antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2020-65-11-12-38-48antibiotics-775Research ArticleОБЗОРЫREVIEWSСовременные представления о механизмах резистентности к антимикробным препаратам Enterococcus faecalis и Enterococcus faeciumModern View on Enterococcus faecalis and Enterococcus faecium Resistance Mechanisms to Antibioticshttps://orcid.org/0000-0001-5841-0369КоменковаТ. С.KomenkovaT. S.

Коменкова Татьяна Сергеевна — аспирант Центральной научно-исследовательской лаборатории, ResearcherID: Q-1100-2017 eLIBRARY SPIN-код: 1830-1879

пр-т Острякова, 2 пр-т Острякова, 2, г. Владивосток, Приморский край, 690002

elza200707@mail.ruhttps://orcid.org/0000-0002-2625-8275ЗайцеваЕ. А.ZaitsevaE. A.

Зайцева Елена Александровна — д. м. н., доцент, ведущий научный сотрудник Центральной научно-исследовательской лаборатории

Владивосток

ResearcherID: AAE-5268-2019 eLIBRARY SPIN-код: 4617-8685

ФГБОУ ВО «Тихоокеанский государственный медицинский университет» МЗ РФРоссияPacific State Medical UniversityRussian Federation2020130220216511-123848Copyright © ООО «Издательство ОКИ», 20212021ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/775

В настоящее время энтерококки всё чаще становятся этиологическими агентами разнообразных инфекционных патологий. Наиболее распространёнными видами, вызывающими большинство энтерококковых инфекций являются Enterococcus faecalis и E.faecium. Оба вида демонстрируют природную низкоуровневую устойчивость к аминогликозидам, цефалоспоринам, хинолонам, клиндамицину и ко-тримоксазолу. Кроме того, особенности их генома позволяют легко приобретать резистентность к другим, широко используемым в клинической практике антибактериальным препаратам, посредством мутаций или путём горизонтального переноса генетических детерминант устойчивости. В обзоре изложены современные знания о механизмах резистентности энтерококков к наиболее часто используемым антибактериальным препаратам.

Enterococci are currently becoming one of the major causative agents of various infectious diseases. Enterococcus faecalis and E.faecium are the most common species causing enterococcal infections. Both species exhibit natural low-level resistance to aminoglycosides, cephalosporins, quinolones, clindamycin, and co-trimoxazole. In addition, the peculiarities of their genome make it easy to acquire resistance to other antibiotics widely used in clinical practice, through mutations or by horizontal gene transfer. The review represents current knowledge about the mechanisms of enterococcal resistance to the most commonly used antibiotics.

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The authors declare that there are no conflicts of interest present.