antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-531Research ArticleОБЗОРЫREVIEWSМеханизмы нефротоксического действия иммунодепрессантов - ингибиторов кальцинейринаMechanisms of Nephrotoxic Action of Immunodepressants, Calcineurine InhibitorsНикитинА. В.NikitinA. V.noemail@neicon.ruМосковский государственный машиностроительный университет Минобрнауки РФ, МоскваРоссияState Machine Building, MoscowRussian Federation201413052020591-24447Copyright © Никитин А.В., 20202020Никитин А.В.Nikitin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/531

Внедрение в медицинскую практику иммунодепрессантов позволило успешно провести десятки тысяч операций по трансплантации печени, почек, сердца и добиться существенных успехов в лечении ряда аутоиммунных заболеваний. Применение ингибиторов кальцинейрина (циклоспорина А и такролимуса) связано с рядом побочных реакций, среди которых нефротоксичность имеет наибольшее клиническое значение. Комплексная оценка иммунологических и биохимических показателей при лечении ингибиторами кальцинейрина является важной предпосылкой повышения эффективности иммунодепрессивной терапии и снижения частоты и выраженности побочного действия препаратов.

The use of immunodepressants in the medical practice provided tens of thousands of favourable outcomes of the liver, kidney or heart transplantation and significant success in the treatment of a number of autoimmune diseases. Calcineurine inhibitors (cyclosporine A and tacrolimus) provoke a number of adverse reactions. Among them nephrotoxicity is clinically most dangerous. Complex estimation of the immunological and biochemical indices in the treatment with calcineurine inhibitors is an important precondition for increasing the efficacy of immunodepressive therapy and decreasing the frequency and level of the adverse reactions.

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The authors declare that there are no conflicts of interest present.