antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2021-66-1-2-57-64antibiotics-794Research ArticleОБЗОРЫREVIEWSРаспространение генов mcr-типа, кодирующих устойчивость к полимиксинам, в России и миреDissemination of MCR-Type Genes Encoding Polymyxin Resistance in Russia and Across the GlobeАгеевецВ. А.AgeevetsV. A.

Агеевец Владимир Андреевич — к. б. н.Санкт-Петербург

 

Vladimir A. Ageevets — Ph. D. in Biology

Saint Petersburg

ЛазареваИ. В.SulyanО. S.

Лазарева Ирина Владимировна — к. м. н.

Санкт-Петербург

Ophelia S. Sulyan

Saint Petersburg

СулянО. С.LazarevaI. V.

Сулян Офелия Спартаковна

Санкт-Петербург

Irina V. Lazareva — Ph.D. in Medicine

Saint Petersburg

СухининА. А.SukhininA. A.

Сухинин Александр Александрович

Санкт-Петербург

Alexander A. Sukhinin

Saint Petersburg

Детский научно-клинический центр инфекционных болезнейРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian FederationДетский научно-клинический центр инфекционных болезней; Санкт-Петербургский государственный университет ветеринарной медициныРоссияPediatric Research and Clinical Center for Infectious Diseases; Saint Petersburg State Academy of Veterinary MedicineRussian FederationСанкт-Петербургский государственный университет ветеринарной медициныРоссияSaint Petersburg State Academy of Veterinary MedicineRussian Federation202106052021661-25764Copyright © ООО «Издательство ОКИ», 20212021ООО «Издательство ОКИ»ООО «Издательство ОКИ»https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNoticehttps://www.antibiotics-chemotherapy.ru/jour/article/view/794

В 2015 году впервые был описан ген устойчивости к полимиксинам mcr-типа, локализованный на мобильном генетическом элементе. После первого описания, последовали публикации, демонстрирующие глобальное распространение генов mcr-типа и роль животноводства в этом процессе. Одновременно, на фоне распространения генов приобретённой резистентности к карбапенемным антибиотикам, растёт практическое значение  полимиксинов. Данный обзор кратко суммирует принципиальные данные, посвящённые данной проблеме.

The MCR-type polymyxin resistance gene localized on a mobile genetic element was described was described in 2015 for the first time. Publications, following the first description, demonstrated the global distribution of MCR-type genes and the role of animal husbandry in this process. At the same time, practical importance of polymyxins is growing, considering spread of genes of acquired resistance to carbapenem antibiotics. This review briefly summarizes the principal data on this issue. 

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The authors declare that there are no conflicts of interest present.