antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2020-65-3-4-39-44antibiotics-721Research ArticleОБЗОРЫREVIEWSАнтибактериальная терапия туляремии: современное состояние и перспективыAntibacterial Therapy of Tularemia: Current Status and ProspectsЩипелеваИ. А.ShchipelevaI. A.

Щипелева Ирина Александровна — кандидат биологических наук, ведущий научный сотрудник, учёный секретарь, врио начальника научного отдела

МарковскаяЕ. И.MarkovskayaE. I.

Марковская Елена Ивановна — кандидат медицинских наук, старший научный сотрудник научного от­дела

КретенчукО. Ф.KretenchukO. F.

Кретенчук Оксана Фёдоровна — кандидат биологических наук, старший научный сотрудник научного отдела

ФКУЗ Ростовский-на-Дону научно-исследовательский противочумный институт РоспотребнадзораРоссияRostov-on-Don Antiplague Scientific Research InstituteRussian Federation202007062020653-43944Copyright © Щипелева И.А., Марковская Е.И., Кретенчук О.Ф., 20202020Щипелева И.А., Марковская Е.И., Кретенчук О.Ф.Shchipeleva I.A., Markovskaya E.I., Kretenchuk O.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/721

Обзорная статья включает обобщённые данные литературы об экспериментальной оценке восприимчивости Francisella tularensis к существующим антибиотикам и их эффективности при лечении туляремии человека. Представлены данные о способах повышения эффективности некоторых антибактериальных препаратов, проявляющих сниженную активность при терапии туляремийной инфекции. Обозначен спектр исследований, направленных на создание современных более ре­зультативных антибиотиков, обладающих новыми механизмами действия. Описаны некоторые способы модификации ва­риантов уже известных групп антибактериальных препаратов, а также способы предотвращения или замедления форми­рования антибиотикорезистентности у F.tularensis.

The review article includes summarized literature data on experimental evaluation of Francisella tularensis susceptibility to exist­ing antibiotics, and their effectiveness in treatment of tularemia in humans population. The data on ways to improve the effective­ness of some antibacterial drugs that show reduced activity in treatment of tularemia infection are presented. The range of studies aimed at creating modern and more effective antibiotics with new mechanisms of action is defined. A number of methods for mod­ifying variants of the already known groups of antibacterial drugs, as well as ways of prevention or limitation of antibiotic resist­ance formation in F.tularensis are described.

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The authors declare that there are no conflicts of interest present.