antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2025-70-5-6-72-80XSDNPTantibiotics-1263Research ArticleОБЗОРЫREVIEWSИнфекционный эндокардит с отрицательной гемокультурой: современные аспектыBlood Culture-Negative Endocarditishttps://orcid.org/0000-0001-7091-2054БеловБ. С.BelovB. S.

Борис Сергеевич Белов, д. м. н., заведующий лабораторией

лаборатория коморбидных инфекций и вакцинопрофилактики

Москва

Researcher ID: ABD-2219-2020; Scopus Author ID: 7004592537

Boris S. Belov, D.Sc. in Medicine, Head of the Laboratory

Laboratory of Comorbid Infections and Vaccine Prevention

Moscow

Researcher ID: ABD-2219-2020; Scopus Author ID: 7004592537

belovbor@yandex.ruhttps://orcid.org/0000-0001-9933-5350ТарасоваГ. М.TarasovaG. M.

Галина Михайловна Тарасова, к. м. н., старший научный сотрудник

лаборатория тромбовоспаления

Москва

Researcher ID: AAF-3477-2021; Scopus Author ID: 7005497817

Galina M. Tarasova, Ph.D. in Medicine, Senior Researcher

Laboratory of Thromboinflammation

Moscow

Researcher ID: AAF-3477-2021; Scopus Author ID: 7005497817

https://orcid.org/0000-0003-4327-6720МуравьеваН. В.MuravyevaN. V.

Наталья Валерьевна Муравьева, к. м. н., старший научный сотрудник

лаборатория коморбидных инфекций и вакцинопрофилактики

Москва

ResearcherID: AAF-4853-2021; Scopus Author ID: 57210263706

Natalia V. Muravyeva, Ph.D. in Medicine, Senior Researcher

Laboratory of Comorbid Infections and Vaccine Prevention

Moscow

ResearcherID: AAF-4853-2021; Scopus Author ID: 57210263706

ФГБНУ «Научно-исследовательский институт ревматологии им. В. А. НасоновойРоссияV. A. Nasonova Research Institute of RheumatologyRussian Federation202515032025705-67280Copyright © Белов Б.С., Тарасова Г.М., Муравьева Н.В., 20252025Белов Б.С., Тарасова Г.М., Муравьева Н.В.Belov B.S., Tarasova G.M., Muravyeva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1263

   Инфекционный эндокардит с отрицательной гемокультурой (ИЭОГ) представляет собой важную клиническую проблему, поскольку идентификация возбудителя и его чувствительность к антиинфекционным препаратам имеет решающее значение для обеспечения оптимальной терапии данного заболевания. Наиболее частыми причинами ИЭОГ являются назначение антибиотиков до взятия крови на исследование или инфицирование микроорганизмами, требующими для их идентификации особых методик и специального оборудования. Признавая чрезвычайную актуальность данной проблемы, Американская кардиологическая ассоциация опубликовала специальное заявление, ведущим побудительным моментом к разработке которого послужил ряд внедрённых в практику за последние годы ключевых достижений в области молекулярной диагностики, а также разнообразных методик визуализации, способствующих выявлению кардиальных и внесердечных очагов поражения. В настоящей статье прокомментированы основные положения указанного документа.

   Blood culture–negative endocarditis (BCNE) is an important clinical problem, since the identification of the pathogen and its sensitivity to anti-infective drugs is crucial to ensure optimal treatment of this disease. The most common causes of BCNE are the administration of antibiotics before blood culture for examination or infection with microorganisms that require special techniques and special equipment to identify them. Recognizing the extreme urgency of this problem, the American Heart Association issued a special statement, with a number of key achievements in the field of molecular diagnostics introduced into practice in recent years, as well as a variety of imaging techniques that help identify cardiac and extracardiac lesions as the leading source of motivation. This article comments on the main provisions of this document.

инфекционный эндокардит с отрицательной гемокультуройэпидемиологические факторымолекулярно-биологическая диагностикаметоды визуализацииантибактериальная терапияBlood culture-negative endocarditisepidemiological factorsmolecular biological diagnosticsimaging methodsantibacterial therapyСтатья подготовлена в рамках научно-исследовательской работы ФГБНУ «Научно-исследовательский институт ревматологии им. В. А. Насоновой», № государственного задания РК 125020301268-4. Исследование не имело спонсорской поддержкиThe article was prepared as part of the research work of the Federal State Budgetary Scientific Institution “V. A. Nasonova Research Institute of Rheumatology”, No. of the state task of the Republic of Kazakhstan 125020301268-4. The study did not have sponsorshipReferencesТюрин В. П. Инфекционные эндокардиты. Москва: ГЭОТАР-Медиа; 2012; 368. [Tyurin V. P. Infektsionnye endokardityInfective endocarditis]. Moscow: GEOTAR-Media: 2012. 368. (in Russian)Шевченко Ю. Л. 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The authors declare that there are no conflicts of interest present.