antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2020-65-9-10-37-43antibiotics-764Research ArticleВ ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУGUIDELINES FOR PRACTITIONERSСептическая тромбоэмболия лёгочной артерии у пациентки с генерализованным сальмонеллёзом: клинический случай и метаанализSeptic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-AnalysisСтрутынскаяА. Д.StrutynskayaA. D.

Струтынская Анастасия Дмитриевна — клинический ординатор

Москва 

КарнаушкинаМ. А.KarnaushkinaM. A.

Карнаушкина Мария Александровна — доктор медицинских наук, профессор кафедры госпитальной терапии №2

ул. Трубецкая, 8, стр. 2, ПМГМУ им. И. М. Сеченова, Москва, 119991

ТюринИ. Е.TyurinI. E.

Тюрин Игорь Евгеньевич — доктор медицинских наук, главный внештатный специалист по лучевой и инструментальной диагностике Минздрава России, заведующий кафедрой рентгенологии и радиологии ФГБОУ ДПО «РМАНПО Минздрава России»

Москва

СувороваМ. П.SuvorovaM. P.

Суворова Маргарита Петровна — кандидат медицинских наук, доцент кафедры госпитальной терапии №2

Москва

ЯковлевС. В.YakovlevS. V.

Яковлев Сергей Владимирович — доктор медицинских наук, профессор кафедры госпитальной терапии №2

Москва

Национальный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center for Children-s HealthRussian FederationПервый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian FederationРоссийская Медицинская Академия непрерывного профессионального образованияРоссияRussian Medical Academy of Postgraduate EducationRussian Federation202031122020659-103743Copyright © Струтынская А.Д., Карнаушкина М.А., Тюрин И.Е., Суворова М.П., Яковлев С.В., 20202020Струтынская А.Д., Карнаушкина М.А., Тюрин И.Е., Суворова М.П., Яковлев С.В.Strutynskaya A.D., Karnaushkina M.A., Tyurin I.E., Suvorova M.P., Yakovlev S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/764

Нетифоидные сальмонеллы представляют собой грамотрицательные бактерии, индуцирующие процесс Th1-опосредованного иммунитета. Они редко приводят к развитию септикопиемической формы инфекции, которая преимущественно встречается среди иммунокомпрометированных пациентов с дефектами одного из звеньев клеточно-индуцированного воспаления. Септическая тромбоэмболия лёгочной артерии (ТЭЛА) также является достаточно редким осложнением, при котором эмболы содержат микроорганизмы из первичных внелёгочных очагов. Представленный клинический случай пациентки с ТЭЛА и сальмонеллёзным сепсисом иллюстрирует редкое течение нетифоидного генерализованного сальмонеллёза, обусловленное наличием генетических полиморфизмов Asp299Gly и Thr399Ile в гене TLR4. Данное нарушение функции клеточно-опосредованного иммунитета обусловило развитие деструктивных изменений в лёгочной ткани, повышенное тромбообразование и генерализацию инфекционного процесса.

Nontyphoid Salmonella are gram-negative bacteria that induce Th1-mediated immunity. They rarely lead to a generalized infection, primarily developing in immunocompromised patients with cellular immunity defects. Septic pulmonary embolism is also a rare condition in which emboli contain microorganisms from extrapulmonary infective foci. The article presents a rare clinical case of a patient with pulmonary embolism and generalized nontyphoid salmonellosis due to the presence of Asp299Gly and Thr399Ile genetic polymorphisms in the TLR4 gene. Such a defect of cell-mediated immunity was a trigger for destructive changes in the lung parenchyma, prothrombotic state, and generalization of the infectious process.

