<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">antibiotics</journal-id><journal-title-group><journal-title xml:lang="ru">Антибиотики и Химиотерапия</journal-title><trans-title-group xml:lang="en"><trans-title>Antibiot Khimioter = Antibiotics and Chemotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0235-2990</issn><publisher><publisher-name>ООО «Издательство ОКИ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">antibiotics-724</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕКРОЛОГ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBITUARY</subject></subj-group></article-categories><title-group><article-title>Научный путь члена-корреспондента РАН, профессора А. А. Фирсова</article-title><trans-title-group xml:lang="en"><trans-title>The scientific path of Corresponding Member of the RAS, Professor A. A. Firsop</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Портной</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Portnoy</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голикова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golikova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научно-исследовательский институт по изысканию новых антибиотиков им. Г. Ф. Гаузе</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Gause Institute of New Antibiotics</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>06</month><year>2020</year></pub-date><volume>65</volume><issue>3-4</issue><fpage>55</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Портной Ю.А., Голикова М.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Портной Ю.А., Голикова М.В.</copyright-holder><copyright-holder xml:lang="en">Portnoy Y.A., Golikova M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.antibiotics-chemotherapy.ru/jour/article/view/724">https://www.antibiotics-chemotherapy.ru/jour/article/view/724</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьев В.Н., Фирсов А.А., Филов В.А. Фармакокинетика (руководство). Медицина, М.: 1980.</mixed-citation><mixed-citation xml:lang="en">Соловьев В.Н., Фирсов А.А., Филов В.А. Фармакокинетика (руководство). Медицина, М.: 1980.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Фирсов А.А., Пиотровский В.К. Фармакокинетические методы в биофармации: оценка биодоступности и пресистемная элиминация лекарственных средств. Итоги науки и техники ВИНИТИ, Т. 14, ВИНИТИ, М.: 1984. — С. 113-223.</mixed-citation><mixed-citation xml:lang="en">Фирсов А.А., Пиотровский В.К. Фармакокинетические методы в биофармации: оценка биодоступности и пресистемная элиминация лекарственных средств. Итоги науки и техники ВИНИТИ, Т. 14, ВИНИТИ, М.: 1984. — С. 113-223.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Фирсов А.А., Назаров А. Д., Черных В. М. Фармакокинетические подходы к оптимизации антибиотикотерапии. Итоги науки и техники ВИНИТИ. 1989. — Т. 17.</mixed-citation><mixed-citation xml:lang="en">Фирсов А.А., Назаров А. Д., Черных В. М. Фармакокинетические подходы к оптимизации антибиотикотерапии. Итоги науки и техники ВИНИТИ. 1989. — Т. 17.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Savarino D, Ruble M., Gilbert D., Manzano B., Medeiros A. A., Zinner S. H. Predictors of effect of ampicillin-sulbactam against TEM-1 /3- lactamase-producing Escherichia coli in an in vitro dynamic model: enzyme activity versus MIC. Antimicrob Agents Chemother 1996; 40: 734-738.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Savarino D, Ruble M., Gilbert D., Manzano B., Medeiros A. A., Zinner S. H. Predictors of effect of ampicillin-sulbactam against TEM-1 /3- lactamase-producing Escherichia coli in an in vitro dynamic model: enzyme activity versus MIC. Antimicrob Agents Chemother 1996; 40: 734-738.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Ruble M, Gilbert D., Savarino D., Manzano B., Medeiros A. A., Zinner S. H. Net effect of inoculum size on antimicrobial action of ampi- cillin-sulbactam: studies using an in vitro dynamic model. Antimicrob Agents Chemother 1997; 41: 7-12.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Ruble M, Gilbert D., Savarino D., Manzano B., Medeiros A. A., Zinner S. H. Net effect of inoculum size on antimicrobial action of ampi- cillin-sulbactam: studies using an in vitro dynamic model. Antimicrob Agents Chemother 1997; 41: 7-12.