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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-572</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Исследование антимикоплазменной активности культуральной жидкости Trichoderma harzianum Rifai F-180 - продуцента противоопухолевого и антивирусного фермента L-лизин-а-оксидазы</article-title><trans-title-group xml:lang="en"><trans-title>Antimycoplasmic Activity of Fermentation Broth of Trichoderma harzianum Rifai F-180, an Organism Producing L-Lysine-a-Oxidase, an Antitumor and Antiviral Enzyme</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>I. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ваковская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakovskaya</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский университет дружбы народов<country>Россия</country></aff><aff xml:lang="en">Russian University of Peoples' Friendship<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ НИИЭМ им. Н. Ф. Гамалеи<country>Россия</country></aff><aff xml:lang="en">N. F. Gamaleya Research Institute of Epidemiology and Microbiology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>05</month><year>2020</year></pub-date><volume>59</volume><issue>11-12</issue><fpage>7</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова И.П., Ваковская И.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Смирнова И.П., Ваковская И.В.</copyright-holder><copyright-holder xml:lang="en">Smirnova I.P., Rakovskaya I.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/572">https://www.antibiotics-chemotherapy.ru/jour/article/view/572</self-uri><abstract><p>Получен концентрат культуральной жидкости Trichoderma harzianum Rifai F-180 - продуцента противоопухолевого и антивирусного фермента L-лизин-α-оксвдазы с активностью в культуральной жидкости 0,54-0,56 Ед/мл. Впервые исследовано влияние полученного концентрата на рост микоплазм: двух видов представителей семейства Мycoplasmataceae: Mycoplasma hominis и Mycoplasma fermentans и одного вида представителя семейства Aholeplasmataceae: Aholeplasma laidlawii. Показано, что культуральная жидкость Trichoderma harzianum Rifai F-180 - продуцента противоопухолевого и антивирусного фермента L-лизин-α-оксидазы ингибирует рост Mycoplasma hominis после предварительного контакта. Степень подавления роста зависит от посевной дозы микоплазмы и исследованной концентрации культуральной жидкости триходермы.</p></abstract><trans-abstract xml:lang="en"><p>A concentrate of the fermentation broth of Trichoderma harzianum Rifai F-180, an organism producing L-lysine-α-oxidase, an antitumor and antiviral enzyme, with the activity in the fermentation broth of 0.54-0.56 U/ml was recovered. The effect of the concentrate on the mycoplasmas growth was investigated for the first time. Two representatives of Mycoplasmafaceae, i.e. Mycoplasma hominis and Mycoplasma fermentans and one representative of Aholeplasmataceae. i. e. Aholeplasma laidlawii were used. It was shown that the fermentation broth inhibited the growth of Mycoplasma hominis after the preliminary exposure. The inhibition rate depended on the mycoplasma inoculation dose and the fermentation broth concentration.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>триходерма</kwd><kwd>микоплазмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>L-лизин-α-оксидаза</kwd><kwd>L-lysine-α-oxidase</kwd><kwd>trichoderma</kwd><kwd>mycoplasmas</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Раковская И.В. Микоплазмы-возбудители микоплазменных инфекций человека. В кн. Руководство по медицинской микробиологии / Под ред. А.С. Лабинской и др. 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Биологическая и биохимическая стабильность метаболитов сапрофитного гриба</mixed-citation><mixed-citation xml:lang="en">Пакина Е.В., Шнейдер Ю.А., Смирнова И.П. Биологическая и биохимическая стабильность метаболитов сапрофитного гриба</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
