antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-728Research ArticleОБЗОРЫREVIEWSСовременные представления о механизмах резистентности к антимикробным препаратам Enterococcus Faecalis и E. Faecium (обзор литературы)ACTUAL VIEW ON ENTEROCOCCUS FAECALIS AND E. FAECIUM RESISTANCE MECHANISMS TO ANTIBIOTICS (LITERATURE REVIEW)https://orcid.org/0000-0001-5841-0369КоменковаТатьяна СергеевнаKomenkovaTatyana Sergeevna

аспирант Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)

PhD student of the Central Research Laboratory Pacific State Medical University.

atstl@mail.ruhttps://orcid.org/0000-0002-2625-8275ЗайцеваЕлена АлександровнаZaitsevaElena Alexandrovna

д.м.н., доцент, ведущий научный сотрудник Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)

PhD , assistant professor, leading research scientist of the Central Research Laboratory Pacific State Medical University.

elza200707@mail.ruhttps://orcid.org/0000-0002-2625-8275ЗайцеваЕлена АлександровнаZaitsevaElena Alexandrovna

д.м.н., доцент, ведущий научный сотрудник Центральной научно-исследовательской лаборатории ФГБОУ ВО «Тихоокеанский государственный медицинский университет» Минздрава России (г. Владивосток, Россия)

PhD , assistant professor, leading research scientist of the Central Research Laboratory Pacific State Medical University.

elza200707@mail.ruФГБОУ ВО ТГМУ Минздрава РоссииРоссияPacific State Medical University, Vladivostok, RussiaRussian Federation2020160320236511-12728Copyright © Коменкова Т.С., Зайцева Е.А., Зайцева Е.А., 20212021Коменкова Т.С., Зайцева Е.А., Зайцева Е.А.Komenkova T.S., Zaitseva E.A., Zaitseva E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/728

В настоящее время энтерококки все чаще становятся этиологическими агентами разнообразных инфекционных патологий. Наиболее распространенными видами, вызывающими большинство энтерококковых инфекций являются Enterococcus faecalis и E. faecium. Оба вида демонстрируют природную низкоуровневую устойчивость к аминогликозидам, цефалоспоринам, хинолонам, клиндамицину и ко-тримоксазолу. Кроме того, особенности их генома позволяют легко приобретать резистентность к другим, широко используемым в клинической практике антибактериальным препаратам, посредством мутаций или путем горизонтального переноса генетических детерминант устойчивости. В обзоре изложены современные знания о механизмах резистентности энтерококков к наиболее часто используемым антибактериальным препаратам.

Enterococci are currently becoming one of the major causative agents of a various infection diseases. Enterococcus faecalis and E. faecium are the most common species, causing enterococcal infections. Both species exhibit natural low-level resistance to aminoglycosides, cephalosporins, quinolones, clindamycin and co-trimoxazole. In addition, enterococci due to features of their genome can easily acquire resistance genes to widely-used antibiotics through mutations or by horizontal gene transfer. The review represents actual knowledge about the mechanisms of enterococcal resistance to the most commonly used antibiotics.

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The authors declare that there are no conflicts of interest present.