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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-548</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Биологически активные соединения, образуемые микроорганизмами-эндофитами</article-title><trans-title-group xml:lang="en"><trans-title>Biologically Active Compounds Produced by Microbial Endophytes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мачавариани</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Machavariani</surname><given-names>N. G.</given-names></name></name-alternatives><email xlink:type="simple">machavariani.nina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терехова</surname><given-names>Л. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Terekhova</surname><given-names>L. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт по изысканию новых антибиотиков им. Г.Ф. Гаузе РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>G.F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>59</volume><issue>5-6</issue><fpage>26</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мачавариани Н.Г., Терехова Л.П., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Мачавариани Н.Г., Терехова Л.П.</copyright-holder><copyright-holder xml:lang="en">Machavariani N.G., Terekhova L.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/548">https://www.antibiotics-chemotherapy.ru/jour/article/view/548</self-uri><abstract><p>Микроорганизмы-эвдофиты - богатый и далеко ещё не полностью изученный источник новых природных биологически активных соединений, привлекающий внимание многих ученых во всем мире. Наш обзор посвящен результатам исследования природных соединений с разнообразным биологическим действием, образуемых эндофитами.</p></abstract><trans-abstract xml:lang="en"><p>Microbial endophytes present a rich and not fully studied source of novel natural biologically active compounds of wide interest all over the world. The research of natural compounds with various biological effects produced by endophytes are described in the review.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биологически активные соединения</kwd><kwd>антибиотики</kwd><kwd>эндофиты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>biologically active compounds</kwd><kwd>antibiotics</kwd><kwd>endophytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Strobel G., Bryn Daisy B. Bioprospecting for Microbial Endophytes and Their Natural Products. Microbiol mol biol rev 2003; 67: 4: 491-502</mixed-citation><mixed-citation xml:lang="en">Strobel G., Bryn Daisy B. Bioprospecting for Microbial Endophytes and Their Natural Products. Microbiol mol biol rev 2003; 67: 4: 491-502</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Qin S. Xing K., Jiang J.-H., Xu L.-H. Li W.-J. Biodiversity, bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria. Appl Microbiol Biotechnol 2011; 89: 457-473.</mixed-citation><mixed-citation xml:lang="en">Qin S. Xing K., Jiang J.-H., Xu L.-H. Li W.-J. Biodiversity, bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria. Appl Microbiol Biotechnol 2011; 89: 457-473.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Qin S., Li J., Chen H.-H., Zhao G.-Z., Zhu W.-Y., Jiang C.-L., Xu L.- H., Li W.-L. Isolation, diversity and antimicrobial activity of rare acti-nobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China. China Appl Environ Microbiol 2009; 75: 6176-6186.</mixed-citation><mixed-citation xml:lang="en">Qin S., Li J., Chen H.-H., Zhao G.-Z., Zhu W.-Y., Jiang C.-L., Xu L.- H., Li W.-L. Isolation, diversity and antimicrobial activity of rare acti-nobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China. China Appl Environ Microbiol 2009; 75: 6176-6186.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hasegawa S., Meguro A., Shimizu M., Nishimura T., Kunoh H. Endophytic actinomycetes and their interactions with host plants. Actinomycetologica 2006; 20: 72-81.</mixed-citation><mixed-citation xml:lang="en">Hasegawa S., Meguro A., Shimizu M., Nishimura T., Kunoh H. Endophytic actinomycetes and their interactions with host plants. Actinomycetologica 2006; 20: 72-81.