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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/0235-2990-2026-71-1-2-42-47</article-id><article-id custom-type="edn" pub-id-type="custom">QWGCGF</article-id><article-id custom-type="elpub" pub-id-type="custom">antibiotics-1328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>Методы предоперационной морфологической верификации меланомы кожи. Современные подходы и перспективы развития</article-title><trans-title-group xml:lang="en"><trans-title>Methods of Preoperative Morphological Verification of Skin Melanoma. Current Approaches and Development Prospects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6284-4140</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляков</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поляков Илья Алексеевич — врач онколог онкологического отделения № 1 ЦАОП</p><p>Москва</p></bio><bio xml:lang="en"><p>Ilya A. Polyakov — Oncologist at the Oncology Department No. 1</p><p>Moscow</p></bio><email xlink:type="simple">zebra19988@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2316-7482</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Неретин</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Neretin</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Неретин Евгений Юрьевич — д. м. н., врач-онколог, старший научный сотрудник</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgeny Yu. Neretin — D. Sc. in Medicine, Oncologist, Senior Researcher</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4460-9136</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Titov</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Титов Константин Сергеевич — д. м. н., профессор, врачонколог, хирург, ведущий научный сотрудник</p><p>Москва</p></bio><bio xml:lang="en"><p>Konstantin S. Titov — D. Sc. in Medicine, Professor, Oncologist, Surgeon, Leading Researcher</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0706-9575</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколов</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolov</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколов Николай Юрьевич — к. м. н., врач-онколог, старший научный сотрудник, заведующий онкологическим отделением противоопухолевой лекарственной терапии № 15</p><p>Москва</p></bio><bio xml:lang="en"><p>Nikolay Yu. Sokolov — Ph. D. in Medicine, Oncologist, Senior Researcher</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5366-1281</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедев Сергей Сергеевич — д. м. н., врач-онколог, хирург, ведущий научный сотрудник, заместитель главного врача по онкологии; профессор кафедры хирургии</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey S. Lebedev — D. Sc. in Medicine, Oncologist, Surgeon, Deputy Chief Physician for Oncology, Leading Researcher; Professor at the Department of Surgery</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0677-2338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулушев</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulushev</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кулушев Вадим Маратович — к. м. н., врач-онколог, колопроктолог, старший научный сотрудник, заведующий онкоколопроктологическим отделением № 74  </p><p>Москва</p></bio><bio xml:lang="en"><p>Vadim M. Kulushev — Ph. D. in Medicine, Oncologist, Proctologist, Head of the Oncocoloproctology Department No. 74, Senior Researcher </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2715-3933</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якушева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakusheva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Якушева Татьяна Александровна — врач-онколог, заведующая онкологическим отделением № 1 ЦАОП</p><p>Москва</p></bio><bio xml:lang="en"><p>Tatyana A. Yakusheva — Oncologist, Head of the Oncology Department No. 1</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Московский многопрофильный научно-клинический центр имени Сергея Петровича Боткина»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Botkin Multidisciplinary Scientific-Clinical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Московский многопрофильный научно-клинический центр имени Сергея Петровича Боткина»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здраво-охранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Botkin Multidisciplinary Scientific-Clinical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Московский многопрофильный научно-клинический центр имени Сергея Петровича Боткина»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здраво-охранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Botkin Multidisciplinary Scientific-Clinical Center; Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>25</day><month>02</month><year>2026</year></pub-date><volume>71</volume><issue>1-2</issue><fpage>42</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Поляков И.А., Неретин Е.Ю., Титов К.С., Соколов Н.Ю., Лебедев С.С., Кулушев В.М., Якушева Т.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Поляков И.А., Неретин Е.Ю., Титов К.С., Соколов Н.Ю., Лебедев С.С., Кулушев В.М., Якушева Т.А.</copyright-holder><copyright-holder xml:lang="en">Polyakov I.A., Neretin E.Y., Titov K.S., Sokolov N.Y., Lebedev S.S., Kulushev V.M., Yakusheva T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/1328">https://www.antibiotics-chemotherapy.ru/jour/article/view/1328</self-uri><abstract><p>Кожная меланома (КМ) — серьёзная проблема современной онкологии как в России, так и во многих странах мира. По данным Мирового ракового регистра, в 2022 г. было зарегистрировано 331 722 новых случаев кожной меланомы, из которых 4% пришлись на пациентов из Российской Федерации. На кожную меланому приходится 70,3% смертей среди пациентов со злокачественными опухолями кожи. За последнее десятилетие наблюдается ежегодный рост числа случаев меланомы на 3–4%, особенно среди людей со светлым фототипом кожи. Морфологическая верификация первичной кожной меланомы (КМ) является критически важным этапом в диагностике и определении адекватной тактики лечения этого заболевания. Гистологическая и цитологическая верификация необходимы для точного подтверждения диагноза и определения прогностических факторов заболевания. Цель обзора — анализ диагностической ценности различных методов первичной верификации КМ, а также дальнейших перспектив совершенствования диагностики.</p></abstract><trans-abstract xml:lang="en"><p>Cutaneous melanoma (CM) is a serious problem of modern oncology, both in Russia and in many countries of the world. According to the Global Canсer Registry, 331,722 new cases of cutaneous melanoma were reported in 2022, of which 4% were patients from the Russian Federation. Skin melanoma accounts for 70.3% of deaths in patients with malignant skin tumors. Over the past decade, there has been an annual increase in melanoma cases by 3–4%, especially among people with light skin phototypes. Morphological verification of primary cutaneous melanoma (CM) is a critically important stage in the diagnosis and determination of adequate treatment tactics for this disease. Histological and cytological verification are necessary methods for accurate confirmation of the diagnosis and determination of prognostic factors for the disease. This review aims to analyze the diagnostic value of various methods of primary verification of CM, as well as further prospects for improving diagnostics.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>меланома кожи</kwd><kwd>морфологическая верификация</kwd><kwd>биопсия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cutaneous melanoma</kwd><kwd>oncology</kwd><kwd>diagnosis</kwd><kwd>biopsy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GLOBOCAN. International Agency for Research on Cancer. World Health Organization 2022.</mixed-citation><mixed-citation xml:lang="en">GLOBOCAN. International Agency for Research on Cancer. 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