antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2021-66-5-6-78-85antibiotics-823Research ArticleОБЗОРЫREVIEWSБета-лактамные антибиотики — препараты резерва для лечения лекарственно-резистентного туберкулёзаBeta-lactam antibiotics as reserve medications for the treatment of drug-resistant tuberculosisМожокинаГ. Н.MozhokinaG. N.

Можокина Галина Николаевна — д. м. н., ведущий научный сотрудник лаборатории иммунологии и иммунодиагностики туберкулёзной инфекции

Москва

Galina N. Mozhokina — D. Sc. in medicine

Moscow

mojokina@mail.ruСамойловаА. Г.SamoilovaA. G.

Самойлова Анастасия Геннадьевна — д. м. н., первый заместитель директора

Москва

Anastasia G. Samoilova — D. Sc. in medicine

Moscow

ВасильеваИ. А.VasilyevaI. A.

Васильева Ирина Анатольевна — д. м. н., профессор, директор

Москва

Irina A. Vasilyeva — D. Sc. in medicine

Moscow

ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian Federation202130082021665-67885Copyright © Можокина Г.Н., Самойлова А.Г., Васильева И.А., 20212021Можокина Г.Н., Самойлова А.Г., Васильева И.А.Mozhokina G.N., Samoilova A.G., Vasilyeva I.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/823

В обзорной статье представлен анализ данных литературы о необходимости расширения спектра препаратов с противотуберкулёзной активностью для лечения наиболее тяжёлых форм лекарственно-устойчивого туберкулёза за счёт применения бета-лактамов в схемах химиотерапии. Показан механизм действия бета-лактамов на микобактерии туберкулёза и представлены результаты исследований in vitro по оценке их противотуберкулёзной активности. Клинические исследования по применению карбапенемов доказывают перспективность их использования для лечения больных туберкулёзом с множественной и широкой лекарственной устойчивостью возбудителя.

The review article presents an analysis of literature data on the necessity to expand the range of medications possessing anti-tuberculosis activity for the treatment of the most severe forms of drug-resistant tuberculosis through the use of beta-lactam antibiotics in chemotherapy regimens. The mechanism of action of beta- lactam antibiotics on mycobacterium tuberculosis is shown, and the results of in vitro studies to assess their anti-tuberculosis activity are presented. Clinical studies on the use of carbapenems prove the feasibility of their use for the treatment of patients with tuberculosis with multiple and extensive drug resistance of the pathogen.

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The authors declare that there are no conflicts of interest present.