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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-211</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕДАКЦИОННЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EDITORIAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Резистентность к противогрибковым средствам: роль кальцинейрина и протеинкиназ</article-title><trans-title-group xml:lang="en"><trans-title>Resistance to Antimycotics: Role of Calcineurin and Protein Kinases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>54</volume><issue>3-4</issue><fpage>3</fpage><lpage>5</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитин А.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Никитин А.В.</copyright-holder><copyright-holder xml:lang="en">Nikitin A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/211">https://www.antibiotics-chemotherapy.ru/jour/article/view/211</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jamal Stie J., Fox D. Calcineurin Regulation in Fungi and Beyond. Eukaryotic Cell 2008; 7: 2: 177-186.</mixed-citation><mixed-citation xml:lang="en">Jamal Stie J., Fox D. Calcineurin Regulation in Fungi and Beyond. Eukaryotic Cell 2008; 7: 2: 177-186.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Karababa M., Valentino E., Pardini G., Coste A.T. et al. CRZ1, a target of the calcineurin pathway in Candida albicans. Mol Microbiol 2006; 59: 1429-1451.</mixed-citation><mixed-citation xml:lang="en">Karababa M., Valentino E., Pardini G., Coste A.T. et al. CRZ1, a target of the calcineurin pathway in Candida albicans. Mol Microbiol 2006; 59: 1429-1451.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Onyewu C., Wormley F.L. Jr., Perfect J.R., Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun 2004; 72: 7330-7333.</mixed-citation><mixed-citation xml:lang="en">Onyewu C., Wormley F.L. Jr., Perfect J.R., Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun 2004; 72: 7330-7333.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.</mixed-citation><mixed-citation xml:lang="en">Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005; 309: 2185-2189.</mixed-citation><mixed-citation xml:lang="en">Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005; 309: 2185-2189.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R. et al. Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 2006; 5: 2184-2188.</mixed-citation><mixed-citation xml:lang="en">Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R. et al. Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 2006; 5: 2184-2188.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cowen L.E., Steinbach W.J. Stress, drugs and evolution: the role of cellular signaling in fungal drug resistance. Eukaryotic Cell 2008; 7: 5: 747-764.</mixed-citation><mixed-citation xml:lang="en">Cowen L.E., Steinbach W.J. Stress, drugs and evolution: the role of cellular signaling in fungal drug resistance. Eukaryotic Cell 2008; 7: 5: 747-764.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jain P., Akula I., Edlind T. Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 2003; 47: 3195-3201.</mixed-citation><mixed-citation xml:lang="en">Jain P., Akula I., Edlind T. Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 2003; 47: 3195-3201.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wiederhold N.P., Kontoyiannis D.P., Prince R.A., Lewis R.E. Attenuation of the activity of caspofungin at high concentrations against Candida albicans: possible role of cell wall integrity and calcineurin pathways. Ibid 2005; 49: 5146-5148.</mixed-citation><mixed-citation xml:lang="en">Wiederhold N.P., Kontoyiannis D.P., Prince R.A., Lewis R.E. Attenuation of the activity of caspofungin at high concentrations against Candida albicans: possible role of cell wall integrity and calcineurin pathways. Ibid 2005; 49: 5146-5148.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chauhan N., Kruppa M., Calderone R. The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. Ibid; 2007; 51: 3747-3751.</mixed-citation><mixed-citation xml:lang="en">Chauhan N., Kruppa M., Calderone R. The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. Ibid; 2007; 51: 3747-3751.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Steinbach W.J., Schell W.A., Blankenship J.R., Onyewu C. et al. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Ibid; 2004; 48: 1664-1669.</mixed-citation><mixed-citation xml:lang="en">Steinbach W.J., Schell W.A., Blankenship J.R., Onyewu C. et al. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Ibid; 2004; 48: 1664-1669.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Steinbach W.J., Cramer R.A. Jr., Perfect B.Z., Henn C. et al. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Ibid; 2007; 51: 2979-2981.</mixed-citation><mixed-citation xml:lang="en">Steinbach W.J., Cramer R.A. Jr., Perfect B.Z., Henn C. et al. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Ibid; 2007; 51: 2979-2981.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Del Poeta M., Cruz M.C., Cardenas M.E., Perfect J.R. et al. Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumo-candin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Ibid; 2000; 44: 739-746.</mixed-citation><mixed-citation xml:lang="en">Del Poeta M., Cruz M.C., Cardenas M.E., Perfect J.R. et al. Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumo-candin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Ibid; 2000; 44: 739-746.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.</mixed-citation><mixed-citation xml:lang="en">Kraus P.R., Fox D.S., Cox G.M., Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol 2003; 48: 1377-1387.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kojima K., Bahn Y.S., Heitman J. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 2006; 152: 591-604.</mixed-citation><mixed-citation xml:lang="en">Kojima K., Bahn Y.S., Heitman J. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 2006; 152: 591-604.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
