antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-668Research ArticleОБЗОРЫREVIEWSАнтиоксиданты как потенциальные противовирусные препараты при флавивирусных инфекцияхAntioxidants as Potential Antiviral Agents for Flavivirus InfectionsКрыловаН. В.KrylovaN. V.krylovanatalya@gmail.comПоповА. М.PopovA. M.noemail@neicon.ruЛеоноваГ. Н.LeonovaG. N.noemail@neicon.ruНИИ эпидемиологии и микробиологии им. Г. П. СомоваРоссияG. P. Somov Research Institute of Epidemiology and MicrobiologyRussian FederationТихоокеанский институт биоорганической химии им. Г. Б. Елякова, Дальневосточное отделение РАН; Дальневосточный Федеральный УниверситетРоссияG. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences; Far Eastern Federal UniversityRussian Federation201613052020615-62531Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/668

В обзоре рассматриваются потенциальные возможности определённых антиоксидантов как противовирусных агентов при флавивирусных инфекциях. В настоящее время флавивирусные инфекции представляют существенную проблему для здравоохранения в различных частях мира, поскольку приводят к высокой заболеваемости и летальным исходам. Окислительный стресс, индуцированный вирусами, в том числе и флавивирусами, включает не только вмешательство в ведущие метаболические процессы организма, но и регулирует репликацию вируса. Показан широкий спектр противовирусной активности природных фенольных антиоксидантов - розмариновой кислоты и лютеолина - компонентов полифенольного комплекса, выделенного из морских трав семейства Zosteraceae. Противовирусная активность розмариновой кислоты и лютеолина обусловлена их высоким антиоксидантным, противовоспалительным и нейропротективным потенциалом. Особое внимание уделено анализу активности полифенольного комплекса и его компонентов в отношении вируса клещевого энцефалита (КЭ). Противовирусные свойства этих соединений, обладающих широким спектром биологического действия, позволяют рассматривать их как перспективных кандидатов для комплексной терапии КЭ.

The review considers potential opportunities of certain antioxidants as antiviral agents for flavivirus infections. Currently flavivirus infections represent a significant public health problem for various regions of the world, since they result in high morbidity and mortality. Oxidative stress induced by viruses, including the flaviviruses, not only interferes with the body's important metabolic processes, but also regulates replication of the virus. A broad spectrum of antiviral activity of the natural phenolic antioxidants, i.e. rosmarinic acid and luteolin as components of the polyphenol complex isolated from the seagrass family Zosteraceae is decribed. The antiviral activity of rosmarinic acid and luteolin is shown to be due to their high antioxidant, antiinflammatory and neuroprotective potential. Particular attention is paid to the analysis of the activity of the polyphenol complex and its components against the tick-borne encephalitis virus. The antiviral properties of the compounds with a broad spectrum of the biological action provide an opportunity to consider them as promising candidates for combined therapy of tick-borne encephalitis.

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The authors declare that there are no conflicts of interest present.