antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2021-66-1-2-4-11antibiotics-787Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯEXPERIMENTAL STUDIESКоличественное определение ампициллина тремя независимыми методами с помощью калий гидрогенпероксомоносульфатаComparison of Three Independent Methods of Ampicillin Detection Using Hydrogen PeroxymonosulfateКарповаC. П.KarpovaS. Р.

Карпова С. П. — к. фармац. н., доцент кафедры физической и коллоидной химии

Харьков

Svetlana P. Karpova — Ph. D. in Pharmac

Kharkov

https://orcid.org/0000-0002-8032-347XБлажеевскийН. Е.BlazheyevskiyN. Ye.

Блажеевский Н. Е. — д. х. н., профессор кафедры физической и коллоидной химии

Харьков

Nikolay Ye. Blazheyevskiy — D. Sc. in Chemistry

Kharkov

Национальный фармацевтический университетУкраинаNational University of PharmacyUkraine202105052021661-2411Copyright © Карпова C.П., Блажеевский Н.Е., 20212021Карпова C.П., Блажеевский Н.Е.Karpova S.Р., Blazheyevskiy N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/787

Разработаны три унифицированые методики и показана возможность количественного определения методами кинетико-спектрофотометрии, вольтамперометрии и окислительно-восстановительного титрования ампициллина в субстанции и лекарственном препарате с использованием калий гидрогенпероксомоносульфата (KHSO5) в качестве аналитического реагента. 

Three unified procedures have been developed. The possibility of quantitative determination using the methods of kinetiс spectrophotometry, voltammetry, and redox titration of ampicillin (Amp) as a pure substance and in a drug using potassium hydrogen peroxomonosulfate (KHSO5) as an analytical reagent has been shown.

