antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-594Research ArticleСтатьиМорские бурые водоросли - источник новых фармацевтических субстанций антибактериальной направленностиBrown Seaweeds as a Source of New Pharmaceutical Substances with Antibacterial ActionБеседноваH. H.BesednovaN. N.noemail@neicon.ruКузнецоваТ. А.KuznetsovaT. A.noemail@neicon.ruЗапорожецТ. С.ZaporozhetsT. S.noemail@neicon.ruЗвягинцеваТ. Н.ZvyagintsevaT. N.noemail@neicon.ruФГБУ НИИ эпидемиологии и микробиологии им. Г.П. СомоваРоссияG.P. Somov Research Institute of Epidemiology and MicrobiologyRussian FederationФГБУН Тихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАНРоссияG.B. Elyakov Pacific Institute of Bioorganic ChemistryRussian Federation201513052020603-43141Copyright © Беседнова H.H., Кузнецова Т.А., Запорожец Т.С., Звягинцева Т.Н., 20202020Беседнова H.H., Кузнецова Т.А., Запорожец Т.С., Звягинцева Т.Н.Besednova N.N., Kuznetsova T.A., Zaporozhets T.S., Zvyagintseva T.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/594

В настоящее время рост антибиотикорезистентности возбудителей инфекционных болезней к противомикробным препаратам обусловливает необходимость поиска новых антимикробных субстанций с улучшенными фармакологическими свойствами и новыми механизмами действия, к которым у микроорганизмов не формируется устойчивость. Такой поиск идет по трём направлениям: выделение новых веществ из природных объектов, в том числе из гидробионтов; химическая модификация молекул известных антибиотиков; поиск соединений с антимикробной активностью из числа новых химических структур, не имеющих аналогов в живой природе. Настоящий обзор посвящён антибактериальной, антивирусной и антигрибковой активности сульфатированных полисахаридов (фукоиданов) и экстрактов бурых, красных и зелёных морских водорослей, а также антиоксидантным, противовоспалительным, иммуномодулирующим и антиэндотоксическим свойствам, способствующим усилению их антиинфекционного действия. С учётом этой активности фукоиданы являются перспективной основой для создания новых препаратов для лечения инфекционных заболеваний.

At present the increase of antibiotic resistance in infection agents to antimicrobial drugs requires discovery of new antimicrobial substances with improved pharmacological properties and novel mechanisms of action, to which microorganisms do not develop resistance. Three areas are of interest for the search: recovery of new compounds from natural objects, including aquatic organisms, chemical modification of the known antibiotic molecules, discovery of compounds with antimicrobial activity among some new chemical structures which have no analogues in nature. The review is mainly concerned with discussion of antibacterial, antiviral and antifungal activity of sulfated polysaccharides (fucoidans) and extracts of brown, red and green algae, as well as of antioxidant, antiinflammatory, immunomodulatory and antiendotoxin properties that contribute to their antiinfective action. Such an activity makes fucoidans promising as a basis for developing new drugs for therapy of infectious diseases.

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The authors declare that there are no conflicts of interest present.