сальмонеллезтромбоэмболия лёгочной артериисепсисполиморфизмгенTLR4иммунитетклиническая картинаsalmonellosispulmonary embolismsepsispolymorphismgeneTLR4immunityclinical pictureReferencesAo T.T., Feasey N. A., Gordon M.A., Keddy K. H., Angulo F.J., Crump J.A. Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010. Emer Infect Dis 2015; 21, 6: 941–949. doi:10.3201/eid2106.140999Ao T.T., Feasey N. A., Gordon M.A., Keddy K. H., Angulo F.J., Crump J.A. Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010. Emer Infect Dis 2015; 21, 6: 941–949. doi:10.3201/eid2106.140999Cheng W-L., Li C-W., Li M-C., Lee N-Y., Lee C-C., Ko W-C. Salmonella infective endocarditis. Microbiol Immunol Infect 2016; 49, 3: 313–320. doi: 10.1016/j.jmii.2015.02.659Cheng W-L., Li C-W., Li M-C., Lee N-Y., Lee C-C., Ko W-C. Salmonella infective endocarditis. Microbiol Immunol Infect 2016; 49, 3: 313–320. doi: 10.1016/j.jmii.2015.02.659Crump J. A., Sjölund-Karlsson M., Gordon M. A., Parrye Ch. M. Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. Clin Microbiol Rev 2015; 28, 4: 901–937. doi: 10.1128/CMR.00002-15Crump J. A., Sjölund-Karlsson M., Gordon M. A., Parrye Ch. M. Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. Clin Microbiol Rev 2015; 28, 4: 901–937. doi: 10.1128/CMR.00002-15Eng S-K., Pusparajah P., Mutalib N-S.A., Ser H-L., Chan K-G., Lee L-H. Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance. Frontiers in Life Science. 2015; 8, 3: 1–10. doi:10.1080/21553769.2015.1051243Eng S-K., Pusparajah P., Mutalib N-S.A., Ser H-L., Chan K-G., Lee L-H. Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance. Frontiers in Life Science. 2015; 8, 3: 1–10. doi:10.1080/21553769.2015.1051243Ziakas P. D., Prodromou M. L., Khoury J. El., Zintzaras E., Mylonakis El. The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies. Plos One 2013; 8, 11, e81047. doi: 10.1371/journal.pone.0081047Ziakas P. D., Prodromou M. L., Khoury J. El., Zintzaras E., Mylonakis El. The Role of TLR4 896 A>G and 1196 C>T in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies. Plos One 2013; 8, 11, e81047. doi: 10.1371/journal.pone.0081047Ferwerda B., McCall M.B., Verheijen K., Kullberg B.-J., van der Ven A.J., van der Meer J.W. et al. Functional Consequences of Toll-like Receptor 4 Polymorphisms. Mol Med 2008; 14 (5–6): 346–352. doi:10.2119/2007-00135Ferwerda B., McCall M.B., Verheijen K., Kullberg B.-J., van der Ven A.J., van der Meer J.W. et al. Functional Consequences of Toll-like Receptor 4 Polymorphisms. Mol Med 2008; 14 (5–6): 346–352. doi:10.2119/2007-00135Ye R., Zhao L., Wang C., Wu X., Yan H. Clinical characteristics of septic pulmonary embolism in adults: A systematic review. Respir Med 2014; 108, 1–8. http://dx.doi.org/10.1016/j.rmed.2013.10.012Ye R., Zhao L., Wang C., Wu X., Yan H. Clinical characteristics of septic pulmonary embolism in adults: A systematic review. Respir Med 2014; 108, 1–8. http://dx.doi.org/10.1016/j.rmed.2013.10.012Jiang J., Liang Q.L., Liu L.H., Cai C.Q., Du Z.Q., Kong J.L., Chen Y.Q. Septic pulmonary embolism in China: clinical features and analysis of prognostic factors for mortality in 98 cases. BMC Infect Dis 2019, 19: 1082 https://doi.org/10.1186/s12879-019-4672-1Jiang J., Liang Q.L., Liu L.H., Cai C.Q., Du Z.Q., Kong J.L., Chen Y.Q. Septic pulmonary embolism in China: clinical features and analysis of prognostic factors for mortality in 98 cases. BMC Infect Dis 2019, 19: 1082 https://doi.org/10.1186/s12879-019-4672-1Goswami U., Brenes J. A., Punjabi G.V., LeClaire M.M., Williams D. N. Associations