<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-253</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Интерфероны первого типа — индукция и механизмы противовирусного действия</article-title><trans-title-group xml:lang="en"><trans-title>Type 1 Interferons: Induction and Mechanisms of Antiviral Action</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyev</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малиновская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malinovskaya</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парфенов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Parfenov</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitrieva</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт доклинической и клинической экспертизы лекарственных средств ФГУ НЦЭСМП, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Preclinical and Clinical Investigation of Drugs, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н. Ф. Гамалеи РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>54</volume><issue>7-8</issue><fpage>50</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильев А.Н., Малиновская В.В., Парфенов В.В., Дмитриева Е.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Васильев А.Н., Малиновская В.В., Парфенов В.В., Дмитриева Е.В.</copyright-holder><copyright-holder xml:lang="en">Vasilyev A.N., Malinovskaya V.V., Parfenov V.V., Dmitrieva E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/253">https://www.antibiotics-chemotherapy.ru/jour/article/view/253</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Isaacs A., Lindenmann J. Virus interference. I. The interferon. Proc R. Soc Lond B Biol Sci 1957; 147: 258—267</mixed-citation><mixed-citation xml:lang="en">Isaacs A., Lindenmann J. Virus interference. I. The interferon. Proc R. Soc Lond B Biol Sci 1957; 147: 258—267</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cantell K., Hirvonen S., Kauppinen H. L., Myllyla G. Production of interferon in human leukocytes from normal donors with the use of Sendai virus. Methods Enzymol. 1981; 78: 29—38</mixed-citation><mixed-citation xml:lang="en">Cantell K., Hirvonen S., Kauppinen H. L., Myllyla G. Production of interferon in human leukocytes from normal donors with the use of Sendai virus. Methods Enzymol. 1981; 78: 29—38</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Friesen H. J., Stein S., Evinger M. et al. Purification and molecular characterization of human fibroblast interferon. Arch Biochem Biophys 1981; 206: 432—450</mixed-citation><mixed-citation xml:lang="en">Friesen H. J., Stein S., Evinger M. et al. Purification and molecular characterization of human fibroblast interferon. Arch Biochem Biophys 1981; 206: 432—450</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rubinstein M., Rubinstein S., Familetty P. C. et al. Human leukocyte interferon purified to homogeneity. Science 1978; 202: 1289—1290.</mixed-citation><mixed-citation xml:lang="en">Rubinstein M., Rubinstein S., Familetty P. C. et al. Human leukocyte interferon purified to homogeneity. Science 1978; 202: 1289—1290.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Stein S., Kenny C., Fnesen H. J. et al. NH2-Terminal amino acid sequence of human fibroblast interferon. Proc Natl Acad Sci USA 1980; 77: 5716—5719.</mixed-citation><mixed-citation xml:lang="en">Stein S., Kenny C., Fnesen H. J. et al. NH2-Terminal amino acid sequence of human fibroblast interferon. Proc Natl Acad Sci USA 1980; 77: 5716—5719.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Maeda S., McCandliss R., Gross M. et al. Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Ibid; 7010—7013.</mixed-citation><mixed-citation xml:lang="en">Maeda S., McCandliss R., Gross M. et al. Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Ibid; 7010—7013.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nagata S., Taira H., Hall A. et al. Synthesis in E.coli of a polypeptide with human leukocyte interferon activity. Nature 1980; 284: 316—320.</mixed-citation><mixed-citation xml:lang="en">Nagata S., Taira H., Hall A. et al. Synthesis in E.coli of a polypeptide with human leukocyte interferon activity. Nature 1980; 284: 316—320.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Goeddel D. V., Yelverton E., Ullrich A. et al. Human leukocyte interferon produced by E.coli is biologically active. Ibid; 287; 411—416.</mixed-citation><mixed-citation xml:lang="en">Goeddel D. V., Yelverton E., Ullrich A. et al. Human leukocyte interferon produced by E.coli is biologically active. Ibid; 287; 411—416.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Derynck R., Content J., DeClercq E. Isolation and structure of human fibroblast interferon gene. Ibid; 285: 542—547.</mixed-citation><mixed-citation xml:lang="en">Derynck R., Content J., DeClercq E. Isolation and structure of human fibroblast interferon gene. Ibid; 285: 542—547.