antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-46Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSБиологическая активность липосомного силибининаBiological Activity of Liposomal SilibininФельдманН. Б.FeldmanN. B.n_feldman@mail.ruГудковаО. И.GudkovaO. I.noemail@neicon.ruКурьяковВ. Н.KuryakovV. N.noemail@neicon.ruГромовыхТ. И.GromovykhT. I.noemail@neicon.ruБарановаА. А.BaranovaA. A.noemail@neicon.ruСадыковаВ. С.SadykovaV. S.noemail@neicon.ruЛуценкоС. В.LutsenkoS'. V.noemail@neicon.ruПервый московский государственный медицинский университет им. И. М. СеченоваРоссияI. M. Sechenov First Moscow State Medical UniversityRussian FederationИнститут проблем нефти и газа РАНРоссияOil and Gas Research Institute RASRussian FederationНИИ по изысканию новых антибиотиков им. Г.Ф. ГаузеРоссияGause Institute of New AntibioticsRussian Federation201706052020629-10914Copyright © Фельдман Н.Б., Гудкова О.И., Курьяков В.Н., Громовых Т.И., Баранова А.А., Садыкова В.С., Луценко С.В., 20202020Фельдман Н.Б., Гудкова О.И., Курьяков В.Н., Громовых Т.И., Баранова А.А., Садыкова В.С., Луценко С.В.Feldman N.B., Gudkova O.I., Kuryakov V.N., Gromovykh T.I., Baranova A.A., Sadykova V.S., Lutsenko S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/46

Цель работы - получение и характеристика липосомного силибинина, а также исследование его противоопухолевой и антимикробной активности. Липосомы получали методом гидратации тонкослойной пленки буферным раствором с последующим многократным замораживанием-оттаиванием дисперсии фосфатидилхолин-холестерин-силибинин. Установлено, что липосомный силибинин проявляет ингибирующий эффект в отношении опухолевых клеток печени (линия HepG2) и предстательной железы (линия DU145). Кроме того, липосомный силибинин оказывает выраженное антибактериальное действие в отношении бактерий и фунгистатическое действие в отношении токсигенных микромицетов, что может свидетельствовать о его эффективности как антимикробного средства и фунгистатика для снижения негативного действия микотоксинов плесневых грибов.

The aim of the study was to obtain and characterize liposomal silibinin, as well as to study its antitumor and antimicrobial activity. Liposomes were obtained by hydration of a thin-layer film with a buffer solution followed by multiple freezing-thawing of the dispersion of phosphatidylcholine-cholesterol-silibinin. It has been established that liposomal silibinin has an inhibitory effect against liver (HepG2 line) and prostate gland (DU145 line) tumor cells. In addition, liposomalosilinin has a pronounced antibacterial effect against bacteria and a fungistatic effect on toxigenic micromycetes, which may indicate its effectiveness as an antimicrobial and fungistatic agent for reducing the negative effect of mycotoxins of mold fungi.

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The authors declare that there are no conflicts of interest present.