and Outcomes of Septic Pulmonary Embolism. Open Respir Med 2014; 8, 1: 28–33. doi: 10.2174/1874306401408010028Goswami U., Brenes J. A., Punjabi G.V., LeClaire M.M., Williams D. N. Associations and Outcomes of Septic Pulmonary Embolism. Open Respir Med 2014; 8, 1: 28–33. doi: 10.2174/1874306401408010028Song X.Y., Li S., Cao J., Xu K., Huang H., Xu Z.J. Cardiac septic pulmonary embolism а retrospective analysis of 20 cases in a Chinese population. Medicine 2016 95: 25. http://dx.doi.org/10.1097/MD.0000000000003846.Song X.Y., Li S., Cao J., Xu K., Huang H., Xu Z.J. Cardiac septic pulmonary embolism а retrospective analysis of 20 cases in a Chinese population. Medicine 2016 95: 25. http://dx.doi.org/10.1097/MD.0000000000003846.http://www.ensembl.org/Homo_sapiens/Info/Index, дата обращения 02.02.2020http://www.ensembl.org/Homo_sapiens/Info/Index, дата обращения 02.02.2020Konstantinides S.V., Meyer G., Becattini C. ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2019; 1–61.Konstantinides S.V., Meyer G., Becattini C. ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2019; 1–61.Chou D-W., Wu S-L., Chung K-M., Han S-C., Cheung B.M-H. Septic pulmonary embolism requiring critical care: clinicoradiological spectrum, causative pathogens and outcomes causative pathogens and outcomes. Clinics 2016; 71 (10): 562–569. doi: 10.6061/clinics/2016(10)02Chou D-W., Wu S-L., Chung K-M., Han S-C., Cheung B.M-H. Septic pulmonary embolism requiring critical care: clinicoradiological spectrum, causative pathogens and outcomes causative pathogens and outcomes. Clinics 2016; 71 (10): 562–569. doi: 10.6061/clinics/2016(10)02Allegrini D., Reposi S., Nocerino E., Pece A. Odontogenic orbital cellulitis associated with cavernous sinus thrombosis and pulmonary embolism: a case report. Allegrini et al. Med Case Reports 2017, 11: 164. doi: 10.1186/s13256-017-1309-0Allegrini D., Reposi S., Nocerino E., Pece A. Odontogenic orbital cellulitis associated with cavernous sinus thrombosis and pulmonary embolism: a case report. Allegrini et al. Med Case Reports 2017, 11: 164. doi: 10.1186/s13256-017-1309-0Baidya A., Ganakumar V., Jadon R.S., Ranjan P., Manchanda S. R. Sood. Septic pulmonary emboli as a complication of peripheral venous cannula insertion. Drug Discov Ther 2018; 12 (2): 111–113. doi: 10.5582/ddt.2018.01016Baidya A., Ganakumar V., Jadon R.S., Ranjan P., Manchanda S. R. Sood. Septic pulmonary emboli as a complication of peripheral venous cannula insertion. Drug Discov Ther 2018; 12 (2): 111–113. doi: 10.5582/ddt.2018.01016Ben-Chetrit E., Weiner-Well Y., Katz D.E., Rosenman D., Munter G. VSDassociated Right Sided Infective Endocarditis Complicated by Septic Pulmonary Emboli, Am J Med Sci 2016; 352 (1): 107–108. http://dx.doi.org/10.1016/j.amjms.2016.03.007Ben-Chetrit E., Weiner-Well Y., Katz D.E., Rosenman D., Munter G. VSDassociated Right Sided Infective Endocarditis Complicated by Septic Pulmonary Emboli, Am J Med Sci 2016; 352 (1): 107–108. http://dx.doi.org/10.1016/j.amjms.2016.03.007Cheng F-Y., Su Y-J. Septic pulmonary emboli associated with klesiella pneumoniae epididymitis. J Emerg Med 2016; 50 (1): 23–24. http://dx.doi.org/10.1016/j.jemermed.2015.03.044Cheng F-Y., Su Y-J. Septic pulmonary emboli associated with klesiella pneumoniae epididymitis. J Emerg Med 2016; 50 (1): 23–24. http://dx.doi.org/10.1016/j.jemermed.2015.03.044Makrides C., Symeonides M. Gemella morbillorum tricuspid valve endocarditis resulting in septic pulmonary emboli in a patient with intracranial hemorrhage. Intern J Cardiol 2015; 184: 