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Houghton M., Stewart A. G., Doel S. M. et al. The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. Nucleic Acids Res 1980; 8: 1913—1931.</mixed-citation><mixed-citation xml:lang="en">Houghton M., Stewart A. G., Doel S. M. et al. The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. Nucleic Acids Res 1980; 8: 1913—1931.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Taniguchi T., Ohno S., Fujii-Kuriyama Y. et al. The nucleotide sequence of human fibroblast interferon cDNA. Gene; 1980: 10: 11—15.</mixed-citation><mixed-citation xml:lang="en">Taniguchi T., Ohno S., Fujii-Kuriyama Y. et al. The nucleotide sequence of human fibroblast interferon cDNA. Gene; 1980: 10: 11—15.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Biron C. A., Sen G. C. Interferons and other cytokines, p. 321—351 // In D. M. Knipe, P. M. Howley, D. E. Griffin, M. Martin, B. Roizman and S. E. Straus (ed.) Fields virology. 2001. 4th ed. Lippincott-Raven; Philadelphia, Pa.</mixed-citation><mixed-citation xml:lang="en">Biron C. A., Sen G. C. Interferons and other cytokines, p. 321—351 // In D. M. Knipe, P. M. Howley, D. E. Griffin, M. Martin, B. Roizman and S. E. Straus (ed.) Fields virology. 2001. 4th ed. Lippincott-Raven; Philadelphia, Pa.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pestka S. The Interferons: 50 years after their discovery, there is much more to learn. Journ of Biol Chem 2007; 282: 28: 20047—20051.</mixed-citation><mixed-citation xml:lang="en">Pestka S. The Interferons: 50 years after their discovery, there is much more to learn. Journ of Biol Chem 2007; 282: 28: 20047—20051.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Foster G. R., Germain C., JonesM. et al. Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. Eur J Immunol 2000; 30: 3228—3235.</mixed-citation><mixed-citation xml:lang="en">Foster G. R., Germain C., JonesM. et al. Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. Eur J Immunol 2000; 30: 3228—3235.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bach E. A., Agreet M., Schreiber R. D. The IFN gamma receptor: a paradigm for cytokine receptor signalling. Annu Rev Immunol 1997; 15: 563—591.</mixed-citation><mixed-citation xml:lang="en">Bach E. A., Agreet M., Schreiber R. D. The IFN gamma receptor: a paradigm for cytokine receptor signalling. Annu Rev Immunol 1997; 15: 563—591.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Malmgaard L. Induction and regulation of IFNs during viral infection. J Interferon and Cytokine Res 2004; 24: 8: 439—454.</mixed-citation><mixed-citation xml:lang="en">Malmgaard L. Induction and regulation of IFNs during viral infection. J Interferon and Cytokine Res 2004; 24: 8: 439—454.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783—801.</mixed-citation><mixed-citation xml:lang="en">Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783—801.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Matsumoto M., Funami K., Tanabe M. et al. Subcellular localization of toll-like receptor 3 in human dendritic cells. J Immunol 2003; 171: 3154—3162.</mixed-citation><mixed-citation xml:lang="en">Matsumoto M., Funami K., Tanabe M. et al. Subcellular localization of toll-like receptor 3 in human dendritic cells. J Immunol 2003; 171: 3154—3162.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Choe J., Kelker M. S., Wilson I. A. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005; 309: 581—585.</mixed-citation><mixed-citation xml:lang="en">Choe J., Kelker M. S., Wilson I. A. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005; 309: 581—585.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto M., Sato S., Hemmi H. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signalling pathway. Science 2003; 301; 640—643.</mixed-citation><mixed-citation xml:lang="en">Yamamoto M., Sato S., Hemmi H. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signalling pathway. Science 2003; 301; 640—643.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hoebe K., Du X., Georgel P. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003; 424; 743—748.</mixed-citation><mixed-citation xml:lang="en">Hoebe K., Du X., Georgel P. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003; 424; 743—748.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hemmi H., Takeuchi O., Sato S. et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharides and double stranded RNA signalling and viral infection. J Exp Med 2004; 199: 1641—1650.</mixed-citation><mixed-citation xml:lang="en">Hemmi H., Takeuchi O., Sato S. et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharides and double stranded RNA signalling and viral infection. J Exp Med 2004; 199: 1641—1650.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Perry A. K., Chow E. K., Goodnough J. B. Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med 2004; 199: 1651—1658.</mixed-citation><mixed-citation xml:lang="en">Perry A. K., Chow E. K., Goodnough J. B. Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med 2004; 199: 1651—1658.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Uematsu S., Akira S. Toll-like receptors and type I interferons. J of Biol Chem 2006; 282: 21: 15319—15323.</mixed-citation><mixed-citation xml:lang="en">Uematsu S., Akira S. Toll-like receptors and type I interferons. J of Biol Chem 2006; 282: 21: 15319—15323.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Takeda K., Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17: 1—14.</mixed-citation><mixed-citation xml:lang="en">Takeda K., Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17: 1—14.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Honda K., Taniguchi T. IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006; 6: 644—658.</mixed-citation><mixed-citation xml:lang="en">Honda K., Taniguchi T. IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006; 6: 644—658.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kurt-Jones E. A., Popova L., Kwinn L. et al. Pattern-recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1: 398—401.</mixed-citation><mixed-citation xml:lang="en">Kurt-Jones E. A., Popova L., Kwinn L. et al. Pattern-recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1: 398—401.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rassa J. C., Meyers J. L., Zhang Y. et al. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 2002; 99: 2281—2286.</mixed-citation><mixed-citation xml:lang="en">Rassa J. C., Meyers J. L., Zhang Y. et al. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 2002; 99: 2281—2286.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">McGettrick A. F., Brint E. K., Palsson-McDermott E. M. et al. Trif-related adapter molecule is phosphorylated by PKCe during toll-like receptor 4 signalling. Ibid 2006; 103: 9196—9201.</mixed-citation><mixed-citation xml:lang="en">McGettrick A. F., Brint E. K., Palsson-McDermott E. M. et al. Trif-related adapter molecule is phosphorylated by PKCe during toll-like receptor 4 signalling. Ibid 2006; 103: 9196—9201.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Compton T., Kurt-Jones E.A., Boehme K. W. et al. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2. J of Virol 2003; 77: 8: 4588—4596.</mixed-citation><mixed-citation xml:lang="en">Compton T., Kurt-Jones E.A., Boehme K. W. et al. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2. J of Virol 2003; 77: 8: 4588—4596.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kurt-Jones E. A., Chan M., Zhou S. et al. Herpes simplex virus 1 interaction with toll-like receptor 2 contributes to lethal encephalitis. PNAS 2004; 101: 5: 1315—1320.</mixed-citation><mixed-citation xml:lang="en">Kurt-Jones E. A., Chan M., Zhou S. et al. Herpes simplex virus 1 interaction with toll-like receptor 2 contributes to lethal encephalitis. PNAS 2004; 101: 5: 1315—1320.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Meylan E., Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Molecular Cell 2006; 22: 561—569.</mixed-citation><mixed-citation xml:lang="en">Meylan E., Tschopp J. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Molecular Cell 2006; 22: 561—569.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pestka S., Langer J. A. , Zoon K. C., Samuel C. E. Interferons and their actions. Ann Rev Biochem 1987; 56: 317—332.</mixed-citation><mixed-citation xml:lang="en">Pestka S., Langer J. A. , Zoon K. C., Samuel C. E. Interferons and their actions. Ann Rev Biochem 1987; 56: 317—332.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Samuel C. E. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 1991; 183: 1—11.</mixed-citation><mixed-citation xml:lang="en">Samuel C. E. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 1991; 183: 1—11.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Stark G. R., Kerr J.M., Williams B. R. et al. How cells respond to interferons. Ann Rev Biochem 1998; 67: 227—264.</mixed-citation><mixed-citation xml:lang="en">Stark G. R., Kerr J.M., Williams B. R. et al. How cells respond to interferons. Ann Rev Biochem 1998; 67: 227—264.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Knipe D. M., Samuel C. E., Palese P. Virus-host cell interactions, p. 133—170 // In D. M. Knipe, P. M. Howley, D. E. Griffin, M. Martin, B. Roizman and S. E. Straus (ed.) Fields virology, 2001. 4th ed. Lippincott-Raven; Philadelphia, Pa.</mixed-citation><mixed-citation xml:lang="en">Knipe D. M., Samuel C. E., Palese P. Virus-host cell interactions, p. 133—170 // In D. M. Knipe, P. M. Howley, D. E. Griffin, M. Martin, B. Roizman and S. E. Straus (ed.) Fields virology, 2001. 4th ed. Lippincott-Raven; Philadelphia, Pa.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Samuel C. E. Antiviral actions of interferons. Clin Microbiol Rev 2001; 14: 4: 778—809.</mixed-citation><mixed-citation xml:lang="en">Samuel C. E. Antiviral actions of interferons. Clin Microbiol Rev 2001; 14: 4: 778—809.