antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-664Research ArticleОБЗОРЫREVIEWSНовые данные о молекулярных мишенях тамоксифена, отличных от рецепторов эстрогенов, и их клиническая значимостьNew Data on Molecular Targets of Tamoxifen Besides Estrogen Receptors, Their Clinical SignificancyБогушТ. А.BogushT. A.bogush@orc.ruПолежаевБ. Б.PolezhaevB. B.noemail@neicon.ruДудкоЕ. А.DudkoE. A.noemail@neicon.ruБогушЕ. А.BogushE. A.noemail@neicon.ruКирсановВ. Ю.KirsanovV. Yu.noemail@neicon.ruПолоцкийБ. Е.PolotskyB. E.noemail@neicon.ruТюляндинС. А.TjuljandinS. A.noemail@neicon.ruДавыдовМ. И.DavydovM. I.noemail@neicon.ruФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава РоссииРоссияN. N. Blokhin Russian Cancer Research CenterRussian FederationФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава РоссииРоссияM. V. Lomonosov Moscow State UniversityRussian Federation201613052020613-44149Copyright © Богуш Т.А., Полежаев Б.Б., Дудко Е.А., Богуш Е.А., Кирсанов В.Ю., Полоцкий Б.Е., Тюляндин С.А., Давыдов М.И., 20202020Богуш Т.А., Полежаев Б.Б., Дудко Е.А., Богуш Е.А., Кирсанов В.Ю., Полоцкий Б.Е., Тюляндин С.А., Давыдов М.И.Bogush T.A., Polezhaev B.B., Dudko E.A., Bogush E.A., Kirsanov V.Y., Polotsky B.E., Tjuljandin S.A., Davydov M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/664

Тамоксифен - первый таргетный препарат, который по-прежнему занимает лидирующую позицию в лечении рака молочной железы. Экспериментальные работы последних лет раскрывают всё новые и новые биологические эффекты при воздействии тамоксифена на опухолевые клетки. Данная публикация является продолжением опубликованного в 2012 г. обзора данных литературы, демонстрирующих многообразие эффектов тамоксифена, не связанных с его взаимодействием с рецепторами эстрогенов. Так, выявлен обширный спектр мишеней препарата, которые являются ключевыми точками сигнальных каскадов, активирующих пролиферацию клеток, определяют агрессивность течения опухолевого процесса и чувствительность к химиотерапии. Описаны клинические исследования применения тамоксифена, основанием для которых явилось воздействие препарата на мишени, отличные от рецепторов эстрогенов. Кроме того, в обзор включены данные о противовирусной, противобактериальной, противогрибковой и противопаразитарной активности тамоксифена.

Tamoxifen is the first target agent with a high-end position in breast cancer therapy till now. In recent years experimental researches revealed new biological effects of tamoxifen on tumor cells. The present study continues the theme of the review published in 2012, where a plenty of tamoxifen effects besides interaction with estrogen receptors was discussed. Thus, there is described a wide range of the drug targets which are the key points of signal cascades activating the cell proliferation and determining the course of the growth of the cancer and its sensitivity to chemotherapy. Also clinical trials of tamoxifen based on existing of targets besides the estrogen receptors are reviewed. Furthermore, the data on the antiviral, antibacterial, antifungal and antiparasitic activities of tamoxifen are indicated.

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The authors declare that there are no conflicts of interest present.