antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-530Research ArticleОБЗОРЫREVIEWSДействие антибиотиков как сигнальных молекулAction of Antibiotics as Signalling MoleculesБулгаковаВ. Г.BulgakovaV. G.noemail@neicon.ruВиноградоваК. А.VinogradovaK. A.noemail@neicon.ruОрловаТ. И.OrlovaT. I.noemail@neicon.ruКожевинП. А.KozhevinP. A.noemail@neicon.ruПолинА. Н.PolinA. N.noemail@neicon.ruМосковский государственный университет им. М.В. ЛомоносоваРоссияM.V. Lomonosov Moscow State University, MoscowRussian Federation201413052020591-23643Copyright © Булгакова В.Г., Виноградова К.А., Орлова Т.И., Кожевин П.А., Полин А.Н., 20202020Булгакова В.Г., Виноградова К.А., Орлова Т.И., Кожевин П.А., Полин А.Н.Bulgakova V.G., Vinogradova K.A., Orlova T.I., Kozhevin P.A., Polin A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/530

Ранее предполагалось, что в природных условиях почвенные микроорганизмы продуцируют антибиотики только для подавления роста конкурентов. В настоящее время показано, что в субингибигорных концентрациях антибиотики выполняют роль сигнальных молекул в качестве средства коммуникации в микробной популяции. Антибиотики как сигнальные молекулы модулируют транскрипцию генов и регулируют их экспрессию. Субингибиторные концентрации антибиотиков могут вызывать фенотипические и генотипические изменения у микроорганизмов. Подобные транскрипционные изменения зависят от взаимодействия антибиотиков с такими макромолекулярными рецепторами, как рибосомы и РНК-полимераза. Действие антибиотиков как сигнальных молекул и кворум-сенсинг система являются регуляторными механизмами у микроорганизмов. Показано влияние антибиотиков как сигнальных молекул на систему кворум-сенсинга.

It was thought that antibiotics should be produced by soil microorganisms to inhibit the growth of competitors in natural habitats. Yet it has been shown that antibiotics at subinhibitory concentrations may have a role as signalling molecules providing cell-to-cell communication in bacteria in the environment. Antibiotics modulate gene transcription and regulate gene expression in microbial populations. Subinhibitory concentrations of antibiotics may cause a number of phenotypic and genotypic changes in microorganisms. These transcription changes are dependent on the interaction of antibiotics with macromolecular receptors such as ribosome or RNA-polymerase. Antibiotic signalling and quorum-sensing system are important regulatory mechanisms in bacteria. It was demonstrated that antibiotics interfered with quorum-sensing system.

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The authors declare that there are no conflicts of interest present.