssafetymonoclonal antibodiespre-exposure prophylaxisСтатья подготовлена в рамках научно-исследовательской работы ФГБНУ «Научно-исследовательский институт ревматологии им. В. А. Насоновой», № государственного задания РК 125020301268-4. Исследование не имело спонсорской поддержкиThe article was prepared as part of the research work of the V. A. Nasonova Scientific Research Institute of Rheumatology, State assignment No. of the RK 125020301268-4. 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The authors declare that there are no conflicts of interest present.