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mogensen K. E., Lewerenz M., Reboul J. et al. The type I interferon receptor: structure, function and evolution of a family business. J Interferon Cytokine Res 1999; 19: 1069—1098.</mixed-citation><mixed-citation xml:lang="en">Mogensen K. E., Lewerenz M., Reboul J. et al. The type I interferon receptor: structure, function and evolution of a family business. J Interferon Cytokine Res 1999; 19: 1069—1098.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Deweerd N. A., Shamith A., Samarajiwa, P. J. Hertzog. Type I interferon receptors: biochemistry and biological functions. J Biol Chem 2007; 282: 28: 20053—20057.</mixed-citation><mixed-citation xml:lang="en">Deweerd N. A., Shamith A., Samarajiwa, P. J. Hertzog. Type I interferon receptors: biochemistry and biological functions. J Biol Chem 2007; 282: 28: 20053—20057.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Heim M. H. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J Receptor Signal Transduction Res 1999; 9: 75—120.</mixed-citation><mixed-citation xml:lang="en">Heim M. H. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J Receptor Signal Transduction Res 1999; 9: 75—120.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Shindler C., Levy D. E., Decker T. JAK-STAT signalling: from interferons to cytokines. J Biol Chem 2007; 282: 28: 20059—20063.</mixed-citation><mixed-citation xml:lang="en">Shindler C., Levy D. E., Decker T. JAK-STAT signalling: from interferons to cytokines. J Biol Chem 2007; 282: 28: 20059—20063.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ozato K., Tailor P., Kubota T. The interferons regulatory factor family in host defense: mechanism of action. Ibid; 20065—20069.</mixed-citation><mixed-citation xml:lang="en">Ozato K., Tailor P., Kubota T. The interferons regulatory factor family in host defense: mechanism of action. Ibid; 20065—20069.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Platanias L. C. Mechanisms of type-I and type-II-interferon-mediated signalling. Nat Rev Immunol 2005; 5: 375—386.</mixed-citation><mixed-citation xml:lang="en">Platanias L. C. Mechanisms of type-I and type-II-interferon-mediated signalling. Nat Rev Immunol 2005; 5: 375—386.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Gil M. P., Bohn E., O'Guin A. K. et al. Biologic consequences of STAT-1-independent IFN-signalling. Proc Natl Acad Sci USA 2001; 98: 6680—6685.</mixed-citation><mixed-citation xml:lang="en">Gil M. P., Bohn E., O'Guin A. K. et al. Biologic consequences of STAT-1-independent IFN-signalling. Proc Natl Acad Sci USA 2001; 98: 6680—6685.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Gil J., Alcami J., Esteban M. Induction of apoptosis by double-stranded RNA-dependent protein kinase PKR involves the a subunit of eucariotic translation initiation factor 2 and NF-kB. Mol Cell Biol 19: 4653—4663.</mixed-citation><mixed-citation xml:lang="en">Gil J., Alcami J., Esteban M. Induction of apoptosis by double-stranded RNA-dependent protein kinase PKR involves the a subunit of eucariotic translation initiation factor 2 and NF-kB. Mol Cell Biol 19: 4653—4663.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Barber G. N. Host defence, viruses and apoptosis. Cell Death Differ 2001; 8: 2: 113—126.</mixed-citation><mixed-citation xml:lang="en">Barber G. N. Host defence, viruses and apoptosis. Cell Death Differ 2001; 8: 2: 113—126.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Le Bon A., Schiavoni G., D'Agostino G. et al. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 2001; 14: 461—70.</mixed-citation><mixed-citation xml:lang="en">Le Bon A., Schiavoni G., D'Agostino G. et al. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 2001; 14: 461—70.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Biron C. A. Role of early cytokines, including a and β interferons (IFN a/β), in innate and adaptive immune responses to viral infections. Semin Immunol 1998; 5: 383—390.</mixed-citation><mixed-citation xml:lang="en">Biron C. A. Role of early cytokines, including a and β interferons (IFN a/β), in innate and adaptive immune responses to viral infections. Semin Immunol 1998; 5: 383—390.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Pien G. C., Nguyen B., Malmgaard L. et al. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 2002; 169: 5827—5837.</mixed-citation><mixed-citation xml:lang="en">Pien G. C., Nguyen B., Malmgaard L. et al. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 2002; 169: 5827—5837.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Sastre A., Biron C. A. Type 1 intreferons and the virus-host relationship: a lesson in detente. Science 2006; 312: 879—882.</mixed-citation><mixed-citation xml:lang="en">Garcia-Sastre A., Biron C. A. Type 1 intreferons and the virus-host relationship: a lesson in detente. Science 2006; 312: 879—882.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