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H.W., Song Y.C., Tan R.X. Biology and chemistry of endophytes. Nat Prod Rep 2006; 23: 753-771.</mixed-citation><mixed-citation xml:lang="en">Zhang H.W., Song Y.C., Tan R.X. Biology and chemistry of endophytes. Nat Prod Rep 2006; 23: 753-771.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gunatilaka A.A.L. Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. J Nat Prod 2006; 69: 509-526.</mixed-citation><mixed-citation xml:lang="en">Gunatilaka A.A.L. Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. J Nat Prod 2006; 69: 509-526.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Guo B, Wang Y., Sun X., Tang K. Bioactive natural products from endophytes: a review. Appl Biochem Microbiol 2008; 44: 153-158.</mixed-citation><mixed-citation xml:lang="en">Guo B, Wang Y., Sun X., Tang K. Bioactive natural products from endophytes: a review. Appl Biochem Microbiol 2008; 44: 153-158.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Staniek A., Woerdenbag H.J., Kayser O. Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery. J Plant Interact 2008; 3: 75-93.</mixed-citation><mixed-citation xml:lang="en">Staniek A., Woerdenbag H.J., Kayser O. Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery. J Plant Interact 2008; 3: 75-93.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ryan R.P., Germaine K., Franks A., Ryan D.J., Dowling D.N. Bacterial endophytes: recent development and applications. FEMS Micribiol Lett 2008; 278: 1-9.</mixed-citation><mixed-citation xml:lang="en">Ryan R.P., Germaine K., Franks A., Ryan D.J., Dowling D.N. Bacterial endophytes: recent development and applications. FEMS Micribiol Lett 2008; 278: 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Verma V.C., Gond S.K., Kumar A., Mishra A., Kharwar R.N., Gange A.C. Endophytic actinomycetes from Azadirachta indica A. Juss: isolation, diversity, and antimicrobial activity. Microb Ecol 2009; 57: 749-756.</mixed-citation><mixed-citation xml:lang="en">Verma V.C., Gond S.K., Kumar A., Mishra A., Kharwar R.N., Gange A.C. Endophytic actinomycetes from Azadirachta indica A. Juss: isolation, diversity, and antimicrobial activity. Microb Ecol 2009; 57: 749-756.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Verma V.C., Kharwar R.N., Strobel G.A. Chemical and functional diversity of natural products from plant-associated endophytic fungi. Nat Prod Commun 2009; 11: 1511-1532.</mixed-citation><mixed-citation xml:lang="en">Verma V.C., Kharwar R.N., Strobel G.A. Chemical and functional diversity of natural products from plant-associated endophytic fungi. Nat Prod Commun 2009; 11: 1511-1532.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Araujo W.L., Marcon J., Maccheroni W.Jr., Van Elsas J.D., van Vuurde J.W.L., Azevedo J.L. Diversity of endophytic bacterial populations and their interaction with Xylella fastidiosa in citrus plants. Appl Environ Microbiol 2002; 68: 4906-4914.</mixed-citation><mixed-citation xml:lang="en">Araujo W.L., Marcon J., Maccheroni W.Jr., Van Elsas J.D., van Vuurde J.W.L., Azevedo J.L. Diversity of endophytic bacterial populations and their interaction with Xylella fastidiosa in citrus plants. Appl Environ Microbiol 2002; 68: 4906-4914.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Coombs J.T., Franco C.M.M. Isolation and identification of actinobacteria isolated from surface-sterilized wheat roots. Appl Environ Microbiol 2003; 69: 5603-5608.</mixed-citation><mixed-citation xml:lang="en">Coombs J.T., Franco C.M.M. Isolation and identification of actinobacteria isolated from surface-sterilized wheat roots. Appl Environ Microbiol 2003; 69: 5603-5608.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ryan R.P., Germaine K., Franks A., Ryan D.J., Dowling D.N. Bacterial endophytes: recent development and applications. FEMS Micribiol Lett 2008; 278: 1-9.</mixed-citation><mixed-citation xml:lang="en">Ryan R.P., Germaine K., Franks A., Ryan D.J., Dowling D.N. Bacterial endophytes: recent development and applications. FEMS Micribiol Lett 2008; 278: 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bascom-Slack C.A., Ma C., Moore E., Babbs B., Fenn K., Greene J.S., Hann B.D., Keehner J, Kelley-Swift E.G., Kembaiyan V., Lee S.J., Li P., Light D.Y., Lin E.H., Schorn M.A., Vekhter D., Boulanger L.A., Hess W.M., Vargas P.N., Strobel G.A., Strobel S.A. Multiple, novel biologically active endophytic actinomycetes isolated from upper Amazonian rainforests. Microb Ecol 2009; 58: 2: 374-383.