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Mattie. Relationships between antimicrobial effect and area under the concentration-time curve as a basis for comparison of modes of antibiotic administration: meropenem bolus injections versus continuous infusions. Antimicrob Agents Chemother 1997; 41: 352-56.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Mattie. Relationships between antimicrobial effect and area under the concentration-time curve as a basis for comparison of modes of antibiotic administration: meropenem bolus injections versus continuous infusions. Antimicrob Agents Chemother 1997; 41: 352-56.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Shevchenko A. A., Vostrov S. N., Zinner S. H. Inter- and intraquinolone predictors of antimicrobial effect in an in vitro dynamic model: new insight into a widely used concept. Antimicrob Agents Chemother 1998; 42: 659-665.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Shevchenko A. A., Vostrov S. N., Zinner S. H. Inter- and intraquinolone predictors of antimicrobial effect in an in vitro dynamic model: new insight into a widely used concept. Antimicrob Agents Chemother 1998; 42: 659-665.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Vostrov S. N., Shevchenko A. A., Zinner S. H., Cornaglia G., Portnoy Y. A. MIC-based interspecies prediction ofthe antimicrobial effects of ciprofloxacin on bacteria of different susceptibilities in an in vitro dynamic model. Antimicrob Agents Chemother 1998; 42: 2848-2852.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Vostrov S. N., Shevchenko A. A., Zinner S. H., Cornaglia G., Portnoy Y. A. MIC-based interspecies prediction ofthe antimicrobial effects of ciprofloxacin on bacteria of different susceptibilities in an in vitro dynamic model. Antimicrob Agents Chemother 1998; 42: 2848-2852.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Vostrov S. N., Shevchenko A. A., Portnoy Y. A., Zinner S. H. A new approach to in vitro comparisons of antibiotics in dynamic models: equivalent area under the curve /MIC breakpoints and equiefficient doses oftrovafloxacin and ciprofloxacin against bacteria of similar susceptibilities. Antimicrob Agents Chemother 1998; 42: 2841-2847.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Vostrov S. N., Shevchenko A. A., Portnoy Y. A., Zinner S. H. A new approach to in vitro comparisons of antibiotics in dynamic models: equivalent area under the curve /MIC breakpoints and equiefficient doses oftrovafloxacin and ciprofloxacin against bacteria of similar susceptibilities. Antimicrob Agents Chemother 1998; 42: 2841-2847.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Vostrov S. N., Kononenko O. V., Zinner S. H., Portnoy Y. A. Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. Antimicrob Agents Chemother 1999; 43: 498-502.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Vostrov S. N., Kononenko O. V., Zinner S. H., Portnoy Y. A. Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. Antimicrob Agents Chemother 1999; 43: 498-502.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov, A. A., Lubenko I. Y., Portnoy Y. A., Zinner S. H., Vostrov S. N. Relationships of the area under the curve/MIC ratio to different integral endpoints of the antimicrobial effect: Gemifloxacin pharmacodynamics in an in vitro dynamic model. Antimicrob Agents Chemother 2001; 45: 927-931.</mixed-citation><mixed-citation xml:lang="en">Firsov, A. A., Lubenko I. Y., Portnoy Y. A., Zinner S. H., Vostrov S. N. Relationships of the area under the curve/MIC ratio to different integral endpoints of the antimicrobial effect: Gemifloxacin pharmacodynamics in an in vitro dynamic model. Antimicrob Agents Chemother 2001; 45: 927-931.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Zinner S. H. Use of modeling techniques to aid in antibiotic selection. Curr Infect Dis Rep 2001; 3: 35-43.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Zinner S. H. Use of modeling techniques to aid in antibiotic selection. Curr Infect Dis Rep 2001; 3: 35-43.