antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-66Research ArticleВ ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУGUIDELINES FOR PRACTITIONERSПотенциальные возможности мониторинга концентрации прокальцитонина при проведении антибактериальной терапии инфекций нижних дыхательных путейPotential Possibilities of Monitoring the Procalcitonin Concentration During Antibacterial Therapy of Lower Respiratory Tract InfectionsЛазареваН. Б.LazarevaN. B.natalia.lazareva@gmail.comЖуравлеваМ. В.ZhuravlevaM. V.noemail@neicon.ruПрокофъевА. Б.ProkofievA. B.noemail@neicon.ruШихЕ. В.ShikhE. V.noemail@neicon.ruПервый Московский медицинский университет им. И. М. Сеченова Минздрава РоссииРоссияI. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian FederationЦентр клинической фармакологии ФГБУ Научный центр экспертизы средств медицинского применения Минздрава РоссииРоссияScientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian FederationRussian Federation201806052020631-23237Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/66

Растущий уровень резистентности микроорганизмов требует критического снижения случаев необоснованного применения антибиотиков и сокращения общей продолжительности антибактериальной терапии. Контролируемые клинические исследования, проведённые в последние годы, подтвердили высокую эффективность использования теста на прокальцитонин (B-R-A-H-M-S PCT™) в отношении уменьшения случаев необоснованного назначения и сокращения сроков проведения антибактериальной терапии. В этой связи тест на прокальцитонин способствует персонализации подходов к проведению антибактериальной терапии. Благодаря определению уровня прокальцитонина (B-R-A-H-M-S PCT™) возможно добиться существенного снижения частоты проведения эмпирической антибактериальной терапии в ситуациях низкого риска (бронхиты, обострения ХОБЛ). В более тяжёлых клинических ситуациях (пневмония, сепсис) мониторинг концентрации прокальцитонина позволяет сократить сроки проведения антибактериальной терапии.

The growing level of resistance of microorganisms requires a critical reduction in cases of unreasonable use of antibiotics and a reduction in the overall duration of antibiotic therapy. Controlled clinical trials conducted in recent years have confirmed the high effectiveness of the use of the procalcitonin test (B-R-A-H-M-S PCT™) in reducing the occurrence of unjustified prescribing of antibiotic therapy and reducing its duration.In this regard, procalcitonin test promotes the personalization of approaches to antibiotic therapy. It is possible to significantly reduce the frequency of empirical antibiotic therapy in low-risk situations (bronchitis, exacerbation of COPD) by determining the level of procalcitonin (B-R-A-H-M-S PCT™). Monitoring the concentration of procalcitonin allows shortening of the duration of antibiotic therapy in more severe clinical situations (pneumonia, sepsis).

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The authors declare that there are no conflicts of interest present.