</mixed-citation><mixed-citation xml:lang="en">Bascom-Slack C.A., Ma C., Moore E., Babbs B., Fenn K., Greene J.S., Hann B.D., Keehner J, Kelley-Swift E.G., Kembaiyan V., Lee S.J., Li P., Light D.Y., Lin E.H., Schorn M.A., Vekhter D., Boulanger L.A., Hess W.M., Vargas P.N., Strobel G.A., Strobel S.A. Multiple, novel biologically active endophytic actinomycetes isolated from upper Amazonian rainforests. Microb Ecol 2009; 58: 2: 374-383.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Strobel, G.A., Miller R.V., Miller C., Condron M., Teplow D.B., Hess W.M. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology 1999; 145: 1919-1926.</mixed-citation><mixed-citation xml:lang="en">Strobel, G.A., Miller R.V., Miller C., Condron M., Teplow D.B., Hess W.M. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology 1999; 145: 1919-1926.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li J.Y., Strobel G.A., Harper J.K., Lobkovsky E., Clardy J. Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett 2000; 2: 767-770.</mixed-citation><mixed-citation xml:lang="en">Li J.Y., Strobel G.A., Harper J.K., Lobkovsky E., Clardy J. Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett 2000; 2: 767-770.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J.C., Yang X., Schwartz M., Strobel G., Clardy J. The relationship between an endangered North American tree and an endophytic fungus. Chem. Biol 1995; 2: 721-727.</mixed-citation><mixed-citation xml:lang="en">Lee J.C., Yang X., Schwartz M., Strobel G., Clardy J. The relationship between an endangered North American tree and an endophytic fungus. Chem. Biol 1995; 2: 721-727.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pulici M., Sugawara F., Koshino H., Uzawa J., Yoshida S., Lobkovsky E., Clardy J. Pestalotiopsin-A and pestalotiopsin-B: new caryophyl-lenes from an endophytic fungus of Taxus brevifolia. J Org Chem 1996; 61: 2122-2124.</mixed-citation><mixed-citation xml:lang="en">Pulici M., Sugawara F., Koshino H., Uzawa J., Yoshida S., Lobkovsky E., Clardy J. Pestalotiopsin-A and pestalotiopsin-B: new caryophyl-lenes from an endophytic fungus of Taxus brevifolia. J Org Chem 1996; 61: 2122-2124.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Zou W.X.T., Meng J.C., Lu H., Chen G.X., Shi G.X., Zhang T.Y., Tan R.X. Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. J. Nat. Prod., 2000, 63:1529-1530</mixed-citation><mixed-citation xml:lang="en">Zou W.X.T., Meng J.C., Lu H., Chen G.X., Shi G.X., Zhang T.Y., Tan R.X. Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. J. Nat. Prod., 2000, 63:1529-1530</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Hao F., Liu N., Xu Y., Jia A., Yang Z., Xia X., Liu C. Stereochemical determination of a new and cytotoxic euphane triterpenoid from the plant endophytic fungus Phimopsis chimonanthi. J Antibiot 07/08/2013. (doi:10.1038/ja.2013.70).</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Hao F., Liu N., Xu Y., Jia A., Yang Z., Xia X., Liu C. Stereochemical determination of a new and cytotoxic euphane triterpenoid from the plant endophytic fungus Phimopsis chimonanthi. J Antibiot 07/08/2013. (doi:10.1038/ja.2013.70).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Horn W.S., Simmonds M.S.J., Schwartz R.E., Blaney W.M. Phomopsichalasin, a novel antimicrobial agent from an endophytic Phomopsis sp. Tetrahedron 1995; 14: 3969-3978.</mixed-citation><mixed-citation xml:lang="en">Horn W.S., Simmonds M.S.J., Schwartz R.E., Blaney W.M. Phomopsichalasin, a novel antimicrobial agent from an endophytic Phomopsis sp. Tetrahedron 1995; 14: 3969-3978.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Shiono Y., Nitto A., Shimanuki K., Koseki T., Murayama T., Miyakawa T., Yoshida J., Kimura K. A new benzoxepin metabolite isolated from endophytic fungus Phomopsis sp., a new benzoxepin metabolite. J Antibiot 2009; 62: 533-535.