antibioticsАнтибиотики и ХимиотерапияAntibiot Khimioter = Antibiotics and Chemotherapy0235-2990ООО «Издательство ОКИ»10.37489/0235-2990-2021-66-7-8-100-108antibiotics-844Research ArticleОБЗОРЫREVIEWSПатогенетическая роль и возможности коррекции нарушения кишечной микробиоты при инфекции мочевых путейPathogenetic Role and Possibilities for Correction of Gut Microbiota Disorders in Urinary Tract Infectionshttps://orcid.org/0000-0002-3138-8410СтуровН. В.SturovN. V.

Стуров Николай Владимирович — к. м. н., доцент, заведующий кафедрой общей врачебной практики, заместитель директора по учебной работе Медицинского института

Москва

Nikolay V. Sturov — Ph. D. in medicine, Associate Professor

Moscow

https://orcid.org/0000-0002-0567-4616ПоповС. В.PopovS. V.

Попов Сергей Витальевич — д. м. н., профессор кафедры общей врачебной практики Медицинского института, врач-уролог,

ул. Миклухо-Маклая, 6, г. Москва, 117198

Sergey V. Popov — D. Sc. in medicine

32 11th Parkovaya Street, Moscow, 105077

servit77@yandex.ruhttps://orcid.org/0000-0001-9995-264XЖуковВ. А.ZhukovV. A.

Жуков Владимир Андреевич — аспирант кафедры общей врачебной практики Медицинского института

Москва

Vladimir A. Zhukov — post-graduate student of the Department of General Medical Practice

Moscow

ФГАОУ ВО «Российский университет дружбы народов» Минобрнауки РоссииРоссияRUDN UniversityRussian Federation202121102021667-8100108Copyright © Стуров Н.В., Попов С.В., Жуков В.А., 20212021Стуров Н.В., Попов С.В., Жуков В.А.Sturov N.V., Popov S.V., Zhukov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.antibiotics-chemotherapy.ru/jour/article/view/844

В статье представлены современные данные о роли кишечной микробиоты в развитии инфекций мочевых путей. Показаны основные патогенетические механизмы, способствующие хроническому рецидивирующему течению заболевания, распространению устойчивости к антимикробным препаратам и их связь с нарушениями кишечной микробиоты. Известно, что большинство возбудителей мочевых инфекций происходят из кишечной микробиоты, где они длительно существуют, формируя резервуары. Нормальный состав и функции микробиоты препятствуют колонизации кишечника патогенными бактериями и снижают риск развития данного заболевания. Рассматриваются пути коррекции посредством диеты, пробиотиков и трансплантации фекальной микробиоты. Модуляция кишечной микробиоты может стать перспективным подходом в терапии и профилактике инфекций мочевых путей. Между тем, качественная доказательная база по эффективности рассматриваемой стратегии не сформирована. Требуются дальнейшие исследования в данном направлении.

The article presents current data on the role of gut microbiota in the development of urinary tract infections. The main pathogenetic mechanisms contributing to the chronic recurrent course of the disease, the spread of antimicrobial resistance, as well as their connection to the disorders of gut microbiota are shown. It is known that most pathogens of urinary infections originate from the gut microbiota, where they exist for a long time, forming reservoirs. The normal composition and functions of the microbiota prevent colonization of the intestine by pathogenic bacteria and reduce the risk of developing this disease. Ways of correction through diet, probiotics, as well as fecal microbiota transplantation are considered. Modulation of gut microbiota may be a promising approach in the treatment and prevention of urinary tract infections. Meanwhile, a qualitative evidence base on the effectiveness of this strategy has not been formed. Further research in this direction is required.

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The authors declare that there are no conflicts of interest present.