antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2025-70-7-8-74-91WMUGXTantibiotics-1273Research ArticleОБЗОРЫREVIEWSАльтернативный терапевтический потенциал антибиотиков, ингибирующих бактериальную трансляцию, как регуляторов митохондриальной дисфункцииAlternative Therapeutic Potential of Antibiotics Inhibiting Bacterial Translation as Regulators of Mitochondrial Dysfunctionhttps://orcid.org/0000-0003-4799-1318КисильО. В.KisilO. V.

Ольга Валерьевна Кисиль — к. х. н., ученый секретарь.

Москва

Olga V. Kisil — Ph. D. in Chemistry, Scientific Secretary.

Moscow

olvv@mail.ruhttps://orcid.org/0000-0002-7432-1574ЗвереваМ. Э.ZverevaM. I.

Мария Эмильевна Зверева — д. х. н., профессор кафедры химии природных соединений химического факультета МГУ им. М. В. Ломоносова.

Москва

Maria I. Zvereva — D. Sc. in Chemistry, Professor, Department of Chemistry of Natural Compounds, Faculty of Chemistry.

Moscow

https://orcid.org/0000-0002-2598-913XОлсуфьеваЕ. Н.OlsufyevaE. I.

Евгения Николаевна Олсуфьева — д. х. н., профессор, главный научный сотрудник.

Москва

Evgeniya N. Olsufyeva — D. Sc. in Chemistry, Professor, Chief Researcher. Gause Institute of New Antibiotics

Moscow

ФГБНУ «Научно-исследовательский институт по изысканию новых антибиотиков им. Г.Ф. Гаузе»РоссияGause Institute of New AntibioticsRussian FederationМосковский государственный университет им. М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation202525072025707-87491Copyright © Кисиль О.В., Зверева М.Э., Олсуфьева Е.Н., 20252025Кисиль О.В., Зверева М.Э., Олсуфьева Е.Н.Kisil O.V., Zvereva M.I., Olsufyeva E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/1273

Антибиотики, эволюционно появившиеся как химическое оружие одних бактерий против других, в первую очередь известны своим микробицидным и/или бактериостатическим действием, однако они также обладают многочисленными плейотропными эффектами: антиамилоиденными, противовоспалительными, антиоксидантными и антиапоптотическими. В обзоре рассматриваются антибактериальные препараты, по механизму действия, ингибирующие трансляцию, в первую очередь тетрациклины, в контексте их неантибиотического биологического аспекта, а именно возможности поддерживающей терапии при нейродегенеративных заболеваниях, а также их антимитохондриальное действие и опосредованный им эффект отмены старения.

Antibiotics, which evolved as a chemical weapon of some bacteria against others, are primarily known for their microbicidal and/or bacteriostatic effects; however, they also have numerous pleiotropic effects: anti-amyloid, anti-inflammatory, antioxidant, and anti-apoptotic. This review considers antibiotics with a translation-inhibiting mechanism of action, primarily tetracyclines, in the context of their non-antibiotic biological aspect, namely, the possibilities of supportive therapy for neurodegenerative diseases, as well as their antimitochondrial action and the mediated effect of aging cancellation.

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The authors declare that there are no conflicts of interest present.