antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-214Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSИзучение эффективности Ингавирина® in vitro в отношении «мексиканского» пандемического подтипа H1N1 вируса гриппа А, штаммы A/California/04/2009 и A/California/07/2009In vitro Efficacy of Ingavirin Against the Mexican Pandemic Subtype H1N1 of Influenza A Virus, Strains A/California/04/2009 and A/California/07/2009ЛогиноваС. Я.LoginovaS. YA.noemail@neicon.ruБорисевичС. В.BorisevichS. V.noemail@neicon.ruЛыковМ. В.LykovM. V.noemail@neicon.ruВеденинаЕ. В.VedeninaE. V.noemail@neicon.ruБорисевичГ. В.BorisevichG. V.noemail@neicon.ruБондаревВ. П.BondarevV. P.noemail@neicon.ruНебольсинВ. Е.NebolsinV. E.noemail@neicon.ruЧучалинА. Г.ChuchalinA. G.noemail@neicon.ruФилиал ФГУ «48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации» - «Вирусологический центр», Сергиев ПосадРоссияBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadRussian FederationОАО «Валента Фармацевтика», МоскваРоссияValenta Farmacevtica, MoscowRussian FederationНИИ пульмонологии Федерального медико-биологического агентства Российской Федерации, МоскваРоссияResearch Institute of Pulmonology, Federal Medico-Biological Agency of the Russian Federation, MoscowRussian Federation200913052020543-41517Copyright © Логинова С.Я., Борисевич С.В., Лыков М.В., Веденина Е.В., Борисевич Г.В., Бондарев В.П., Небольсин В.Е., Чучалин А.Г., 20202020Логинова С.Я., Борисевич С.В., Лыков М.В., Веденина Е.В., Борисевич Г.В., Бондарев В.П., Небольсин В.Е., Чучалин А.Г.Loginova S.Y., Borisevich S.V., Lykov M.V., Vedenina E.V., Borisevich G.V., Bondarev V.P., Nebolsin V.E., Chuchalin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/214

Ингавирин® эффективно ингибирует размножение вируса гриппа, штаммы A/California/04/2009(H1N1) и A/California/07/2009(H1N1), в культуре клеток МDСК. Коэффициент подавления цитопатической активности составил 50 и 60%, а коэффициент подавления формирования специфического гемагглютинина до обогащения в куриных эмбрионах составил 50 и 50%, после обогащения - 79,1 и 75% соответственно.

Ingavirin® was shown to be efficient in inhibition of the influenza virus strains A/California/04/2009 and A/California/07/2009 (H1N1) in the MDCK cell culture. The coefficient of the cytopathic activity inhibition amounted to 50 and 60%, and the inhibition coefficients of the specific hemagglutinin formation were 50 and 50%, and 79,1 and 75% before and after the enrichment in chick embryos respectively.

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The authors declare that there are no conflicts of interest present.