</mixed-citation><mixed-citation xml:lang="en">Shiono Y., Nitto A., Shimanuki K., Koseki T., Murayama T., Miyakawa T., Yoshida J., Kimura K. A new benzoxepin metabolite isolated from endophytic fungus Phomopsis sp., a new benzoxepin metabolite. J Antibiot 2009; 62: 533-535.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wagenaar M.M., Clardy J. Dicerandrols, new antibiotic and cytotoxic dimmers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod 2001; 64: 8: 1006-1009.</mixed-citation><mixed-citation xml:lang="en">Wagenaar M.M., Clardy J. Dicerandrols, new antibiotic and cytotoxic dimmers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod 2001; 64: 8: 1006-1009.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Chaesung L., Kim J., Choi J.N., Ponnusamy K., Jeon Y., Kim S.-U., Kim J.G., Hwan Lee C.H. Identification, fermentation, and bioactivity against Xanthomonas oryzae of antimicrobial metabolites isolated from Phomopsis longicolla S1B4. J Microbiol Biotechnol 2010; 20: 3: 494-500.</mixed-citation><mixed-citation xml:lang="en">Chaesung L., Kim J., Choi J.N., Ponnusamy K., Jeon Y., Kim S.-U., Kim J.G., Hwan Lee C.H. Identification, fermentation, and bioactivity against Xanthomonas oryzae of antimicrobial metabolites isolated from Phomopsis longicolla S1B4. J Microbiol Biotechnol 2010; 20: 3: 494-500.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Choi J.N., Kim J., Ponnusamy K., Lim C., Kim J.G., Muthaiya M.J., Lee C.H. Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during fermentation. J Antibiot 2013; 66: 231-233.</mixed-citation><mixed-citation xml:lang="en">Choi J.N., Kim J., Ponnusamy K., Lim C., Kim J.G., Muthaiya M.J., Lee C.H. Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during fermentation. J Antibiot 2013; 66: 231-233.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Weber D., Erosa G., Sterner O., Anke T. Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp. J Antibiot 2006; 59: 8: 495-499.</mixed-citation><mixed-citation xml:lang="en">Weber D., Erosa G., Sterner O., Anke T. Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp. J Antibiot 2006; 59: 8: 495-499.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Verma V.C., Lobkovsky E., Gange A.C., Singh S.K., Prakash S. Piperine production by endophytic fungus Periconia sp. isolated from Piper longum L. J Antibiot 2011; 64: 427-431.</mixed-citation><mixed-citation xml:lang="en">Verma V.C., Lobkovsky E., Gange A.C., Singh S.K., Prakash S. Piperine production by endophytic fungus Periconia sp. isolated from Piper longum L. J Antibiot 2011; 64: 427-431.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Moreno E., Varughese T., Spadafora C., Arnold A.E., Coley P.D., Kursar T.A., Gerwick W.H., Cubilla-Rios L. Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. 2011; 6: 6: 835-840.</mixed-citation><mixed-citation xml:lang="en">Moreno E., Varughese T., Spadafora C., Arnold A.E., Coley P.D., Kursar T.A., Gerwick W.H., Cubilla-Rios L. Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. 2011; 6: 6: 835-840.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ding G., Qi Y., Liu S., Guo L., Chen X. Photipyrones A and B, new pyrone derivatives from the plant fungus Pestalotiopsis photiniae. J Antibiot 2012; 65; 271-273.</mixed-citation><mixed-citation xml:lang="en">Ding G., Qi Y., Liu S., Guo L., Chen X. Photipyrones A and B, new pyrone derivatives from the plant fungus Pestalotiopsis photiniae. J Antibiot 2012; 65; 271-273.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ding G., Wang H.-L., Chen L., Chen A.-J., Lan J., Chen X.-D., Zhang H.-W., Chen H., Liu X.-Z., Zou Z.-M. Cytochalasans with different amino-acid origin from the plant endophytic fungus Trichoderma gamsii. J Antibiot 2012; 65: 143-145.</mixed-citation><mixed-citation xml:lang="en">Ding G., Wang H.-L., Chen L., Chen A.-J., Lan J., Chen X.-D., Zhang H.-W., Chen H., Liu X.-Z., Zou Z.-M. Cytochalasans with different amino-acid origin from the plant endophytic fungus Trichoderma gamsii. J Antibiot 2012; 65: 143-145.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Guo B., Dai J.-R., Ng S., Huang Y., Leong C., Ong W., Cart'e B.K. Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema Species. J Nat Prod 2000; 63: 5: 602-604.