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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-317</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Изучение активности препарата Люромарин in vitro в отношении вируса клещевого энцефалита</article-title><trans-title-group xml:lang="en"><trans-title>In vitro Activity of Luromarin Against Tick-Borne Encephalitis Virus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Leonova</surname><given-names>G. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майстровская</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maistrovskaya</surname><given-names>O. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артюков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Artyukov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козловская</surname><given-names>Э. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlovskaya</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ эпидемиологии и микробиологии СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Epidemiology and Microbiology of the Siberian Branch of the Russian Academy of Medical Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тихоокеанский институт биоорганической химии ДВО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pacific Institute of Bioorganic Chemistry, Ear-East Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>55</volume><issue>7-8</issue><fpage>17</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ООО «Издательство ОКИ», 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">ООО «Издательство ОКИ»</copyright-holder><copyright-holder xml:lang="en">ООО «Издательство ОКИ»</copyright-holder><license xlink:href="https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/317">https://www.antibiotics-chemotherapy.ru/jour/article/view/317</self-uri><abstract><p>Препарат Люромарин, выделенный из морской травы Zostera asiatica, не оказывает цитотоксическое действие в культуре клеток СПЭВ, характеризуется вирулицидными свойствами в отношении высокопатогенного штамма вируса КЭ и способностью подавлять продукцию этого вируса на ранних стадиях развития инфекции.</p></abstract><trans-abstract xml:lang="en"><p>Luromarin, extracted from the sea alga Zostera asiatica, showed no cytotoxic activity when incubated with the SPEV cell culture and was characterized by virulicidal properties against highly pathogenic strain of TBE virus and the ability to inhibit the virus replication at the early stages of the infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вирус клещевого энцефалита</kwd><kwd>розмариновая кислота</kwd><kwd>противовирусная активность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tick-borne encephalitis</kwd><kwd>rosmarinic acid</kwd><kwd>antiviral activity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Debersac P., Vernevaut M. 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