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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24411/0235-2990-2019-10053</article-id><article-id custom-type="elpub" pub-id-type="custom">antibiotics-179</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>Менингит: трудности диагностики, клиника и лечение</article-title><trans-title-group xml:lang="en"><trans-title>Meningitis: Difficulties in Diagnosis, Clinical Characteristics, and Treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>V. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sychev</surname><given-names>D. А.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilieva</surname><given-names>E. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серёдкин</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Seredkin</surname><given-names>E. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НУЗ Научный клинический центр ОАО «Российские железные дороги»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Clinical Center of Jsc Russian Railways</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>08</day><month>05</month><year>2020</year></pub-date><volume>64</volume><issue>9-10</issue><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соколова В.И., Сычёв Д.А., Васильева Е.И., Серёдкин Е.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Соколова В.И., Сычёв Д.А., Васильева Е.И., Серёдкин Е.А.</copyright-holder><copyright-holder xml:lang="en">Sokolova V.I., Sychev D.А., Vasilieva E.I., Seredkin E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/179">https://www.antibiotics-chemotherapy.ru/jour/article/view/179</self-uri><abstract><p>В статье представлен клинический пример трудности диагностики менингита у больной с невыраженным менингеальным симптомокомплексом. Среди разнообразных диагностических и лечебных подходов, есть ключевые методы исследовании, которые позволили выявить природу инфекционного процесса, поставить диагноз вторичного отогенного бактериального пневмококкового менингита и провести этиотропную антибактериальную терапию. Анализ данного клинического случая показал, что тяжесть иифекционно-воспалительного процесса определялась не только возбудителем Streptococcus pneumoniae, но и имеющимся вторичным иммунодефицитным состоянием (сахарный диабет, протезы и др.). В связи с чем, существенное внимание уделялось не только коррекции гликемии, антимикробной, но и антиоксидантной терапии, что и обеспечило успех лечения.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a clinical example of the difficulty in diagnosing meningitis in a patient with unexpressed meningeal symptom complex. Among various diagnostic and therapeutic approaches, there are key research methods that have made it possible to identify the nature of the infectious process, to diagnose secondary otogenic bacterial pneumococcal meningitis, and to conduct etiotropic antibiotic therapy. The analysis of this clinical case showed that the severity of the infectious and inflammatory process was determined not only by the causative agent of Streptococcus pneumoniae, but also by the existing secondary immunodeficiency state (diabetes mellitus, implants, etc.). In connection with this, significant attention was given not only to the correction of glycemia and antimicrobial therapy, but also to antioxidant therapy, which ensured success of the treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бактериальный гнойный менингит</kwd><kwd>пневмококковый менингит</kwd><kwd>спинномозговая жидкость</kwd><kwd>маркеры воспаления</kwd><kwd>цитоз</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