</mixed-citation><mixed-citation xml:lang="en">Guo B., Dai J.-R., Ng S., Huang Y., Leong C., Ong W., Cart'e B.K. Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema Species. J Nat Prod 2000; 63: 5: 602-604.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ballio A., Bossa F., DiGiogio P., Ferranti P., Paci M., Pucci P., Scaloni A., Segre A., Strobel G.A. Structure of the pseudomycins, new lipodepsipeptides produced by Pseudomonas syringae MSU 16H. FEBS Lett 1994; 355: 96-100.</mixed-citation><mixed-citation xml:lang="en">Ballio A., Bossa F., DiGiogio P., Ferranti P., Paci M., Pucci P., Scaloni A., Segre A., Strobel G.A. Structure of the pseudomycins, new lipodepsipeptides produced by Pseudomonas syringae MSU 16H. FEBS Lett 1994; 355: 96-100.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Harrison L., Teplow D., Rinaldi M., Strobel G.A. Pseudomycins, a family of novel peptides from Pseudomonas syringae, possessing broad spectrum antifungal activity. J Gen Microbiol 1991; 137: 2857-2865.</mixed-citation><mixed-citation xml:lang="en">Harrison L., Teplow D., Rinaldi M., Strobel G.A. Pseudomycins, a family of novel peptides from Pseudomonas syringae, possessing broad spectrum antifungal activity. J Gen Microbiol 1991; 137: 2857-2865.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Miller R.V., Miller C.M., Garton-Kinney D., Redgrave B., Sears J., Condron M., Teplow D., Strobel G.A. Ecomycins, unique antimycotics from Pseudomonas viridiflava. J Appl Microbiol 1998; 84: 937-944.</mixed-citation><mixed-citation xml:lang="en">Miller R.V., Miller C.M., Garton-Kinney D., Redgrave B., Sears J., Condron M., Teplow D., Strobel G.A. Ecomycins, unique antimycotics from Pseudomonas viridiflava. J Appl Microbiol 1998; 84: 937-944.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Castillo U.F., Strobel G.A., Ford E.J., Hess W.M., Porter H., Jensen J.B., Albert H., Robison R., Condron M.A.M., Teplow D.B., Stevens D., Yaver D. Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans. Microbiology 2002; 148: 2675-2685.</mixed-citation><mixed-citation xml:lang="en">Castillo U.F., Strobel G.A., Ford E.J., Hess W.M., Porter H., Jensen J.B., Albert H., Robison R., Condron M.A.M., Teplow D.B., Stevens D., Yaver D. Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans. Microbiology 2002; 148: 2675-2685.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Castillo U.F., Strobel G.A., Mullenberg K., Condron M.M., Teplow D.B., Folgiano V., Gallo M., Ferracane R., Mannina L., Viel S., Codde M., Robison R., Porter H., Jensen J. Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL3052. FEMS Microbiol Lett 2006; 255: 296-300.</mixed-citation><mixed-citation xml:lang="en">Castillo U.F., Strobel G.A., Mullenberg K., Condron M.M., Teplow D.B., Folgiano V., Gallo M., Ferracane R., Mannina L., Viel S., Codde M., Robison R., Porter H., Jensen J. Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL3052. FEMS Microbiol Lett 2006; 255: 296-300.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Christina A., Christapher V., Bhore S.J. Endophytic bacteria as a source of novel antibiotics: an overview. Phcog Rev 2013; 7: 11-16.</mixed-citation><mixed-citation xml:lang="en">Christina A., Christapher V., Bhore S.J. Endophytic bacteria as a source of novel antibiotics: an overview. Phcog Rev 2013; 7: 11-16.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Castillo U., Harper J.K., Strobel G.A., Sears J., Alesi K., Ford E., Lin J., Hunter M., Maranta M., Ge H., Yaver D., Jensen J.B., Porter H., Robison R., Miller D., Hess W.M., Condron M., Teplow D. Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of Grevillea pteridifolia. FEMS Microbiol Lett 2003; 234: 183-190.</mixed-citation><mixed-citation xml:lang="en">Castillo U., Harper J.K., Strobel G.A., Sears J., Alesi K., Ford E., Lin J., Hunter M., Maranta M., Ge H., Yaver D., Jensen J.B., Porter H., Robison R., Miller D., Hess W.M., Condron M., Teplow D. Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of Grevillea pteridifolia. FEMS Microbiol Lett 2003; 234: 183-190.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ezra D., Castillo U.F., Strobel G.A., Hess W.M., Porter H., Jensen J.B., Condron M.A.M., Teplow D.B., Sears J., Maranta M., Hunter M., Weber B., Yaver D. Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. Microbiology 2004; 150: 785-793.</mixed-citation><mixed-citation xml:lang="en">Ezra D., Castillo U.F., Strobel G.A., Hess W.M., Porter H., Jensen J.B., Condron M.A.M., Teplow D.B., Sears J., Maranta M., Hunter M., Weber B., Yaver D. Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. Microbiology 2004; 150: 785-793.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">El-Gendy M.M.A., EL-Bondkly A.M.A. Production and genetic improvement of a novel antimycotic agent, saadamycin, against dermatophytes and other clinical fungi from endophytic Streptomyces sp. Hedaya48. J Ind Microbiol Biotechnol 2010; 37: 8: 831-841.</mixed-citation><mixed-citation xml:lang="en">El-Gendy M.M.A., EL-Bondkly A.M.A. Production and genetic improvement of a novel antimycotic agent, saadamycin, against dermatophytes and other clinical fungi from endophytic Streptomyces sp. Hedaya48. J Ind Microbiol Biotechnol 2010; 37: 8: 831-841.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ding L., Muenich J., Goerls H., Maier A., Fiebig H.-H., Lin W.-H., Hertweck C. Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorgan Med Chem Let 2010; 20: 22: 6685-6687.</mixed-citation><mixed-citation xml:lang="en">Ding L., Muenich J., Goerls H., Maier A., Fiebig H.-H., Lin W.-H., Hertweck C. Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorgan Med Chem Let 2010; 20: 22: 6685-6687.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Taechowisan T., Wanbanjob A., Tuntiwachwuttikul P., Taylor W.C. Identification of Streptomyces sp. Tc022, an endophyte in Alpinia galanga, and the isolation of actinomycin D. Ann Microbiol 2006; 56: 2: 113-117.</mixed-citation><mixed-citation xml:lang="en">Taechowisan T., Wanbanjob A., Tuntiwachwuttikul P., Taylor W.C. Identification of Streptomyces sp. Tc022, an endophyte in Alpinia galanga, and the isolation of actinomycin D. Ann Microbiol 2006; 56: 2: 113-117.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tuntiwachwuttikul P., Taechowisan T., Wanbanjob A., Thadaniti S., Taylor W.C. Lansai A-D, secondary metabolites from Streptomyces sp. SUC1. Tetrahedron 2008; 64: 7583-7586.</mixed-citation><mixed-citation xml:lang="en">Tuntiwachwuttikul P., Taechowisan T., Wanbanjob A., Thadaniti S., Taylor W.C. Lansai A-D, secondary metabolites from Streptomyces sp. SUC1. Tetrahedron 2008; 64: 7583-7586.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Taechowisana T., Wanbanjob A., Tuntiwachwuttikul P., Liu J.K. Antiinflammatory activity of lansais from endophytic Streptomyces sp. SUC1 in LPS-induced RAW 264.7 cells. Food Agric Immunol 2009; 20: 67-77.</mixed-citation><mixed-citation xml:lang="en">Taechowisana T., Wanbanjob A., Tuntiwachwuttikul P., Liu J.K. Antiinflammatory activity of lansais from endophytic Streptomyces sp. SUC1 in LPS-induced RAW 264.7 cells. Food Agric Immunol 2009; 20: 67-77.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Tuntiwachwuttikul P., Taechowisan T., Wanbanjob A., Thadaniti S., Taylor W.C. Lansai A-D, secondary metabolites from Streptomyces sp. SUC1. Tetrahedron 2008; 64: 7583-7586.</mixed-citation><mixed-citation xml:lang="en">Tuntiwachwuttikul P., Taechowisan T., Wanbanjob A., Thadaniti S., Taylor W.C. Lansai A-D, secondary metabolites from Streptomyces sp. SUC1. Tetrahedron 2008; 64: 7583-7586.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Schreiber D., Jung M., Sandjo L.P., Liermann J.C., Opatz T., Erkel G. 3’-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammotory diaryl ethers from a Steganospora species. J Antibiot 2012; 65: 473-477.</mixed-citation><mixed-citation xml:lang="en">Schreiber D., Jung M., Sandjo L.P., Liermann J.C., Opatz T., Erkel G. 3’-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammotory diaryl ethers from a Steganospora species. J Antibiot 2012; 65: 473-477.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Lu C.H., Shen Y.M. A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. J Antibiot 2003; 56: 415-418.</mixed-citation><mixed-citation xml:lang="en">Lu C.H., Shen Y.M. A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. J Antibiot 2003; 56: 415-418.