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zinner, S. H., Firsov A. A., Gilbert, D. Simmons K., Lubenko I. Y. The pharmacodynamics of gatifloxacin and ciprofloxacin for pneumococci in an in vitro dynamic model: Prediction of equiefficient doses. J Antimicrob Chemother 2001; 48: 821-826.</mixed-citation><mixed-citation xml:lang="en">Zinner, S. H., Firsov A. A., Gilbert, D. Simmons K., Lubenko I. Y. The pharmacodynamics of gatifloxacin and ciprofloxacin for pneumococci in an in vitro dynamic model: Prediction of equiefficient doses. J Antimicrob Chemother 2001; 48: 821-826.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov, A. A., Vostrov S. N., Lubenko I. Y., Drlica K., Portnoy Y. A., Zinner S. H. In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus. Antimicrob Agents Chemother 2003; 47: 1604-1613.</mixed-citation><mixed-citation xml:lang="en">Firsov, A. A., Vostrov S. N., Lubenko I. Y., Drlica K., Portnoy Y. A., Zinner S. H. In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus. Antimicrob Agents Chemother 2003; 47: 1604-1613.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zinner S. H., Lubenko I. Y., Gilbert D., Simmons K., Zhao X., Drlica K., Firsov A. A. Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing. J Antimicrob Chemother 2003; 52: 616-622.</mixed-citation><mixed-citation xml:lang="en">Zinner S. H., Lubenko I. Y., Gilbert D., Simmons K., Zhao X., Drlica K., Firsov A. A. Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing. J Antimicrob Chemother 2003; 52: 616-622.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Zinner S. H., Lubenko I. Y. In vitro dynamic models as tools to predict antibiotic pharmacodynamics. In: Nightingale C. H., Ambrose P. G., Drusano G. L., Murakawa T.; editors. Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 2nd ed. New York: Informa Healthcare USA, Inc.; 2007; 45-78.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Zinner S. H., Lubenko I. Y. In vitro dynamic models as tools to predict antibiotic pharmacodynamics. In: Nightingale C. H., Ambrose P. G., Drusano G. L., Murakawa T.; editors. Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 2nd ed. New York: Informa Healthcare USA, Inc.; 2007; 45-78.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Firsov A. A., Portnoy Y.A., Zinner S. H. PK/PD-based prediction of «antimutant» antibiotic exposures using in vitro dynamic models. In: Fong I.W., Shlaes D., Drlica K.; Editors. Antimicrobial Resistance in the 21st Century. 2nd ed. Springer International Publishing; 2018; 643-666.</mixed-citation><mixed-citation xml:lang="en">Firsov A. A., Portnoy Y.A., Zinner S. H. PK/PD-based prediction of «antimutant» antibiotic exposures using in vitro dynamic models. In: Fong I.W., Shlaes D., Drlica K.; Editors. Antimicrobial Resistance in the 21st Century. 2nd ed. Springer International Publishing; 2018; 643-666.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Проведение качественных исследований биоэквивалентности лекарственных средств. Методические указания. Под ред. В.Г.Кукеса, В.П.Жердева, А.К.Стародубцева. М.: 2004.</mixed-citation><mixed-citation xml:lang="en">Проведение качественных исследований биоэквивалентности лекарственных средств. Методические указания. Под ред. В.Г.Кукеса, В.П.Жердева, А.К.Стародубцева. М.: 2004.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Фирсов А.А., Жердев В.П., Портной Ю.А., Колыванов Г.Б., Литвин А.А., Барманова Е.Ю. Методические рекомендации по проведению доклинических исследований фармакокинетики лекарственных средств. Под ред. А.Н.Миронова. Руководство по проведению доклинических исследований лекарственных средств. М.: Гриф и К, 2012. — Т. 1. — С. 845-855</mixed-citation><mixed-citation xml:lang="en">Фирсов А.А., Жердев В.П., Портной Ю.А., Колыванов Г.Б., Литвин А.А., Барманова Е.Ю. Методические рекомендации по проведению доклинических исследований фармакокинетики лекарственных средств. Под ред. А.Н.Миронова. Руководство по проведению доклинических исследований лекарственных средств. М.: Гриф и К, 2012. — Т. 1. — С. 845-855</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
