antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-373Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSПопуляционная структура пневмококков со сниженной чувствительностью к пенициллину и перспективы антипневмококковой вакцинации для сдерживания распространения антибактериальной резистентностиPopulation Pattern of Pneumococci with Lower Susceptibility to Penicillin and Prospects of Antipneumococcal Vaccination to Control Antibiotic Resistance DistributionСидоренкоС. В.SidorenkoS. V.noemail@neicon.ruСавиноваТ. А.SavinovaT. A.noemail@neicon.ruИльинаЕ. Н.IlyinaE. N.noemail@neicon.ruСырочкинаМ. А.SyrochkinaM. A.noemail@neicon.ruНаучно-исследовательский институт детских инфекций, Санкт-Петербург; Санкт-Петербургская государственная медицинская академия им. И. И. МечниковаРоссияReserch Institute of Children's Infections, St.Petersburg; I.I. Mechnikov St.Petersburg State Medical AcademyRussian FederationНациональное агентство клинической фармакологии и фармации, МоскваРоссияNational Agency of Clinical Pharmacology and Pharmacy, MoscowRussian FederationНаучно-исследовательский институт физико-химической медицины, МоскваРоссияResearch Institute of Physico-Chemical Medicine, MoscowRussian FederationУральская государственная медицинская академия, ЕкатеринбургРоссияUrals State Medical Academy, EkaterinburgRussian Federation201113052020565-61118Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/373

Массовая антипневмококковая вакцинация сопровождается изменениями в серотиповом составе и уровне антибиотико-резистентности пневмококков. Целью настоящей работы была оценка серотипового состава и популяционной структуры пневмококков со сниженной чувствительностью к пенициллину до начала массовой антипневмококковой вакцинации. Среди 260 изолятов Streptococcus pneumoniae, выделенных в Российской Федерации в 2003-2007 гг., чаще всего встерча-лись серотипы 23F (37,2%) и 19F (13,9%). К серогруппе 6 относились 19,3% изолятов; по 3,6% изолятов относились к се-ротипу 3 и серогруппе 18; 4,9% изолятов - к серотипу 14; 2,2% - к серотипу 19А. К серотипам, входящим в 7-валентную конъюгированную пневмококковую вакцину, относились 66,8% изолятов, в 10-валентную - 67,3%, в 13-валентную - 82,1%. Изоляты со сниженной чувствительнстью к пенициллину характеризовались выраженной клональностью, 56.9% их них относились к четырём глобальным клональным комплексам (СС81, СС156, СС320 и СС315). Включение конъюгированной антипневмококковой вакцины в национальный календарь прививок Российской Федерации может способствовать снижению уровня антибиотикорезистентности среди пневмококков.

Large-scale antipneumococcal vaccination is followed by changes in the serotype composition and level of antibiotic resistance in pneumococci. The aim of the study was to evaluate the serotype composition and population pattern of pneumococci with lower susceptibility to penicillin before large-scale antipneumococcal vaccination. Among 260 Streptococcus pneumoniae strains isolated in the Russian Federation within 2003-2007, serotypes 23F (37.2%) and 19F (13.9%) were the most frequent ones. 19.3% of the isolates belonged to serogroup 6, 3.6% of the isolates each belonged to serotype 3 and serogroup 18, 4.9% of the isolates belonged to serotype 14 and 2.2% of the isolates belonged to serotype 19A. 66.8% of the isolates belonged to serotypes of the 7-valent conjugated pneumococcal vaccine, 67.3 and 82.1% of the isolates belonged to the 10- and 13-valent conjugated pneumococcal vaccines respectively. The isolates with lower susceptibility to penicillin were characterized by significant clonality and 56.9% of them belonged to 4 global clonal complexes (CC81, CC156, CC320 and CC315). Inclusion of the conjugated antipneumococcal vaccine to the National Vaccination Time-Table of the Russian Federation could promote lower levels of antibiotic resistance in pneumococci.

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The authors declare that there are no conflicts of interest present.