<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-498</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>Роль внутрикостного введения антибиотиков при лечении местнораспространенного рака слизистой оболочки полости рта</article-title><trans-title-group xml:lang="en"><trans-title>Role of Intraosteal Administration of Antibiotics in Treatment of Local Oral Mucinous Carcinoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шейкин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheikin</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ АО Областной онкологический диспансер</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Oncologic Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ АО Стоматологическая поликлиника № 4</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Stomatologic Polyclinic No. 4</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>58</volume><issue>7-8</issue><fpage>30</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванов В.М., Иванова О.В., Шейкин М.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Иванов В.М., Иванова О.В., Шейкин М.В.</copyright-holder><copyright-holder xml:lang="en">Ivanov V.M., Ivanova O.V., Sheikin M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/498">https://www.antibiotics-chemotherapy.ru/jour/article/view/498</self-uri><abstract><p>Статья посвящена вопросам профилактики инфекционных осложнений при лечении местнораспространённого рака слизистой оболочки полости рта у 204 больных. Убедительно показано, что для улучшения непосредственных результатов комбинированного и комплексного лечении этих больных лучшие показатели отмечаются при мультидисциплинарном подходе к оказанию помощи этим больным с обязательным привлечением стоматолога. Проведение специальных стоматологических профилактических и лечебных мероприятий с использованием реамберина местно и внутривенно при химиолучевой терапии и адекватной антибиотикотерапии в периоперационном периоде приводит к снижению инфекционных осложнений, что в конечном итоге сказывается на качестве жизни этих больных. Установлено преимущество внутрикостного введения антибиотиков.</p></abstract><trans-abstract xml:lang="en"><p>The problems of prophylaxis of infectious complications in the treatment of oral local mucinous carcinoma are considered relevant to 204 respective cases. More favourable results of the combined and complex treatment of the patients were shown when a multidisciplinary approach was used with obligatory participation of stomatologists. Special stomatologic prophylactic and therapeutic procedures with using reamberin orally and intravenously in the chemo- and radiotherapy and adequate antibiotic therapy during the surgical operation resulted in less frequent infectious complications, that was in favour of the patients life quality. Intraosteal administration of antibiotics was shown preferable.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак полости рта</kwd><kwd>остеомиелит</kwd><kwd>лучевая терапия</kwd><kwd>реамберин</kwd><kwd>цитостатики</kwd><kwd>антибиотики</kwd><kwd>внутрикостное введение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oral cavity cancer</kwd><kwd>osteomyelities</kwd><kwd>radiotherapy</kwd><kwd>reamberin</kwd><kwd>cytostatics</kwd><kwd>antibiotics</kwd><kwd>intraosteal administration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М.И., Аксель E.М. Заболеваемость злокачественными новообразованиями. Вестн РОНЦ им. H.Н. Блохина 2010; 2: 21: 58-59.</mixed-citation><mixed-citation xml:lang="en">Давыдов М.И., Аксель E.М. Заболеваемость злокачественными новообразованиями. Вестн РОНЦ им. H.Н. Блохина 2010; 2: 21: 58-59.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Козлова C.H., Козлова Р.С. Антибактериальные препараты в клинической практике. М.: 2009, 146-155.</mixed-citation><mixed-citation xml:lang="en">Козлова C.H., Козлова Р.С. Антибактериальные препараты в клинической практике. М.: 2009, 146-155.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Святославов Д.С. Этиологическая структура раневых инфекций у больных опухолями головы и шеи. Антибиотики и химиотер. 2006; 11-12: 36-44.</mixed-citation><mixed-citation xml:lang="en">Святославов Д.С. Этиологическая структура раневых инфекций у больных опухолями головы и шеи. Антибиотики и химиотер. 2006; 11-12: 36-44.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Матякии E.Г., Кропотов M.A. Сборник тез.: Онкология на рубеже XXI века. Возможности и перспективы. М.: 1999: 231.</mixed-citation><mixed-citation xml:lang="en">Матякии E.Г., Кропотов M.A. Сборник тез.: Онкология на рубеже XXI века. Возможности и перспективы. М.: 1999: 231.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Пачес А.И. и др. Злокачественные опухоли полости рта, глотки и гортани. М.: Медицина, 1998; 304.</mixed-citation><mixed-citation xml:lang="en">Пачес А.И. и др. Злокачественные опухоли полости рта, глотки и гортани. М.: Медицина, 1998; 304.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jatin P., Shah J.P. Role of surgery and the surgeon in the treatment of head and neck tumors. Oncosurgery 2009; 1: 2: 12.</mixed-citation><mixed-citation xml:lang="en">Jatin P., Shah J.P. Role of surgery and the surgeon in the treatment of head and neck tumors. Oncosurgery 2009; 1: 2: 12.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Leemans R. Oral Cancer. Международный конгресс «Современные аспекты хирургии и онкологии головы и шеи». СПб.: 2010; 43-46.</mixed-citation><mixed-citation xml:lang="en">Leemans R. Oral Cancer. Международный конгресс «Современные аспекты хирургии и онкологии головы и шеи». СПб.: 2010; 43-46.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Olmi P., Crispino S., Fallai C. et al. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy - a multicenter randomized trial. Int J Radiat Oncol Biol Phys 2003; 55: 1: 78-92.</mixed-citation><mixed-citation xml:lang="en">Olmi P., Crispino S., Fallai C. et al. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy - a multicenter randomized trial. Int J Radiat Oncol Biol Phys 2003; 55: 1: 78-92.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pignon J., Bourhis J., Domenge C. et al. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three metaanalysis of updated individual data. MACHNC collaborative group. Metaanalysis of chemotherapy on head and neck cancer. Lancet 2000; 355:3: 949-955.</mixed-citation><mixed-citation xml:lang="en">Pignon J., Bourhis J., Domenge C. et al. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three metaanalysis of updated individual data. MACHNC collaborative group. Metaanalysis of chemotherapy on head and neck cancer. Lancet 2000; 355:3: 949-955.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Toth B., Chambers M.S., Fleming F. Prevention and management of oral complications associated with cancer therapies radiotherapy (chemotherapy). Texas Dent J 1996; 113: 6: 23-29.</mixed-citation><mixed-citation xml:lang="en">Toth B., Chambers M.S., Fleming F. Prevention and management of oral complications associated with cancer therapies radiotherapy (chemotherapy). Texas Dent J 1996; 113: 6: 23-29.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
