antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-729Research ArticleОБЗОРЫREVIEWSМедицинская палеомикробиология: проблемы и перспективыMedical paleomicrobiology: problems and prospectshttps://orcid.org/0000-0002-5206-6656ГончаровАртемий ЕвгеньевичGoncharovArtemiy E

Гончаров Артемий Евгеньевич – д.м.н., заведующий лабораторией функциональной геномики и протеомики микроорганизмов ФГБНУ Институт экспериментальной медицины, профессор кафедры эпидемиологии, паразитологии и дезинфектологии, ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России, Россия,  доцент кафедры фундаментальных проблем медицины и медицинских технологий ФГБОУ ВО Санкт-Петербургский государственный университет,  Санкт-Петербург, Россия

Artemiy E. Goncharov - Ph.D., Dr. Med. Sci, Head of laboratory of functional genomics and proteomics of microorganisms, Institute of experimental medicine, Russian Federation, 197376, Saint-Petersburg, Academic Pavlov st., 12; Professor at the Department of Epidemiology, Parasitology and Disinfectology of North-Western State Medical University named after I.I. Mechnikov, Russian Federation, 191015, Saint-Petersburg, Kirochnaya str., 41, Saint-Petersburg State University, associate professor at the Department of of fundamental problems of medicine and medical technologies, tel. (812) 303-50-00. E-mail: phage1@yandex.ru

phage1@yandex.ruКолоджиеваВиктория ВасильевнаKolodzhievaViktoria V

Колоджиева Виктория Васильевна – к.м.н., доцент кафедры эпидемиологии, паразитологии и дезинфектологии ФГБОУ ВО «Северо-Западный государственный университет имени И.И. Мечникова» Министерства здравоохранения Российской Федерации, г. Санкт-Петербург, Россия;

Viktoria V. Kolodzhieva - Ph.D., Associate Professor at the Department of Epidemiology, Parasitology and Disinfectology of North- Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russian Federation

vika-el@yandex.ru1. ФГБНУ «Институт экспериментальной медицины» 2. ФГБОУ ВО «Северо-Западный государственные медицинский университет им. И.И. Мечникова» Минздрава РФ 3. ФГБОУ ВО Санкт-Петербургский государственный университетРоссия1.Institute of experimental medicine 2.North-Western State Medical University named after I.I Mechnikov 3. Saint Petersburg State UniversityRussian FederationФГБОУ ВО «Северо-Западный государственные медицинский университет им. И.И. Мечникова» Минздрава РФРоссияNorth-Western State Medical University named after I.I MechnikovRussian Federation202128022023665-6729Copyright © Гончаров А.Е., Колоджиева В.В., 20212021Гончаров А.Е., Колоджиева В.В.Goncharov A.E., Kolodzhieva V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/729

Изучение микробной ДНК из палеонтологических и археологических образцов является мощным инструментом, позволяющим получить исчерпывающую информацию о молекулярной эволюции геномов возбудителей инфекционных заболеваний человека.

Статья представляет собой ретроспективу наиболее значимых достижений медицинской палеомикробиологии. Предметом обсуждения являются результаты исследований по  изучению генетического разнообразия древних микробиомов, содержащих детерминанты патогенности и антибиотикорезистентности. Перспективными представляются палеомикробиологические исследования  многолетней мерзлоты как репозитория патогенной микробиоты.

The study of microbial DNA from paleontological and archaeological samples is a powerful tool for estimating the molecular evolution of human pathogens.

The paper is a retrospective of the most significant achievements in medical paleomicrobiology. The subject of discussion is the genetic diversity of ancient microbiomes including pathogenicity and antibiotic resistance genes. Paleomicrobiological studies of permafrost as a repository of pathogenic microbiota are highly promising.

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The authors declare that there are no conflicts of interest present.