antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-620Research ArticleОБЗОРЫREVIEWSБиологические функции сукцината (обзор зарубежных экспериментальных исследований)Biological Functions of Succinate (a Review of Foreign Experimental Studies)ВалеевВ. В.ValeevV. V.noemail@neicon.ruКоваленкоА. Л.KovalenkoA. L.noemail@neicon.ruТаликоваЕ. В.TalikovaE. V.noemail@neicon.ruЗаплутановВ. А.ZaplutanovV. A.noemail@neicon.ruДельвиг-КаменскаяТ. Ю.Delvig-KamenskayaT. Yu.noemail@neicon.ruНаучно-технологическая фармацевтическая фирма «ПОЛИСАН»РоссияScientific and Technological Pharmaceutical Firm «POLYSAN»Russian FederationИнститут токсикологии Федерального медико-биологического агентстваРоссияInstitute of Toxicology, Federal Medico-Biological AgencyRussian FederationСанкт-Петербургский медико-социальный институтРоссияSankt-Petersburg Medical-Social InstituteRussian FederationСанкт-Петербургская государственная химико-фармацевтическая академияРоссияSankt-Petersburg State Chemico-Pharmaceutical AcademyRussian Federation201513052020609-103337Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/620

Проведён анализ зарубежных научных публикаций, отражающих современные представления о биологической роли сукцината - интермедиата цикла трикарбоновых кислот. Интерес зарубежных исследователей к сукцинату связан с изучением работы митохондрий при различных патофизиологических состояниях, открытием гипоксия-индуцибельного фактора HIF-1, а также с исследованиями генома человека, благодаря которым были обнаружены G-протеин-зависимые рецепторы, избирательно связывающиеся с сукцинатом. Согласно результатам зарубежных экспериментальных работ, помимо участия в реакциях биологического окисления, сукцинат играет важную роль в регуляции физиологических, метаболических и генетических процессов.

The published data on the modern concept of the biological role of succinate, an intermediate of the citric acid cycle are analysed in the review. Special interest to succinate is determined by investigations on the mitochondrial functions at different pathologies, discovery of the hypoxia-inducible factor HIF-1 and studies on the human genome, that resulted in detection of the G-protein coupled receptors, which selectively are bound with succinate. According to the published experimental data, besides participation in oxidative reactions, succinate is considered as a key contributor to physiological, metabolic and genetic processes.

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The authors declare that there are no conflicts of interest present.