769–771. http://dx.doi.org/10.1016/j.ijcard.2015.02.094Makrides C., Symeonides M. Gemella morbillorum tricuspid valve endocarditis resulting in septic pulmonary emboli in a patient with intracranial hemorrhage. Intern J Cardiol 2015; 184: 769–771. http://dx.doi.org/10.1016/j.ijcard.2015.02.094De Giorgi A., Fabbian F., Molino C., Misurati E., Tiseo R., Parisi C. et al. Pulmonary embolism and internal jugular vein thrombosis as evocative clues of Lemierre-s syndrome: A case report and review of the literature. World J Clin Cases 2017; 5 (3): 112–118 doi: http://dx.doi.org/10.12998/wjcc.v5.i3.112De Giorgi A., Fabbian F., Molino C., Misurati E., Tiseo R., Parisi C. et al. Pulmonary embolism and internal jugular vein thrombosis as evocative clues of Lemierre-s syndrome: A case report and review of the literature. World J Clin Cases 2017; 5 (3): 112–118 doi: http://dx.doi.org/10.12998/wjcc.v5.i3.112De Smet K., Claus P-E., Alliet G., Simpelaere A., Desmet G. Lemierre-s syndrome: a case study with a short review of literature, Acta Clinica Belgica 2018; https://doi.org/10.1080/17843286.2018.1474614De Smet K., Claus P-E., Alliet G., Simpelaere A., Desmet G. Lemierre-s syndrome: a case study with a short review of literature, Acta Clinica Belgica 2018; https://doi.org/10.1080/17843286.2018.1474614Genez M. Septic pulmonary embolism associated with klebsiella spp. infection in a patient with previous ASD operation. Turk J Anaesthesiol Reanim 2019; 47 (6): 511–514. doi: 10.5152/TJAR.2019.39924Genez M. Septic pulmonary embolism associated with klebsiella spp. infection in a patient with previous ASD operation. Turk J Anaesthesiol Reanim 2019; 47 (6): 511–514. doi: 10.5152/TJAR.2019.39924Alonso Ojeda Go´mez J. S., Carrillo Bayona J. A., Morales Cifuentes L. C. Septic pulmonary embolism secondary to Klebsiella pneumoniae epididymitis: case report and literature review. Case Rep Radiol 2019; 53. Article ID 5395090, https://doi.org/10.1155/2019/5395090Alonso Ojeda Go´mez J. S., Carrillo Bayona J. A., Morales Cifuentes L. C. Septic pulmonary embolism secondary to Klebsiella pneumoniae epididymitis: case report and literature review. Case Rep Radiol 2019; 53. Article ID 5395090, https://doi.org/10.1155/2019/5395090Ho V.T., Rothenberg K.A., McFarland G., Tran K., Aalami O.O. Septic pulmonary emboli from peripheral suppurative thrombophlebitis: a case report and literature review. Vascular Endovascular Surg XX(X). doi: 10.1177/1538574418779469Ho V.T., Rothenberg K.A., McFarland G., Tran K., Aalami O.O. Septic pulmonary emboli from peripheral suppurative thrombophlebitis: a case report and literature review. Vascular Endovascular Surg XX(X). doi: 10.1177/1538574418779469Hong G., Kim Y.S. Recurrent septic pulmonary embolism related to an implanted central venous access port device. Chin Med J 2018; 131: 3009–3011. doi: 10.4103/0366-6999.247196Hong G., Kim Y.S. Recurrent septic pulmonary embolism related to an implanted central venous access port device. Chin Med J 2018; 131: 3009–3011. doi: 10.4103/0366-6999.247196Hong J-H., Lu Y-C., Wang S-M. Penile MSSA infection associated dry penile gangrene and pulmonary septic emboli. Am J Med Sci 2017; 353 (3): e5. http://dx.doi.org/10.1016/j.amjms.2016.05.006Hong J-H., Lu Y-C., Wang S-M. Penile MSSA infection associated dry penile gangrene and pulmonary septic emboli. Am J Med Sci 2017; 353 (3): e5. http://dx.doi.org/10.1016/j.amjms.2016.05.006Inchaustegui C. A., Wang K. Y., Teniola O., De Rosen V.L. Large septic pulmonary embolus complicating streptococcus mutans