antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2020-65-7-8-42-51antibiotics-753Research ArticleОБЗОРЫREVIEWSПолисахариды морских водорослей - перспективные средства патогенетической терапии инфекционной диареиMarine Algae Polysaccharides - a Promising Means of Pathogenetic Therapy of Infectious DiarrheaБеседноваН. Н.BesednovaN. N.

Беседнова Наталия Николаевна - д. м. н., профессор, академик РАН, главный научный сотрудник лаб. иммунологии

Владивосток

Vladivostok

КузнецоваТ. А.KuznetsovaT. A.

Кузнецова Татьяна Алексеевна - д. м. н., главный научный сотрудник лаб. иммунологии

Сельская, 1, Владивосток, 690087

Vladivostok

takuznets@mail.ruЗапорожецТ. С.ZaporozhetsT. S.

Запорожец Татьяна Станиславовна - д. м. н., главный научный сотрудник лаб. иммунологии

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Vladivostok

КрыжановскийС. П.KryzhanovskyS. P.

Крыжановский Сергей Петрович - д. м. н., проректор по медицинским вопросам

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Vladivostok

ГусеваЛ. Г.GusevаL. G.

Гусева Людмила Григорьевна - главный врач

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Vladivostok

ЗвягинцеваТ. Н.ZvyagintsevaT. N.

Звягинцева Татьяна Николаевна - д. х. н., профессор, главный научный сотрудник лаб. химии ферментов

Владивосток

Vladivostok

Научно-исследовательский институт эпидемиологии и микробиологии им. Г. П. СомоваРоссияSomov Institute of Epidemiology and MicrobiologyRussian FederationМедицинское объединение ДВО РАНРоссияMedical Association of the Far Eastern Branch of the Russian Academy of SciencesRussian FederationТихоокеанский институт биоорганической химии им. Г. Б. Елякова ДВО РАНРоссияG. B. Elyakov Pacific Institute of Bioorganic ChemistryRussian Federation202021112020657-84251Copyright © Беседнова Н.Н., Кузнецова Т.А., Запорожец Т.С., Крыжановский С.П., Гусева Л.Г., Звягинцева Т.Н., 20202020Беседнова Н.Н., Кузнецова Т.А., Запорожец Т.С., Крыжановский С.П., Гусева Л.Г., Звягинцева Т.Н.Besednova N.N., Kuznetsova T.A., Zaporozhets T.S., Kryzhanovsky S.P., Gusevа L.G., Zvyagintseva T.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/753

В обзоре с современных позиций рассмотрены вопросы патогенеза и терапевтические мишени при инфекционной диарее, развивающейся в результате воздействия вирусов или бактериальных токсинов на энтероциты. Охарактеризованы основные методы лечения инфекционной диареи и недостатки стандартной терапии. Представлены современные сведения о биологической активности (бактерицидные/бактериостатические, антивирусные, антибиоплёночные, противовоспалительные, иммуномодулирующие и антиоксидантные свойства) полисахаридов морских водорослей. Оценены возможности использования полисахаридов морских водорослей в качестве основы лекарственных препаратов, БАД к пище и продуктов функционального питания для профилактики и терапии инфекционной диареи.

The review considers the current views on pathogenesis and therapeutic targets in infectious diarrhea that develops as a result of exposure of enterocytes to viruses or bacterial toxins. The main methods of infectious diarrhea treatment and disadvantages of standard therapy are described. Modern data on the biological activity (bactericidal/bacteriostatic, antiviral, anti-biofilm, antiinflammatory, immunomodulatory, and antioxidant properties) of marine algae polysaccharides are presented. The possibilities of using seaweed polysaccharides as the basis of medicines, dietary supplements and functional food products for the prevention and treatment of infectious diarrhea are evaluated.

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The authors declare that there are no conflicts of interest present.