antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-241Research ArticleОБЗОРЫREVIEWSМодулирование действия ядерных рецепторов и регуляция биотрансформации лекарствModulation of Nuclear Receptor Action and Regulation of Medicines BiotransformationЛаринаС. Н.LarinaS. N.noemail@neicon.ruЧебышевН. В.ChebyshevN. V.noemail@neicon.ruШихЕ. В.ShikhE. V.noemail@neicon.ruММА им. И. М. Сеченова, МоскваРоссияI. M. Sechenov Moscow Medical Academy, MoscowRussian Federation200913052020545-66975Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/241

Ядерные рецепторы являются транскрипционными факторами, которые играют важную роль в ходе эмбрионального развития, поддержании дифференцировки клеток, метаболизме. Лиганд-регулируемый ядерный PXR рецептор взаимодействует с разнообразными химическими лигандами и лекарственными препаратами и регулирует экспрессию генов, которые участвуют в метаболизме ксенобиотиков и лекарств. Строение этого рецептора обеспечивает связывание с широким спектром лигандов, которые могут действовать как агонисты или антагонисты. Изучение модуляции действия ядерных рецепторов важно для разработки лекарственных препаратов, регулирующих метаболизм, а также при изучении взаимодействия лекарств.

Nuclear receptors are transcription factors that are essential in embryonic development, cellular differentiation, metabolism . Ligand-regulated nuclear PXR receptor responds to diverse arrays of chemically distinct ligands , xenobiotics, drugs and regulates expression of the genes involved in xenobiotic and drug metabolism. The structural basis of the receptor provides interaction with a variety of ligands which are agonists or antagonists. Nuclear receptors researches are important for design of metabolism regulating drugs and in drug interaction studies.

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The authors declare that there are no conflicts of interest present.