pulmonary valve endocarditis. Radiol Case 2018 Feb; 12 (2): 18–27. doi: 10.3941/jrcr.v12i2.3240Inchaustegui C. A., Wang K. Y., Teniola O., De Rosen V.L. Large septic pulmonary embolus complicating streptococcus mutans pulmonary valve endocarditis. Radiol Case 2018 Feb; 12 (2): 18–27. doi: 10.3941/jrcr.v12i2.3240Jung J.S., Lee S.M., Kim H.J., Jang S-H., Lee J.W. A case of septic pulmonary embolism associated with renal abscess mimicking pulmonary metastases of renal malignancy. Ann Nucl Med 19 November 2013 / Accepted: 13 January 2014. doi: 10.1007/s12149-014-0811-3.Jung J.S., Lee S.M., Kim H.J., Jang S-H., Lee J.W. A case of septic pulmonary embolism associated with renal abscess mimicking pulmonary metastases of renal malignancy. Ann Nucl Med 19 November 2013 / Accepted: 13 January 2014. doi: 10.1007/s12149-014-0811-3.Kashihara E., Fujita K., Koyama H., Mio T. Septic pulmonary embolism complicated by pyogenic spondylitis and psoas abscesses in a patient with methicillin-sensitive Staphylococcus aureus bacteraemia. Oxford Medical Case Reports 2018; 12: 455–457. doi: 10.1093/omcr/omy108.Kashihara E., Fujita K., Koyama H., Mio T. Septic pulmonary embolism complicated by pyogenic spondylitis and psoas abscesses in a patient with methicillin-sensitive Staphylococcus aureus bacteraemia. Oxford Medical Case Reports 2018; 12: 455–457. doi: 10.1093/omcr/omy108.Kitajima S., Kaneko S., Wada T. Septic pulmonary embolism caused by internal shunt infection. Ther Apher Dial 2015; 19 (5): 525–526.Kitajima S., Kaneko S., Wada T. Septic pulmonary embolism caused by internal shunt infection. Ther Apher Dial 2015; 19 (5): 525–526.Lardo S., Ariane A., Chen K. Septic pulmonary embolism following appendectomy surgery. Acta Med Indones. 2015; 47 (3): 234–237.Lardo S., Ariane A., Chen K. Septic pulmonary embolism following appendectomy surgery. Acta Med Indones. 2015; 47 (3): 234–237.Matsumoto K., Yamamoto W., Ohgusa E., Tanaka M., Maruta A., Ishigatsubo Y. et al. Disseminated Cunninghamella bertholletiae infection with septic pulmonary embolism after allogeneic bone marrow transplantation. Transpl Infect Dis 2014; 16: 304–306.Matsumoto K., Yamamoto W., Ohgusa E., Tanaka M., Maruta A., Ishigatsubo Y. et al. Disseminated Cunninghamella bertholletiae infection with septic pulmonary embolism after allogeneic bone marrow transplantation. Transpl Infect Dis 2014; 16: 304–306.Morichika K., Nakachi S., Tomoyose T., Shimabukuro N., Tamaki K., Tedokon I. A rare case of septic pulmonary embolism caused by infectionassociated catheter removal in a patient with hodgkin-s lymphoma. Intern Med 2014; 53: 1215–1220. doi: 10.2169/internalmedicine.53.2092.Morichika K., Nakachi S., Tomoyose T., Shimabukuro N., Tamaki K., Tedokon I. A rare case of septic pulmonary embolism caused by infectionassociated catheter removal in a patient with hodgkin-s lymphoma. Intern Med 2014; 53: 1215–1220. doi: 10.2169/internalmedicine.53.2092.Nii T., Yoshikawa H., Okabe T., Tachibana I. Septic pulmonary and systemic embolism in tricuspid endocarditis. BMJ Case Rep 2014. doi:10.1136/bcr-2014-206569.Nii T., Yoshikawa H., Okabe T., Tachibana I. Septic pulmonary and systemic embolism in tricuspid endocarditis. BMJ Case Rep 2014. doi:10.1136/bcr-2014-206569.Paulis J., Tay E.T. Necrotizing fasciitis with pulmonary septic emboli following an infected insect bite. Yajem 2018. doi:10.1016/j.ajem.2018.08.034Paulis J., Tay E.T. Necrotizing fasciitis with pulmonary septic emboli following an infected insect bite. Yajem 2018. doi:10.1016/j.ajem.2018.08.034Medina-Piñon