References

antibiotics

Антибиотики и Химиотерапия

Antibiot Khimioter = Antibiotics and Chemotherapy

0235-2990

ООО «Издательство ОКИ»

10.37489/0235-2990-2021-66-3-4-62-81

antibiotics-806

Research Article

ОБЗОРЫ

REVIEWS

Полифенолы из наземных и морских растений как ингибиторы репродукции коронавирусов

Polyphenols Sourced from Terrestrial and Marine Plants as Coronavirus Reproduction Inhibitors

https://orcid.org/0000-0002-2760-9778

Беседнова

Н. Н.

Besednova

N. N.

Беседнова Наталия Николаевна — д. м. н., профессор, академик РАН, главный научный сотрудник лаб. иммунологии

eLIBRARY SPIN-код: 8931-9002. Scopus Author ID: 7006805123

ул. Сельская, 1, г. Владивосток, 690087

Natalia N. Besednova — D. Sc. in medicine, Professor, Academician of the Russian Academy of Sciences

eLIBRARY SPIN: 8931-9002. Scopus Author ID: 7006805123

1 Selskaya str., Vladivostok, 690087

https://orcid.org/0000-0003-4456-808X

Андрюков

Б. Г.

Andryukov

B. G.

Андрюков Борис Георгиевич — д. м. н., ведущий научный сотрудник лаборатории молекулярной микробиологии

ResearcherID: J-3752-2018. eLIBRARY SPIN-код: 7757-3838. Scopus Author ID: 57191370698

Владивосток

Boris G. Andryukov — D.Sc. in medicine

ResearcherID: J-3752-2018. eLIBRARY SPIN: 7757-3838. Scopus Author ID: 57191370698

Vladivostok

https://orcid.org/0000-0002-2760-9778

Запорожец

Т. С.

Zaporozhets

T. S.

Запорожец Татьяна Станиславовна — д. м. н., главный научный сотрудник лаборатории иммунологии

ResearcherID: Y-9425-2018. eLIBRARY SPIN-код: 8931-9002. Scopus Author ID: 7006805123

Владивосток

Tatyana S. Zaporozhets — D.Sc. in medicine

ResearcherID: Y-9425-2018. eLIBRARY SPIN: 8931-9002. Scopus Author ID: 7006805123

Vladivostok

https://orcid.org/0000-0002-4315-6959

Кузнецова

Т. А.

Kuznetsova

T. A.

Кузнецова Татьяна Алексеевна — д. м. н., главный научный сотрудник лаборатории иммунологии

ResearcherID: I-8399-2018. eLIBRARY SPIN-код: 2359-1132. Scopus Author ID: 7202571979

Владивосток

Tatyana A. Kuznetsova — D.Sc. in medicine

ResearcherID: I-8399-2018. eLIBRARY SPIN code: 2359-1132. Scopus Author ID: 7202571979

Vladivostok

Крыжановский

С. П.

Kryzhanovskiy

S. P.

Крыжановский Сергей Петрович — д. м. н., ученый секретарь

Владивосток

Sergey P. Kryzhanovsky — D.Sc. in medicine

Vladivostok

https://orcid.org/0000-0002-9849-8358

Федянина

Л. Н.

Fedyanina

L. N.

Федянина Людмила Николаевна — д. м. н., профессор Департамента Фундаментальной медицины Школы биомедицины

ResearcherID: AAG-4121-2019. eLIBRARY SPIN-код: 9803-6837. Scopus Author ID: 24481010600

Владивосток

Lyudmila N. Fedyanina — D.Sc. in medicine

ResearcherID: AAG-4121-2019. eLIBRARY SPIN: 9803-6837. Scopus Author ID: 24481010600

Vladivostok

https://orcid.org/0000-0001-6450-840X

Макаренкова

И. Д.

Makarenkova

I. D.

Макаренкова Илона Дамировна — д. м. н., ведущий научный сотрудник лаборатории иммунологии

ResearcherID: B-6799-2018. eLIBRARY SPIN-код: 3213-4380. Scopus Author ID: 6507363521

Владивосток

Ilona D. Makarenkova — D.Sc. in medicine

ResearcherID: B-6799-2018. eLIBRARY SPIN: 3213-4380. Scopus Author ID: 6507363521

Vladivostok

https://orcid.org/0000-0001-7000-5833

Галкина

И. В.

Galkina

I. V.

Галкина Ирина Вячеславовна — к. м. н., ведущий научный сотрудник Школы биомедицины

eLIBRARY SPIN-код: 7224-0756. Sopus Author ID: 7003393038

Владивосток

Irina V. Galkina — Ph.D. in medicine

eLIBRARY SPIN: 7224-0756. Sopus Author ID: 7003393038

Vladivostok

https://orcid.org/0000-0001-8610-7623

Щелканов

М. Ю.

