antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2020-65-3-4-45-53antibiotics-722Research ArticleОБЗОРЫREVIEWSСовременное состояние профилактики и лечения лихорадки ЧикунгуньяThe Modern State of Prevention and Treatment of Chikungunya FeverЛогиноваС. Я.LoginovaS. Ja.ЩукинаВ. Н.ShchukinaV. N.БорисевичС. В.BorisevichS. V.48cnii@mil.ruФГБУ «48 Центральный научно-исследовательский институт» Министерства обороны Российской Федерации»Россия48 Central Scientific Research Institute of the Ministry of Defence of the Russian FederationRussian Federation202007062020653-44553Copyright © Логинова С.Я., Щукина В.Н., Борисевич С.В., 20202020Логинова С.Я., Щукина В.Н., Борисевич С.В.Loginova S.J., Shchukina V.N., Borisevich S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/722

Вирус Чикунгунья (CHIKV) — это альфа-вирус, передаваемый людям комарами Aedes, традиционно Aedes aegypti и Aedes albopictus. Вирус вызывает лихорадку Чикунгунья — болезнь, которая характеризуется лихорадкой, тошнотой, головны­ми болями, сыпью и стойкой артралгией. Лихорадка Чикунгунья может быть связана с тяжёлыми осложнениями, вклю­чая смерть. С 2005 г. CHIKV распространяется по всему миру, что приводит к эпидемиям в Африке, островах Индийско­го океана, Азии и совсем недавно в Северной и Южной Америке. Глобально расширяющиеся пандемии с ревматическими расстройствами CHIKV и постинфекционными осложнениями усиливают проблемы общественного здравоохранения. Для лечения этой вирусной инфекции не существует конкретной вакцины или лекарственного средства. Анализ поиска эффек­тивных в отношении CHIKV препаратов показал, что, несмотря на разнообразие направлений исследований, использова­ние современных достижений в молекулярной биологии, нет одобренных и принятых для использования в практической медицине ни этиотропных средств лечения, ни МИБП. Вместе с тем внушают оптимизм новые стратегии в области про­тивовирусных исследований. Комбинированная химиотерапия с интерферонами и противовирусными агентами является привлекательной терапевтической стратегией для обеспечения повышенной противовирусной активности и снижения концентраций препаратов.

The Chikungunya virus (CHIKV) is an alphavirus transmitted to people by Aedes mosquitoes, usually Aedes aegypti and Aedes albopictus. The virus causes Chikungunya fever, a disease characterized by fever, nausea, headaches, rash, and persistent arthral­gia. Chikungunya fever may be associated with severe complications, including death. Since 2005, CHIKV has spread worldwide, leading to epidemics in Africa, Indian Ocean islands, Asia, and, most recently, in the Americas. Globally expanding pandemics with CHIKV rheumatic disorders and post-infectious complications are exacerbating public health problems. There is no specific vac­cine or drug to treat this viral infection. Analysis of the search for effective drugs in relation to CHIKV showed that, despite the diversity of research areas, as well as the use of modern advances in molecular biology, there are no etiotropic treatments or medic­inal immunobiological preparations (MIBPs) approved for use in practical medicine. However, new strategies for antiviral research are encouraging (inspire optimism?). Combined chemotherapy with interferons and antiviral agents is an appealing ther­apeutic strategy for providing increased antiviral activity and reducing drug concentrations.

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The authors declare that there are no conflicts of interest present.