I., Reyes-Mondragon A. L., Martinez-Resendez M. F., Camacho-Ortiz A. Septic pulmonary emboli and renal abscess caused by staphylococcus aureus in an hiv-infected patient. Case Reports Infect Dis 2018. Article ID 1460283, 3 pages. https://doi.org/10.1155/2018/1460283.Medina-Piñon I., Reyes-Mondragon A. L., Martinez-Resendez M. F., Camacho-Ortiz A. Septic pulmonary emboli and renal abscess caused by staphylococcus aureus in an hiv-infected patient. Case Reports Infect Dis 2018. Article ID 1460283, 3 pages. https://doi.org/10.1155/2018/1460283.Prins W. B., Yilmaz A., Noordzij P. G. Bacterial endocarditis with septic pulmonary embolism due to pacemaker lead infection. Neth Heart J 2014; 22: 127–128. doi: 10.1007/s12471-012-0271-0.Prins W. B., Yilmaz A., Noordzij P. G. Bacterial endocarditis with septic pulmonary embolism due to pacemaker lead infection. Neth Heart J 2014; 22: 127–128. doi: 10.1007/s12471-012-0271-0.Rahhal H., Campos F.P., Ferreira C.R., Felipe-Silva A. Lemierre-s syndrome due to intratumoral abscess of the uvula. Autopsy Case Rep [Internet] 2015; 5 (3): 11–20. http://dx.doi.org/10.4322/acr.2015.015Rahhal H., Campos F.P., Ferreira C.R., Felipe-Silva A. Lemierre-s syndrome due to intratumoral abscess of the uvula. Autopsy Case Rep [Internet] 2015; 5 (3): 11–20. http://dx.doi.org/10.4322/acr.2015.015Reinders S., Bogaard K., Constant L.A., Knol R.J.J. A tortuous road for septic pulmonary emboli in left-sided endocarditis. Can J Cardiol 2014; 30: 1462. e3–e5 www.onlinecjc.ca.Reinders S., Bogaard K., Constant L.A., Knol R.J.J. A tortuous road for septic pulmonary emboli in left-sided endocarditis. Can J Cardiol 2014; 30: 1462. e3–e5 www.onlinecjc.ca.Said S.A.M., Nijhuis R., Derks A., Droste H. Septic pulmonary embolism caused by infected pacemaker leads after replacement of a cardiac resynchronization therapy device. Am J Case Rep 2016; 17: 507–511. doi: 10.12659/AJCR.898009Said S.A.M., Nijhuis R., Derks A., Droste H. Septic pulmonary embolism caused by infected pacemaker leads after replacement of a cardiac resynchronization therapy device. Am J Case Rep 2016; 17: 507–511. doi: 10.12659/AJCR.898009Song X. Y., Li S., Cao J., Xu K., Huang H., Xu Z.J. Cardiac septic pulmonary embolism. A retrospective analysis of 20 cases in a Chinese population. Medicine 2016; 95: 25 (e3846). http://dx.doi.org/10.1097/MD.0000000000003846Song X. Y., Li S., Cao J., Xu K., Huang H., Xu Z.J. Cardiac septic pulmonary embolism. A retrospective analysis of 20 cases in a Chinese population. Medicine 2016; 95: 25 (e3846). http://dx.doi.org/10.1097/MD.0000000000003846Takano Y., Fukuda K., Takayasu H., Shinmura K., Koizumi G., Sasaiet M. et al. Liver abscessation and multiple septic pulmonary emboli associated with Lemierre-s syndrome: a case report. BMC Res Notes 2015; 8: 65. doi: 10.1186/s13104-015-1028-9.Takano Y., Fukuda K., Takayasu H., Shinmura K., Koizumi G., Sasaiet M. et al. Liver abscessation and multiple septic pulmonary emboli associated with Lemierre-s syndrome: a case report. BMC Res Notes 2015; 8: 65. doi: 10.1186/s13104-015-1028-9.Takeda K., Tanaka K., Kumamoto T., Nojiri K., Mori R., Taniguchi K. et al. Septic pulmonary embolism originated from subcutaneous abscess after living donor liver transplantation: a pitfall of postoperative management. Clin J Gastroenterol 2013; 6: 378–382. doi: 10.1007/s12328-013-0400-3/Takeda K., Tanaka K., Kumamoto T., Nojiri K., Mori R., Taniguchi K. et al. Septic pulmonary embolism originated from subcutaneous abscess after living donor liver transplantation: a pitfall of postoperative management. Clin J Gastroenterol 2013; 6: 378–382. doi: 10.1007/s12328-013-0400-3/Uluorman F., Tanriverdi Z., Sevinç C., Badak O., Çatalyürek H. An interesting septic embolism. Respir Med Case Rep 2014; 13: 54–56. http://dx.doi.org/10.1016/j.rmcr.2014.02.001.Uluorman F., Tanriverdi Z., Sevinç C., Badak O., Çatalyürek H. An interesting septic embolism. Respir Med Case Rep 2014; 13: 54–56. http://dx.doi.org/10.1016/j.rmcr.2014.02.001.Veras R. O., Barasuol L.L., de Lira C.P., Klostermann F. C., Müller L. S., Nercolini L. E. Lemierre syndrome: case report. J Vasc Bras 2018, Out. — Dez.; 17 (4): 337–340. https://doi.org/10.1590/1677-5449.002418.Veras R. O., Barasuol L.L., de Lira C.P., Klostermann F. C., Müller L. S., Nercolini L. E. Lemierre syndrome: case report. J Vasc Bras 2018, Out. — Dez.; 17 (4): 337–340. https://doi.org/10.1590/1677-5449.002418.Watanabe T., Yokoe M., Noguchi Y. Septic pulmonary embolism associated with periodontal disease: a case report and literature review. BMC Infect Dis 2019; 19: 74. https://doi.org/10.1186/s12879-019-3710-3.Watanabe T., Yokoe M., Noguchi Y. Septic pulmonary embolism associated with periodontal disease: a case report and literature review. BMC Infect Dis 2019; 19: 74. https://doi.org/10.1186/s12879-019-3710-3.Wu W., Ye S., Chen G.H. Right-sided infective mural endocarditis complicated by septic pulmonary embolism and cardiac tamponade caused by MSSA. Heart Lung 2018. https://doi.org/10.1016/j.hrtlng.2018.05.010.Wu W., Ye S., Chen G.H. Right-sided infective mural endocarditis complicated by septic pulmonary embolism and cardiac tamponade caused by MSSA. Heart Lung 2018. https://doi.org/10.1016/j.hrtlng.2018.05.010.Yao Z., Zheng J., Si Y., Wang W. Pneumocardia and septic pulmonary embolism due to nongas-forming liver abscess. A case report. Medicine 2018; 97: 45 (e13096). http://dx.doi.org/10.1097/MD.0000000000013096Yao Z., Zheng J., Si Y., Wang W. Pneumocardia and septic pulmonary embolism due to nongas-forming liver abscess. A case report. Medicine 2018; 97: 45 (e13096). http://dx.doi.org/10.1097/MD.0000000000013096Bastina M.L.T., Nevilleb N.R., Parsonsb R.E., Flannerya A.H., Tennanta S.J., Johnsonc C.A. An unusual case of Salmonella Enteritidis causing pneumonia, septic shock and multiple organ failure in an immunocompetent patient. IDCases 2016; 6: 85–89. doi: 10.1016/j.idcr.2016.10.004Bastina M.L.T., Nevilleb N.R., Parsonsb R.E., Flannerya A.H., Tennanta S.J., Johnsonc C.A. An unusual case of Salmonella Enteritidis causing pneumonia, septic shock and multiple organ failure in an immunocompetent patient. IDCases 2016; 6: 85–89. doi: 10.1016/j.idcr.2016.10.004Hitchcock J.R., Cook C.N., Bobat S., Ross E.A., Flores-Langarica A., Khan M., Dominguez-Medina C.C., Lax S., Carvalho-Gaspar M. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. Clin Invest 2015; 125 (12): 4429–4446. doi:10.1172/JCI79070Hitchcock J.R., Cook C.N., Bobat S., Ross E.A., Flores-Langarica A., Khan M., Dominguez-Medina C.C., Lax S., Carvalho-Gaspar M. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. Clin Invest 2015; 125 (12): 4429–4446. doi:10.1172/JCI79070MacMahon H., Naidich D.P., Goo V. et al. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017. Radiology 2017; 284 (1): 228–243. doi: 10.1148/radiol.2017161659.MacMahon H., Naidich D.P., Goo V. et al. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017. Radiology 2017; 284 (1): 228–243. doi: 10.1148/radiol.2017161659.

The authors declare that there are no conflicts of interest present.