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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24411/0235-2990-2019-10057</article-id><article-id custom-type="elpub" pub-id-type="custom">antibiotics-186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности неспецифических средств медицинской защиты в отношении заболевания, вызванного вирусом Эбола</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the Effectiveness of Nonspecific Medical Protection Against Diseased, Caused of Ebola Virus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сизикова</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Sizikova</surname><given-names>T. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>V. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисевич</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisevich</surname><given-names>S. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ 48 Центральный научноFисследовательский институт Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI 48 Central Research Institute of the Ministry of Defense of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>08</day><month>05</month><year>2020</year></pub-date><volume>64</volume><issue>9-10</issue><fpage>50</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сизикова Т.Е., Лебедев В.Н., Петров А.А., Борисевич С.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Сизикова Т.Е., Лебедев В.Н., Петров А.А., Борисевич С.В.</copyright-holder><copyright-holder xml:lang="en">Sizikova T.E., Lebedev v.N., Petrov A.A., Borisevich S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/186">https://www.antibiotics-chemotherapy.ru/jour/article/view/186</self-uri><abstract><p>Представлен анализ исследований по оценке эффективности неспецифических средств экстренной профилактики и лечения заболевания, вызванного вирусом Эбола. Рассмотрены наиболее значимые результаты доклинических и клинических испытаний неспецифических средств медицинской зашиты в отношении возбудителя геморрагической лихорадки Эбола, а также перспективы их использования в практике здравоохранения в настоящее время. Установлено, что общей тенденцией создания неспецифических средств профилактики и лечения заболевания, вызванного вирусом Эбола, является не разработка новых препаратов, а попытки выявления противовирусной активности уже известных препаратов, ранее имев­ ших иное целевое назначение. В качестве наиболее эффективного НМСЗ в отношении заболевания, вызванного вирусом Эбола, рассматривается фавипиравир.</p></abstract><trans-abstract xml:lang="en"><p>The article presents an analysis of research evaluating the effectiveness of nonspecific means of emergency prevention and treatment of Ebola virus disease. It considers the most significant results of preclinical and clinical trials of nonspecific therapeutics for the causative agent of Ebola hemorrhagic fever, as well as the prospects for their use in healthcare practice at present. It has been established that the general tendency to create nonspecific means of prevention and treatment of Ebola virus disease is not the development of new drugs, but the attempts to detect the antiviral activity of already known drugs that previously had a different purpose. Favipiravir is considered as the most effective nonspecific therapeutic against Ebola virus disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вирус Эбола</kwd><kwd>геморрагическая лихорадка</kwd><kwd>лекарственные средства</kwd><kwd>препараты широкого спектра действия</kwd><kwd>экстренная профилактика и лечение</kwd><kwd>фавипиравир</kwd><kwd>интерферон</kwd><kwd>доклинические испытания</kwd><kwd>клинические испытания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Ebola virus</kwd><kwd>hemorrhagic fever</kwd><kwd>therapeutic</kwd><kwd>broad-spectrum drugs</kwd><kwd>emergency prevention and treatment</kwd><kwd>favipiravir</kwd><kwd>interferon</kwd><kwd>preclinical trials</kwd><kwd>clinical trials</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