калий гидрогенпероксомоносульфатампициллинспектрофотометриявольтамперометрияйодометрияhydrogen peroxymonosulfateampicillinspectrophotometryvoltammetryredox titrationReferencesBritish Pharmacopeia. V. 1–6. London: The Stationery Office. 2014; 5860.British Pharmacopeia. V. 1–6. London: The Stationery Office. 2014; 5860.European Pharmacopoeia. 5th Ed. Strasbourg: European Department for the Quality of Medicines. 2005; 2781.European Pharmacopoeia. 5th Ed. Strasbourg: European Department for the Quality of Medicines. 2005; 2781.Фармацевтическая химия. А. П. Арзамасцев (ред.). М.: ЭОТАР. МЕД, 2004; 176.Фармацевтическая химия. А. П. Арзамасцев (ред.). М.: ЭОТАР. МЕД, 2004; 176. [Farmatsevticheskaya khimiya. A. P. Arzamastsev (ed.). Mos cow: EOTAR. MED, 2004; 176. (in Russian)]Liu K., Sun D., Zhao Y. Assay detection for azlocillin sodium and sulbactam sodium for injection by HPLC. Chin J Pharm Anal. 2008; 28: 1568–70.Liu K., Sun D., Zhao Y. Assay detection for azlocillin sodium and sulbactam sodium for injection by HPLC. Chin J Pharm Anal. 2008; 28: 1568–70.Соколова Л.И., Черняев А.П. Определение антибиотиков цефалоспоринового ряда в биологических объектах методом обращено фазовой ВЭЖХ. Хим-фарм журн. 2002; 36: Suppl 5: 39–45.Sokolova L.I., Chernyaev A.P. Opredelenie antibiotikov tsefalosporinovogo ryada v biologicheskikh ob#ektakh metodom obrashcheno-fazovoj VEZhKh. Khim-Farm Zhurn. 2002; 36: Suppl 5: 39–45. (in Russian)Puing P., Borull F., Calull M. Sample stacking for the analysis of eight penicillin antibiotics by micellar electrokinetic capillary chromatography. Electrophor. 2005; 26: 954–961.Puing P., Borull F., Calull M. Sample stacking for the analysis of eight penicillin antibiotics by micellar electrokinetic capillary chromatography. Electrophor. 2005; 26: 954–961.Batrawi N., Wahdan S., Al-Rimawi F. A validated stability-indicating HPLC method for simultaneous determination of amoxicillin and enro floxacin combination in an injectable suspension. Scient Pharm. 2017, 85: Suppl 6: 1–8.Batrawi N., Wahdan S., Al-Rimawi F. A validated stability-indicating HPLC method for simultaneous determination of amoxicillin and enro floxacin combination in an injectable suspension. Scient Pharm. 2017, 85: Suppl 6: 1–8.Государственная фармакопея Украины. Государственное пред приятие «Украинский научный фармакопейный центр качества лекарственных препаратов». 1-е изд. Дополнения 4. Харьков.: РИРЕГ 2011; 367.Gosudarstvennaya farmakopeya Ukrainy. Gosudarst vennoe predpriyatie «Ukrainskij nauchnyj farmakopejnyj tsentr ka chestva lekarstvennykh preparatov». 1-e izd. Dopolneniya 4. Khar'kov.: RIREG 2011; 367. (in Russian)Wang P., Wang B., Cheng X. A method for determination of penicillin G residue in waste penicillin chrysogenum using high performance liquid chromatography. Appl Mech Mat. 2015; 768: 15–24.Wang P., Wang B., Cheng X. A method for determination of penicillin G residue in waste penicillin chrysogenum using high performance liquid chromatography. Appl Mech Mat. 2015; 768: 15–24.Batrawi N., Wahdan S., Al-Rimawi F. A validated stability-indicating HPLC method for simultaneous determination of amoxicillin and enrofloxacin combination in an injectable suspension. Scien Pharm. 2017; 85 (6): 1–8.Batrawi N., Wahdan S., Al-Rimawi F. A validated stability-indicating HPLC method for simultaneous determination of amoxicillin and enrofloxacin combination in an injectable suspension. Scien Pharm. 2017; 85 (6): 1–8.Zhang X., Baeyens W. Chemiluminescence determination of tetracyclines based jn their reaction with hydrogen peroxide catalyzed by the copper ion. Analyst. 1995; 120 (2): 463–466.Zhang X., Baeyens W. Chemiluminescence determination of tetracyclines based jn their reaction with hydrogen peroxide catalyzed by the copper ion. Analyst. 1995; 120 (2): 463–466.Khare B., Khare K. Spectrophotometric determination of antibiotic drug penicillin in pharmaceutical samples using 2,6 dichlorophenol indo phenol, N-bromocaprolactam and N-chlorosuccinimide. Int J Rec Res Phys Chem Sci. 2017; 4: 1–7.Khare B., Khare K. Spectrophotometric determination of antibiotic drug penicillin in pharmaceutical samples using 2,6 dichlorophenol indo phenol, N-bromocaprolactam and N-chlorosuccinimide. Int J Rec Res Phys Chem Sci. 2017; 4: 1–7.Sangeetha S., Kumar M., Kumudhavalli M. Development and validation of UV spectrophotometric area under curve method for quantitative es timation of piperacillin and tazobactam. Int J Chem Tech Res. 2017; 10 (2): 988–994.Sangeetha S., Kumar M., Kumudhavalli M. Development and validation of UV spectrophotometric area under curve method for quantitative es timation of piperacillin and tazobactam. Int J Chem Tech Res. 2017; 10 (2): 988–994.Chaudhary N., Mishra P. Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study. J Saud Chem Soc. 2018; 22 (5): 601–613.Chaudhary N., Mishra P. Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic charac terization, and thermal study. J Saud Chem Soc. 2018; 22 (5): 601–613.Клюев Н.А. Применение масс-спектрометрии и хромато-масс-спектрометрии в анализе лекарственных препаратов. Журн аналит химии. 2002; 57 (6): 566–584.Kljyuev N.A. Primenenie mass-spektrometrii i khromato-mass-spektrometrii v analize lekarstvennykh preparatov. Zhurn Analit Khimii. 2002; 57 (6): 566–584. (in Russian)United States Pharmacopeial Convention. 38th Ed. 2015; 3795.United States Pharmacopeial Convention. 38th Ed. 2015; 3795.Sallach J., Snow D., Hodges L. Development and comparison of four methods for the extraction of antibiotics from a vegetative matrix. Envir Toxicol Chem. 2016; 35 (4): 889–897.Sallach J., Snow D., Hodges L. Development and comparison of four methods for the extraction of antibiotics from a vegetative matrix. Envir Toxicol Chem. 2016; 35 (4): 889–897.Navarro M., Li M., Muller-Bunz H., Bernhard S. Donor-flexible nitrogen ligands for efficient iridium-catalyzed water oxidation catalysis. Eur J Chem. 2016; 22 (20): 6740–6745.Navarro M., Li M., Muller-Bunz H., Bernhard S. Donor-flexible nitrogen ligands for efficient iridium-catalyzed water oxidation catalysis. Eur J Chem. 2016; 22 (20): 6740–6745.Karpova S. P. Quatitative determination of amoxicillin trihydrate in medical forms using kinetic method J Chem Pharm Res. 2014; 6 (4): 1120–1125.Karpova S. P. Quatitative determination of amoxicillin trihydrate in med ical forms using kinetic method J Chem Pharm Res. 2014; 6 (4): 1120–1125.Штыков С.Н., Смирнова Т.Д., Быликин Ю.Г. Флуориметрическое определение тетрациклинов с помощью хелата европия с 1.10-фенантролином в мицеллярных растворах анионных ПАВ. Журн аналит химии. 2005; 60 (1): 30–34.Shtykov S.N., Smirnova T.D., Bylikin Jyu.G. Fluorimetricheskoe opredelenie tetratsiklinov s pomoshch'jyu khelata evropiya s 1.10-fenantrolinom v mitsellyarnykh rastvorakh anionnykh PAV. Zhurn Analit Khimii. 2005; 60 (1): 30–34. (in Russian)Shapiro A. Investigation of β-lactam antibacterial drugs, β-lactamases, and penicillin-binding proteins with fluorescence polarization and an isotropy: a review. Meth Appl Fluor. 2016; 4 (2): 1–8.Shapiro A. Investigation of β-lactam antibacterial drugs, β-lactamases, and penicillin-binding proteins with fluorescence polarization and an isotropy: a review. Meth Appl Fluor. 2016; 4 (2): 1–8.Ahmad A., Rahman N., Islam F. Spectrophotometric determination of ampicillin, amoxycillin, and carbenicillin using folin-ciocalteu phenol reagent. J Anal Chem. 2004; 59 (2): 119–123.Ahmad A., Rahman N., Islam F. Spectrophotometric determination of ampicillin, amoxycillin, and carbenicillin using folin-ciocalteu phenol reagent. J Anal Chem. 2004; 59 (2): 119–123.Dubenska L., Blazhejevskyj M., Plotycya S. Voltammetric methods for the determination of pharmaceuticals. Meth Obj Chem Anal. 2017; 12 (3): 61–75.Dubenska L., Blazhejevskyj M., Plotycya S. Voltammetric methods for the determination of pharmaceuticals. Meth Obj Chem Anal. 2017; 12 (3): 61–75.Belal F., Al-Majed A., Ibrahim K. Voltammetric determination of josamycin (a macrolide antibiotic) in dosage forms and spiked human urine. J Pharm Biomed Anal. 2002; 30 (3): 705–713.Belal F., Al-Majed A., Ibrahim K. Voltammetric determination of josamy cin (a macrolide antibiotic) in dosage forms and spiked human urine. J Pharm Biomed Anal. 2002; 30 (3): 705–713.Кулапина Е.Г., Барагузина В.В., Кулапина О.И. Ионоселективные электроды для определения антибиотиков пенициллинового ряда в биологических жидкостях и лекарственных формах. Журн аналит химии. 2004; 59 (9): 971–975.Kulapina E.G., Baraguzina V.V., Ku lapina O.I. Ionoselektivnye elektrody dlya opredeleniya antibiotikov penitsillinovogo ryada v biologicheskikh zhidkostyakh i lekarstvennyAl-Attas A., El-Enany N., Belal F. A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma. Biomed Chrom. 2015; 29 (12): 1811–1818.Al-Attas A., El-Enany N., Belal F. A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma. Biomed Chrom. 2015; 29 (12): 1811–1818.Bennet D., Yao H., Richardson D. Mechanism of sulfide oxidations by pe roxymonocarbonate. Inorg Chem. 2001; 40 (13)Bennet D., Yao H., Richardson D. Mechanism of sulfide oxidations by peroxymonocarbonate. Inorg Chem. 2001; 40 (13)

The authors declare that there are no conflicts of interest present.