Shchelkanov

M. Yu.

Щелканов Михаил Юрьевич — д. б. н., директор; зав.кафедрой эпидемиологии, микробиологии и паразитологии с Международным научно-образовательным Центром биологической безопасности Школы биомедицины; зав. лабораторией вирусологии

ResearcherID: L-6164-2016. eLIBRARY SPIN-код: 5736-7230. Scopus Author ID: 7004251692

Владивосток

Mikhail Yu. Shchelkanov — D.Sc. in medicine

ResearcherID: L-6164-2016. eLIBRARY SPIN: 5736-7230. Scopus Author ID: 7004251692

Vladivostok

НИИ эпидемиологии и микробиологии им. Г. П. СомоваРоссияScientific Research Institute of Epidemiology and Microbiology named after G. P. SomovRussian Federation

НИИ эпидемиологии и микробиологии им. Г. П. Сомова; Дальневосточный филиал НИИ военной медициныРоссияScientific Research Institute of Epidemiology and Microbiology named after G. P. Somov; Far Eastern Branch of the Research Institute of the Ministry of Defence of the Russian FederationRussian Federation

Медицинское объединение ДВО РАНРоссияMedical Association of the Far Eastern Branch of the Russian Academy of SciencesRussian Federation

Дальневосточный федеральный университетРоссияFar Eastern Federal UniversityRussian Federation

Дальневосточный федеральный университетРоссияMedical Association of the Far Eastern Branch of the Russian Academy of SciencesRussian Federation

НИИ эпидемиологии и микробиологии им. Г. П. Сомова; Дальневосточный федеральный университет; ФНЦ биоразнообразия наземной биоты Восточной Азии ДВО РАН; Национальный научный центр морской биологии им. А. В. Жирмунского ДВО РАНРоссияScientific Research Institute of Epidemiology and Microbiology named after G. P. Somov; Medical Association of the Far Eastern Branch of the Russian Academy of Sciences; Federal Scientific Center of the East Asia Terrestrial Biodiversity of the Far Eastern Branch of the Russian Academy of Sciences; A. V. Zhirmunsky National Scientific Center of Marine Biology of the Far Eastern Branch of the Russian Academy of SciencesRussian Federation

2021

25062021

663-46281

2021

ООО «Издательство ОКИ»

https://www.antibiotics-chemotherapy.ru/jour/about/submissions#copyrightNotice

https://www.antibiotics-chemotherapy.ru/jour/article/view/806

В настоящем обзоре представлены материалы последних лет, касающиеся важнейшей проблемы современности — поиску новых ингибиторов репродукции коронавирусов. В качестве перспективных соединений такого плана рассматриваются полифенольные соединения из наземных и морских растений, поливалентные биорегуляторы, обладающие множественной биологической активностью. Полифенолы способны вмешиваться в разные этапы жизненного цикла вирусов, что характеризует их как многоцелевые препараты, действующие на жизненно важные белки возбудителя. Вместе с тем, авторы обзора обращают внимание на то, что для разработки лекарственных препаратов на основе растительных полифенолов необходимо преодолеть достаточно много трудностей, поскольку эти соединения характеризуются сложностью структур, низкой биодоступностью и быстрым выведением из организма. Кроме того, требуется проведение глубоких исследований in vivo на животных, а также в клинических условиях. Несмотря на все трудности, растительные полифенолы со временем должны найти свое место в качестве кандидатов для создания на их основе противовирусных лекарственных средств, биологически активных добавок к пище и продуктов функционального питания.

The review presents the data of recent years concerning the most important modern problem — the search of the new inhibitors of coronaviruses’ reproduction. Polyphenolic compounds (phlorotannins) from terrestrial and marine plants, polyvalent bioregulators with multiple biological activity, are considered as promising compounds of this type. Polyphenols are able to interfere with different stages of coronaviruses’ life cycle. This fact characterizes polyphenols as multipurpose drugs that affect vital proteins of the pathogens. At the same time, the authors of the review draw attention to the fact that many difficulties must be overcome to develop medications based on plant polyphenols, since these compounds are characterized by complex structures, low bioavailability, as well as rapid excretion from the body. In addition, in vivo studies on animals, as well as in clinical trials, are required. Despite all the difficulties, plant polyphenols should eventually the source for creating antiviral medicines, biologically active food additives, and functional food products.

полифенолы наземных и морских растенийфлоротанниныингибиторы репродукции коронавирусов

polyphenols of terrestrial and marine plantsphlorotanninsnatural compoundsinhibitors of coronavirus reproduction

Работа выполнена при поддержке гранта РФФИ 20-04-6021.

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The authors declare that there are no conflicts of interest present.