antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»antibiotics-77Research ArticleОБЗОРЫREVIEWSБактериальные токсин-антитоксиновые системы и новые стратегии создания антибактериальных препаратовBacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial PreparationsАндрюковБ. Г.AndryukovB. G.andrukov_bg@mail.ruБеседноваН. Н.BesednovaN. N.noemail@neicon.ruЗапорожецТ. С.ZaporozhetsT. S.noemail@neicon.ruБынинаМ. П.ByninaM. P.noemail@neicon.ruНИИ эпидемиологии и микробиологии им. Г. П. Сомова; Дальневосточный федеральный университетРоссияG.P. Somov Research Institute of Epidemiology and Microbiology; Far Eastern Federal UniversityRussian FederationНИИ эпидемиологии и микробиологии им. Г. П. СомоваРоссияG.P. Somov Research Institute of Epidemiology and MicrobiologyRussian Federation201806052020633-45058Copyright © ООО «Издательство ОКИ», 20202020ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/77

Интенсивные исследования бактериальных токсин-антитоксиновых систем (ТАС) в последние десятилетия позволили значительно расширить и углубить знания о них. По мере открытия модулей ТАС вначале в плазмидах, а в дальнейшем в хромосомах бактерий, и последующего изучения специфической регуляции активации и функций происходила трансформация отношения к ним как от просто любопытных генетических объектов до одного из важнейших инструментов, играющих решающую роль в бактериальной защите и адаптации к неблагоприятным условиям роста, в том числе, микробной персистенции и хронизации инфекционных процессов, формировании антибиотикорезистентности. Стало понятно, что эти небольшие генетические модули, распространённые почти повсеместно в геномах бактерий, обладают высоким потенциалом для биотехнологических и биомедицинских инновационных исследований, а также перспективны для развития принципиально новых антибактериальных технологий. С учётом ведущей роли TAC в выживании патогенных бактерий и развитии инфекционного процесса, современные технологии создания альтернативных антибактериальных стратегий рассматривают эти системы в качестве перспективных мишеней для разработки новых антимикробных препаратов.

Intensive research of bacterial toxin-antitoxin systems (TAS) in recent decades has significantly expanded and deepened knowldge about them. As TAS modules were first discovered in the plasmids and later in the chromosomes of bacteria, and after subsequent study of their specific regulation of activation and functions, their image has changed from simple curious genetic objects to one of the most important tools. They play a decisive role in bacterial protection and adaptation to unfavorable growth conditions, including microbial persistence and chronic infection processes, formation of antibiotic resistance. It became clear that these small genetic modules, which can be found almost everywhere in the bacterial genomes, have a high potential for biotechnological and biomedical innovation research, as well as the prospect of developing fundamentally new antibacterial technologies. Given the leading role of TAS for the survival of pathogenic bacteria and the development of the infectious process, modern technologies for creating alternative antibacterial strategies consider these systems to be promising targets for the development of new antimicrobial agents.

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The authors declare that there are no conflicts of interest present.