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Lu C.H., Shen Y.M. Two new macrolides produced by Streptomyces sp. CS. J Antibiot 2004; 57: 597-600.</mixed-citation><mixed-citation xml:lang="en">Lu C.H., Shen Y.M. Two new macrolides produced by Streptomyces sp. CS. J Antibiot 2004; 57: 597-600.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lu C.H., Shen Y.M. A novel ansamycin, naphthomycin K from Streptomyces sp. J Antibiot 2007; 60: 649-653.</mixed-citation><mixed-citation xml:lang="en">Lu C.H., Shen Y.M. A novel ansamycin, naphthomycin K from Streptomyces sp. J Antibiot 2007; 60: 649-653.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao P.J., Fan L.M., Li G.H., Zhu N., Shen Y.M. Antibacterial and antitumor macrolides from Streptomyces sp. ls9131. Arch Pharm Res 2005; 28: 1228-1232.</mixed-citation><mixed-citation xml:lang="en">Zhao P.J., Fan L.M., Li G.H., Zhu N., Shen Y.M. Antibacterial and antitumor macrolides from Streptomyces sp. ls9131. Arch Pharm Res 2005; 28: 1228-1232.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Li J., Lu C.H., Shen Y.M. Macrolides of the bafilomycin family produced by Streptomyces sp. CS. J Antibiot 2010; 63: 10: 595-599.</mixed-citation><mixed-citation xml:lang="en">Li J., Lu C.H., Shen Y.M. Macrolides of the bafilomycin family produced by Streptomyces sp. CS. J Antibiot 2010; 63: 10: 595-599.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Yu Z., Zhao L.-X., Jiang C.L., Duan Y., Wong L., Carver K.C., Shuler L.A., Shen B. Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. J Antibiot 2011; 64: 159-162.</mixed-citation><mixed-citation xml:lang="en">Yu Z., Zhao L.-X., Jiang C.L., Duan Y., Wong L., Carver K.C., Shuler L.A., Shen B. Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. J Antibiot 2011; 64: 159-162.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Taechowisan T., Lu C., Shen Y., Lumyong S. Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity. Microbiology 2005; 151: 1691-1695.</mixed-citation><mixed-citation xml:lang="en">Taechowisan T., Lu C., Shen Y., Lumyong S. Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity. Microbiology 2005; 151: 1691-1695.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Taechowisan T., Lu C.H., Shen Y.M., Lumyong S. 4-Arylcoumarin inhibits immediate-type allergy. Food Agric Immunol 2007; 18: 203-211.</mixed-citation><mixed-citation xml:lang="en">Taechowisan T., Lu C.H., Shen Y.M., Lumyong S. 4-Arylcoumarin inhibits immediate-type allergy. Food Agric Immunol 2007; 18: 203-211.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Taechowisan T., Lu C.H., Shen Y.M., Lumyong S. Antitumor activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130. J Cancer Res Trer 2007; 3: 86-91.</mixed-citation><mixed-citation xml:lang="en">Taechowisan T., Lu C.H., Shen Y.M., Lumyong S. Antitumor activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130. J Cancer Res Trer 2007; 3: 86-91.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Kim N., Shin J.C., Kim W., Hwang B.Y., Kim B.S., Hong Y.S., Lee D. Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. J Antibiot 2006; 59: 797-800.</mixed-citation><mixed-citation xml:lang="en">Kim N., Shin J.C., Kim W., Hwang B.Y., Kim B.S., Hong Y.S., Lee D. Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. J Antibiot 2006; 59: 797-800.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Igarashi Y., Miura S., Fujita T., Furumai T. Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus. J Antibiot 2006; 59: 193-195.</mixed-citation><mixed-citation xml:lang="en">Igarashi Y., Miura S., Fujita T., Furumai T. Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus. J Antibiot 2006; 59: 193-195.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Huang S.-X., Yu Z., Robert F., Zhao L.-X., Jiang Y., Duan Y., Pelletier J., Shen B. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. J Antibiot 2011; 64: 163-166.</mixed-citation><mixed-citation xml:lang="en">Huang S.-X., Yu Z., Robert F., Zhao L.-X., Jiang Y., Duan Y., Pelletier J., Shen B. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. J Antibiot 2011; 64: 163-166.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
