antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2021-66-1-2-65-74antibiotics-795Research ArticleОБЗОРЫREVIEWSПерспектива сукцинатов в условиях гипоксии при Сovid-19The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19ОрловЮ. П.OrlovYu. Р.

Орлов Юрий Петрович — д. м. н., профессор кафедры анестезиологии и реаниматологии

Омск

Yury P. Orlov — D. Sc. in Medicine

Omsk

АфанасьевВ. В.AfanasyevV. V.

Афанасьев Василий Владимирович — д. м. н., профессор кафедры неотложной медицины

Санкт-Петербург

Vasily V. Afanasyev — D. Sc. in Medicine

Saint Petersburg

 

ХиленкоИ. А.KhilenkoI. A.

Хиленко Ирина Анатольевна — заведующая отделением анестезиологии и реаниматологии  

Омск

Irina A. Khilenko — Head of the intensive care unit

Омский государственный медицинский университетРоссияOmsk State Medical UniversityRussian FederationСеверо-Запаный государственный медицинский университет им. И. И. МечниковаРоссияNorth-Western State Medical University named after I. I. MechnikovRussian FederationБУЗОО «Городская клиническая больница №11»РоссияCity Clinical Hospital No. 11, OmskRussian Federation202106052021661-26574Copyright © Орлов Ю.П., Афанасьев В.В., Хиленко И.А., 20212021Орлов Ю.П., Афанасьев В.В., Хиленко И.А.Orlov Y.Р., Afanasyev V.V., Khilenko I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/795Цель

Цель. Поиск материалов экспериментальных и клинических исследований, отражающих патогенетическую роль возможного использования сукцинатов в коррекции гипоксии при COVID-19. Материалы и методы. Проанализировано 79 зарубежных и отечественных литературных источников, касающихся патогенеза COVID-19 и патогенетической роли сукцинатов при гипоксии в условиях COVID-19, окислительного стресса и диафрагмальной дисфункции. Поиск литературы проводился по базам данным Pubmed, ELIBRARY.ru. 

Результаты

Результаты. Как показал анализ литературы в основе патогенеза COVID-19 лежит гипоксия тканей, запускающая весь каскад патоморфологических событий, приводящих к развитию полиорганной недостаточности. В ряде экспериментальных и клинических исследований (на достаточно большом числе пациентов) отражён положительный эффект коррекции гипоксии тканей с использованием сукцинатов как у взрослых пациентов, так и у детей при различном спектре патологии, сопряжённой с синдромом острой дыхательной недостаточности. 

Заключение

Заключение. Анализ литературных данных позволяет обосновать перспективу использования препаратов, содержащих сукцинат (реамберин, цитофлавин), в комплексной терапии тяжёлых случаев течения COVID-19.

The aim of the work was the search for materials from experimental and clinical studies reflecting the pathogenetic role of the possible use of succinates for the correction of hypoxia in COVID-19. 

Materials and methods

Materials and methods. 79 foreign and domestic literature sources were analyzed concerning the pathogenesis of COVID-19 and the pathogenetic role of succinates in hypoxia under conditions of COVID-19, oxidative stress, and diaphragmatic dysfunction were analyzed. The literature search was carried out using Pubmed and ELIBRARY.ru databases. 

Results

Results. As the analysis of the literature has shown, tissue hypoxia is the basis of COVID-19 pathogenesis, triggering the entire cascade of  pathomorphological events leading to the development of multiple organ failure. A number of experimental and clinical studies (on a fairly large number of patients) reflect the positive effect of tissue hypoxia correction using succinates, both in adult patients and in children with a different spectrum of pathology associated with acute respiratory failure syndrome. 

Conclusion

Conclusion. Analysis of literature data allows to substantiate the prospect of using preparations containing succinate (reamberin, cytoflavin) in the complex therapy of severe cases of COVID-19. 

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The authors declare that there are no conflicts of interest present.