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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-429</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ АЗИТРОМИЦИНА И ЕГО ВЛИЯНИЕ НА СОСТОЯНИЕ ЦИТОКИНОВОЙ СИСТЕМЫ ПРИ УРОГЕНИТАЛЬНЫХ ИНФЕКЦИЯХ</article-title><trans-title-group xml:lang="en"><trans-title>EFFICACY OF AZITHROMYCIN AND ITS IMPACT IN CYTOKINE SYSTEM IN UROGENITAL INFECTIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хрянин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khryanin</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Решетников</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reshetnikov</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафронов</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Safronov</surname><given-names>I. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трунов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trunov</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликова</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikova</surname><given-names>N. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет Минздравсоцразвития России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт терапии СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет Минздравсоцразвития России; Научный центр клинической и экспериментальной медицины СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; Scientific Centre of Clinical and Experimental Medicine, Siberian Branch of Russian Academy of Medicals Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научный центр клинической и экспериментальной медицины СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Centre of Clinical and Experimental Medicine, Siberian Branch of Russian Academy of Medicals Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>57</volume><issue>3-4</issue><fpage>29</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хрянин А.А., Решетников О.В., Сафронов И.Д., Трунов А.Н., Куликова Н.Б., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Хрянин А.А., Решетников О.В., Сафронов И.Д., Трунов А.Н., Куликова Н.Б.</copyright-holder><copyright-holder xml:lang="en">Khryanin A.A., Reshetnikov O.V., Safronov I.D., Trunov A.N., Kulikova N.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/429">https://www.antibiotics-chemotherapy.ru/jour/article/view/429</self-uri><abstract><p>В исслелование было включено 75 больных с хламидийной и микоплазменной урогенитальной инфекцией. При провелении этиотропной терапии использовался азитромицин в курсовой лозе 1,0-1,5 г в зависимости от выявленной инфекции. Результаты терапии азитромицином, кроме высокого уровня эрадикации, свидетельствуют о её влиянии на уровень цитокинов в организме больных, что характеризуется достоверным повышением содержания ИНФ-γ и снижением ИЛ-1β и ИЛ-6 в крови.</p></abstract><trans-abstract xml:lang="en"><p>Seventy five patients with urogenital chlamydial and mycoplasmic infections were enrolled in the trial. In the etiotropic therapy azithromycin was used in the standard dosage (1.0-1.5 g) depending on the infection. The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-γ level and a decrease of the IL-β and IL-6 levels in the blood.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>урогенитальная инфекция</kwd><kwd>азитромицин</kwd><kwd>цитокины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>C.trachomatis</kwd><kwd>M.genitalium</kwd><kwd>C.trachomatis</kwd><kwd>M.genitalium</kwd><kwd>urogenital infection</kwd><kwd>azithromycin</kwd><kwd>cytokines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Брико Н. И., Лыткина И. H., Абоймова О. А. Принципы эпидемиологического надзора за болезнями, передающимися половым путем. Эпидемиол инфекц бол 2004; 2: 11-15.</mixed-citation><mixed-citation xml:lang="en">Брико Н. И., Лыткина И. 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